Questão 1
Responda
-
has endocrine functions
-
is lined by a single layer of epithelial cells
-
is under endocrine control
-
absorbs more ions and molecules than it secretes
-
all of the above
Questão 2
Questão
The control of water excretion in the kidney is controlled by:
Responda
-
the antidiuretic hormone (ADH)
-
the medulla oblongata
-
blood plasma
-
sodium amount in the blood
-
potassium amount in the blood
Questão 3
Questão
The kidneys have a direct effect on which of the following?
Questão 4
Questão
Glucose reabsorption occurs in the:
Questão 5
Questão
Renin is secreted by:
Responda
-
cells in the macula densa
-
cells in the proximal tubule
-
cells in the distal tubule
-
juxtaglomerular cells
-
cells in the peritubular capillary bed
Questão 6
Responda
-
is promoted by reduced arteriolar stretch in. the glomeruli
-
increases when systemic arterial pressure rises
-
directly activates angiotensin converting enzyme
-
tends to expand the plasma volume
-
a and d
Questão 7
Responda
-
has both afferent and efferent arterioles
-
contains capillaries, which are at a higher hydrostatic pressure than the peritubular capillaries
-
filters 20% of the renal plasma flow
-
contains renin-secreting cells
-
all of the above
Questão 8
Questão
The acid-buffering power:
Responda
-
of HCO3- in blood is increased by respiratory control of pCO2
-
of haemoglobin exceeds that of HCO3- in blood
-
of HCO3- is increased by the action of carbonic anhydrase
-
of venous blood is normally greater than that of arterial blood
-
a, b, and d
Questão 9
Questão
Urinary volume is increased with:
Questão 10
Questão
The following occurs in the proximal tubule of the nephron:
Responda
-
reabsorption of all glucose
-
reabsorption of most water
-
active reabsorption of sodium
-
secretion of bicarbonate
-
a, b, and c
Questão 11
Questão
The antidiuretic hormone (ADH):
Responda
-
decreases the osmolarity of urine
-
decreases the volume of urine
-
increases the reabsorption of water in the proximal tubules
-
is synthesised in the posterior posterior pituitary gland
-
increases the excretion of glucose
Questão 12
Questão
Regarding the kidneys:
Responda
-
there are 1.3 million nephrons in each kidney
-
they produce aldosterone
-
they receive 12% of the cardiac output at rest
-
more blood flows through the renal cortex than the renal medulla
-
a, and d
Questão 13
Questão
Which of the following causes hyperkalemia
Questão 14
Questão
Glucose is reabsorbed:
Responda
-
by active transport
-
by passive transport
-
by Na+ co-transport
-
by H+ counter-transport
-
a, and c
Questão 15
Questão
Simulation of the sympathetic nerves cause the following effects;
Responda
-
low diuresis
-
decreased net filtration pressure
-
increased glucose urine level
-
decreased glucose urine level
-
a, and b
Questão 16
Questão
The glomerular capillaries have the following functions:
Questão 17
Questão
Obligatory water loss from the body is:
Responda
-
400 ml in faeces
-
300 ml from the lungs
-
loss from skin & lungs
-
insensible water loss
-
500 ml in urine
Questão 18
Questão
Blood flow at rest is most for:
Responda
-
brain
-
liver
-
kidneys
-
heart
-
skin
Questão 19
Questão
Renal blood flow is dependent on:
Questão 20
Questão
Which of the following substances has the highest renal clearance?
Responda
-
PAH
-
Glucose
-
Urea
-
Water
-
Insulin
Questão 21
Questão
The ascending limb of the loop of Henle is:
Responda
-
impermeable to Na+
-
involved in active transport of K+ into the lumen
-
involved in active transport of Cl- out of lumen
-
involved in active transport of Na+ into lumen
-
hypotonic at the top
Questão 22
Questão
Which of the following ls involved in the regulation of glomerular filtration rate (GFR)?
