7295718
Questão 1
Questão
Bactericidal drugs kill bacteria.
Responda
- True
- False
Questão 2
Questão
Which class of drugs slows bacterial growth?
Responda
-
Bactericidal
-
Bacteriostatic
Questão 3
Questão
When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Responda
-
Increase
-
Decrease
-
Stay the same
Questão 4
Questão
When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Responda
-
Increase
-
Decrease
-
Stay the same
Questão 5
Questão
When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Responda
-
Increase
-
Decrease
-
Stay the same
Questão 6
Questão
When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Responda
-
Increase
-
Decrease
-
Stay the same
Questão 7
Questão
Are the actions of sulphonamides bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 8
Questão
Is the action of trimethaprim bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 9
Questão
Are the actions of tetracyclines bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 10
Questão
Is the action of chloramphenicol bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 11
Questão
Is the action of linomycin bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 12
Questão
Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 13
Questão
Are the actions of penicillins bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 14
Questão
Are the actions of cephalosporins bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 15
Questão
Are the actions of fluoroquinolones bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 16
Questão
Are the actions of aminoglycosides bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 17
Questão
Is the action of metronidazole bactericidal or bacteriostatic?
Responda
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Questão 18
Questão
A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?
Responda
-
Sulphonamide and Erythromycin
-
Sulphonamide and Fluoroquinolone
-
Sulphonamide and Trimethoprim
-
Sulphonamide and Chloramphenicol
-
Sulphonamide and Cephalosporin
Questão 19
Questão
What is the main aim for optimum efficacy of a time dependent drug?
Responda
-
Plasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period
-
Plasma levels should be as high as possible for as long as possible
-
The dosage is irrelevant, but the drug must be in the system for as long as possible
Questão 20
Questão
Which of the following drugs is time dependent?
Responda
-
Aminoglycoside
-
Penicillin
-
Fluoroquinolones
-
Metronidazole
Questão 21
Questão
Which of the following drugs is time dependent?
Responda
-
Aminoglycoside
-
Cephalosporin
-
Fluoroquinolone
-
Metronidazole
Questão 22
Questão
Which of the following drugs are concentration dependent?
Responda
-
Penicillin
-
Aminoglycoside
-
Metronidasole
-
Cephalosporin
-
Fluoroquinolone
Questão 23
Questão
Where are NAMA and NAG synthesised?
Responda
-
Cytoplasm
-
Membrane
-
Extra-membrane
Questão 24
Questão
How many peptides are initially attached to NAMA?
Responda
-
3
-
4
-
5
-
6
Questão 25
Questão
What is the most important feature for the activity of a penicillin/cephalosporin?
Responda
-
Ring of 2 carbons and 2 nitrogens
-
Ring of 3 carbons and 1 nitrogen
-
Ring of 5 carbons
-
Ring of 5 carbons and 1 nitrogen
-
Ring of 4 carbons and 2 nitrogens
Questão 26
Questão
What determines the antibacterial activity of β-lactams?
Responda
-
R side chain
-
Ability to bind to peptidyl transferase
-
Ability to bind to transpeptidases
-
Drug size
-
Ability to bind to gamma-glutamyl transpeptidase
Questão 27
Questão
The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.
Responda
- True
- False
Questão 28
Questão
Clavulanic acid has an antibacterial effect when administered alone.
Responda
- True
- False
Questão 29
Questão
Which of the following drugs would be best paired with clavulanic acid?
Responda
-
Mecillinam
-
Cloxacillin
-
Benzylpenicillin
-
Methicillin
-
Amoxicillin
Questão 30
Questão
Benzylpenicillin has good acid stability.
Responda
- True
- False
Questão 31
Questão
Which of the following drugs are susceptible to β-lactamase activity?
Responda
-
Benzylpenicillin
-
Penicillin V
-
Cloxacillin
-
Methicillin
-
Ampicillin
-
Amoxicillin
-
Carbenicillin
-
Mecillinam
Questão 32
Questão
Which of the following drugs are not susceptible to β-lactamase activity?
Responda
-
Cloxacillin
-
Benzylpenicillin
-
Methicillin
-
Mecillinam
-
Carbenicillin
Questão 33
Questão
Which of the following drugs are most effective against Gram +ve cocci?
Responda
-
Benzylpenicillin
-
Mecillinam
-
Penicillin V
-
Cloxacillin
-
Methicillin
Questão 34
Questão
Which of the following drugs is most active against Gram -ve bacteria?
Responda
-
Mecillinam
-
Methicillin
-
Cloxacillin
-
Carbenicillin
Questão 35
Questão
Which of the following drugs is efficacious against pseudomonas?
Responda
-
Mecillinam
-
Cloxacillin
-
Carbenicillin
-
Methicillin
Questão 36
Questão
Which generations of cephalosporins are unstable in acid?
Responda
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Questão 37
Questão
Which generation of cephalosporin has the least β-lactamase stability?
Responda
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Questão 38
Questão
Which generations of cephalosporin are least susceptible to β-lactamase activity?
Responda
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Questão 39
Questão
Which of the following drugs is most efficacious against gram +ve bacteria?
Responda
-
Cephalexin
-
Cefuroxime
-
Cefovecin
-
Cefquinome
Questão 40
Questão
Which of the following drugs is most efficacious against gram -ve bacteria?
Responda
-
Cephradine
-
Cephalexin
-
Cefquinome
-
Cefovecin
Questão 41
Questão
Which of the following drugs is efficacious against pseudomonas?
Responda
-
Cephradine
-
Cefovecin
-
Cefquinome
-
Cefuroxime
Questão 42
Questão
Penicillins and cephalosporins are eliminated by the liver.
Responda
- True
- False
Questão 43
Questão
Penicillins do not cross the BBB, despite being widely distributed.
Responda
- True
- False
Questão 44
Questão
Some cephalosporins cross the BBB.
Responda
- True
- False
Questão 45
Questão
Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.
Responda
- True
- False
Questão 46
Questão
What type of bacteria are aminoglycosides more efficacious against?
Responda
-
Gram -ve anaerobic bacteria
-
Gram -ve aerobic bacteria
-
Gram +ve anaerobic bacteria
-
Gram +ve aerobic bacteria
Questão 47
Questão
Aminoglycosides are typically bactericidal.
Responda
- True
- False
Questão 48
Questão
Aminoglycosides have poor oral bioavailability.
Responda
- True
- False
Questão 49
Questão
How are aminoglycosides eliminated from the body?
Responda
-
Liver metabolism
-
Renal excretion
-
Excreted in bile
-
Metabolism in muscles
Questão 50
Questão
How do macrocodes inhibit bacteria protein synthesis?
Responda
-
Bind to ‘A’ site, prevent initiation
-
Bind to ‘P’ site, prevent translocation
-
Bind to ‘E’ site, prevent translocation
-
Bind to ‘A’ site, prevent termination
Questão 51
Questão
What type of bacteria are macrocodes more efficacious against?
Responda
-
Gram -ve
-
Gram +ve
Questão 52
Questão
Macrocodes have poor oral bioavailability.
Responda
- True
- False
Questão 53
Questão
How are macrolides eliminated from he body?
Responda
-
Metabolised by liver
-
Renal excretion
-
Excreted in bile
-
Metabolism in muscles
Questão 54
Questão
At doses normally used in veterinary practice, erythromycin is bactericidal.
Responda
- True
- False
Questão 55
Questão
How do lincosamides inhibit bacteria protein synthesis?
Responda
-
Bind to 'A' site, prevent initiation
-
Bind to 'P' site, prevent elongation
-
Bind to 'E' site, prevent elongation
-
Bind to 'E' site, prevent termination
Questão 56
Questão
How do tetracyclines inhibit bacterial protein synthesis?
Responda
-
Bind to 'A' site, prevent initiation
-
Bind to 'P' site, prevent elongation
-
Bind to 'E' site, prevent elongation
-
Bind to 'E' site, prevent termination
Questão 57
Questão
Which class of bacteria are tetracyclines most effective against?
Responda
-
Gram +ve aerobes
-
Gram +ve anaerobes
-
Gram -ve aerobes
-
Gram -ve anaerobes
-
Wide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria
Questão 58
Questão
Tetracyclines have a bacteriostatic effect.
Responda
- True
- False
Questão 59
Questão
How are tetracyclines eliminated from the body?
Responda
-
Metabolism by the liver
-
Renal excretion
-
Excreted in bile
-
Metabolism by muscles
Questão 60
Questão
Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?
Responda
-
The drug is delivered directly to the site of action, minimising the systematic effect
-
The concentration is not high enough to affect mammalian cells
-
Mammalian cells do not efficiently transport tetracyclines across cell membrane
-
Tetracyclines on affect cells with a cell wall
Questão 61
Questão
How does chloramphenicol inhibit bacterial protein synthesis?
Responda
-
Binds to 'A' site, inhibits initiation
-
Binds to 'P' site, inhibits elongation
-
Inhibits peptide bond formation
-
Binds to 'E' site, inhibits termination
Questão 62
Questão
Chloramphenicol is banned in food-producing animals
Responda
- True
- False
Questão 63
Questão
Chloramphenicol had poor oral bioavailability.
Responda
- True
- False
Questão 64
Questão
Chloramphenicol can cross the BBB.
Responda
- True
- False
Questão 65
Questão
Chloramphenicol has a bacteriocidal effect.
Responda
- True
- False
Questão 66
Questão
How is chloramphenicol eliminated from the body?
Responda
-
Liver metabolism
-
Renal excretion
-
Excreted in bile
-
Metabolised in muscles
Questão 67
Questão
In which class of bacteria is chloramphenicol most efficacious?
Responda
-
Gram positive aerobes
-
Gram negative aerobes
-
Obligate anaerobes
-
Penicillinase producing - Staphylococcus
Questão 68
Questão
Which of the following drugs affect folate synthesis?
Responda
-
Cyclosporins
-
Chloramphenicol
-
Sulphonamides
-
Tetracycline
-
Trimethoprim
Questão 69
Questão
Which class of bacteria are sulphonamides most efficacious against?
Responda
-
Gram -ve anaerobes
-
Gram - aerobes
-
Gram +ve anaerobes
-
Gram +ve aerobes
-
Wide spectrum against Gram +ve and –ve bacteria
Questão 70
Questão
Sulphonamides have poor oral bioavailability.
Responda
- True
- False
Questão 71
Questão
Sulphonamides can cross the BBB.
Responda
- True
- False
Questão 72
Questão
How are sulphonamides excreted from the body?
Responda
-
Metabolised by the liver
-
Renal excretion
-
Excreted in bile
-
Metabolised by muscles
Questão 73
Questão
Sulphonamides have a bacteriostatic effect.
Responda
- True
- False
Questão 74
Questão
How does trimethoprim affect bacterial folate synthesis?
Responda
-
Inhibits uptake of p-aminobenzoic acid (PABA)
-
Inhibits dihydropteroate synthetase (DHPS)
-
Inhibits dihydropteroate reductase (DHPR)
-
Inhibits dihydrofolate synthetase (DHFS)
-
Inhibits dihydrofolate reductase (DHFR)
Questão 75
Questão
How are fluoroquinolones eliminated form the body?
Responda
-
Metabolised by liver
-
Renal excretion
-
Excreted in bile
-
Metabolised by muscles
Questão 76
Questão
Fluoroquinolones have poor oral bioavailability
Responda
- True
- False
Questão 77
Questão
Fluoroquinolones have a bactericidal effect.
Responda
- True
- False
Questão 78
Questão
Which class of bacteria is metronidazole most efficacious against?
Responda
-
Gram positive aerobes
-
Gram negative aerobes
-
Obligate anaerobes
-
Penicillinase producing Staphylococcus
Questão 79
Questão
Metronidazole has good oral bioavailability
Responda
- True
- False
Questão 80
Questão
Metronidazole can cross the BBB.
Responda
- True
- False
Questão 81
Questão
How is metronidazole eliminated from the body?
Responda
-
Metabolised by the liver
-
Renal excretion
-
Biliary excretion
-
Metabolised by muscles
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