Questão 23
Questão
Water excretion by the kidney is due to:
Questão 24
Responda
-
Erythropoietin
-
ADH
-
Angiotensin ll
-
ANP
-
Cholecalciferol
Questão 25
Questão
Increase in GFR occurs when there is:
Questão 26
Questão
The clearance (or ‘renal regulation') of which one of the following is not regulated by a hormone:
Responda
-
sodium
-
potassium
-
calcium
-
phosphate
-
sulphate
Questão 27
Questão
The kidneys filter from the blood every day about:
Responda
-
1000 ml
-
180 l
-
18 l
-
50 l
-
8 l
Questão 28
Questão
Direct control of water excretion in the kidney is controlled by:
Questão 29
Questão
Kidneys have a direct effect on which of the following:
Questão 30
Questão
The countercurrent exchange system includes:
Responda
-
glomerulus and macula densa
-
proximal convoluted tubule and distal convoluted tubule
-
loop of Henle and collecting tubule
-
afferent arteriole and efferent arteriole
-
ureters and bladder
Questão 31
Questão
Tubular reabsorption of a filtered substance is likely to be active rather than passive if:
Responda
-
its concentration in the tubular fluid is lower than in peritubular capillary blood
-
is carried out by the mechanism of simple diffusion
-
renal clearance is lower than that of insulin
-
renal clearance rises at low plasma levels
-
osmolality there is higher than the plasma one
Questão 32
Questão
The renal clearance of a substance:
Responda
-
is inversely related to its urinary concentration, U
-
is directly related to the rate of urine formation, and is expressed in units of volume per unit time
-
is directly related to its plasma concentration, P
-
is expressed in mm Hg
-
must fall in the presence of metabolic poisons
Questão 33
Questão
In the fluid in the distal part of the proximal convoluted tubule:
Responda
-
urea concentration is higher than in Bowman’s capsule
-
pH is less than 6 when the kidneys are excreting an acid urine
-
glucose concentration is similar to that in plasma
-
osmolality is about 25 per cent that of glomerular filtrate
-
bicarbonate concentration is higher than in plasma
Questão 34
Questão
Renal tubules normally reabsorb:
Responda
-
fluids with osmolality lower than the plasma one
-
all filtered HCO3- in respiratory alcalosis
-
substances closely related to Cl-
-
all filtered plasma proteins
-
more K+ and Cl-
Questão 35
Questão
In the nephron, the osmolarity or the fluid in the:
Responda
-
Tip of the loop Of Henle is less than that of plasma
-
Bowman's capsules is less than that in the distal tubules
-
Collecting duct rises when vasopressin is being secreted
-
Proximal convoluted tubule rises along its length
-
Proximal tubule is with lower osmolality than plasma one
Questão 36
Questão
Transport maximum (Tm) - limited reabsorption of a substance implies that its:
Responda
-
reabsorption is active
-
reabsorption is critically related to tubular transit time
-
reabsorption is passive
-
renal clearance falls with its plasma concentration
-
reabsorbtion is carried out by the mechanism of faciliated diffusion
Questão 37
Questão
When a patient’s mean arterial blood pressure falls by 50%
Responda
-
renal blood flow increases
-
glomerular filtration increases
-
there is a decrease in the circulating aldosterone level
-
renal vasoconstriction occurs
-
urinary output is increased
Questão 38
Questão
The cells of the distal convoluted tubule:
Responda
-
reabsorb about 50 % of the water filtered by the glomeruli
-
reabsorb all filtered aminoacide
-
reabsorb all filtered proteins
-
reabsorb sodium in exchange for hydrogen or potassium ions
-
determine the final composition of urine
Questão 39
Questão
Renal blood flow falls:
Responda
-
about 10 % when arterial pressure increases 10% above normal
-
about 5% when metabolic activity in the kidney falls by 5%
-
during emotional stress
-
after small haemorrhage
-
gradually from the inner medulla to the outer cortex per unit weight of tissue
Questão 40
Responda
-
and glucose have different molar concentrations in normal blood
-
clearance is higher, than creatinins one
-
is actively secreted by the renal tubular cells into the tubular fluid
-
concentration in blood may rise ten-fold after a high protein meal
-
causes diuresis when its blood concentration is increased
Questão 41
Questão
The renal clearance of:
Responda
-
Inulin provides an estimate of glomerular filtration rate
-
Chloride increases after an injection of aldosterone
-
PAH falls when the PAH load exceeds the Tm for PAH
-
Urea is higher than that of insulin
-
Inulin is dependent of its plasma concentration
Questão 42
Responda
-
is a steroid hormone, secreted by the adrenal medulla
-
production ceases following removal of the kidneys and their juxtaglomerular cells
-
production decreases in treatment with drugs which block angiotensin-converting enzyme
-
secretion results in increased potassium reabsorption by the nephron
-
secretion results in a fall in plasma volume
Questão 43
Questão
In healthy people, urinary:
Responda
-
clearance of glucose differs 0, if its plasma concentration is below 11,1mmol.1-1
-
osmolality ranges from 200-400 mosmol/litre
-
colour is due to small quantities of bile pigments
-
pH falls as dietary protein rises
-
calcium excretion is decreased by parathormone
Questão 44
Questão
The renal clearance
Responda
-
glucose is above 0, if the plasma concentration of a given substance is below 11, mmol.1-1
-
of urea is higher than creatinin‘s one
-
of glucose provides an estimate of renal plasma flow
-
of phosphate is decreased by parathormone
-
of protein is normally zero
Questão 45
Questão
Secretion of renin:
Responda
-
occurs in the stomach during infancy
-
is stimulated by the hormone angiotensin 1
-
is stimulated by a fall in extracellular fluid volume and leads to raised levels of angiotensin II in the blood
-
inhibits the secretion of aldosterone
-
inhibits ACTH secretion by the pituitary gland
Questão 46
Questão
Diabetes insipidus (deficiency of antldiuretic hormone) causes a fall in the:
Responda
-
osmolality of the urine
-
reabsorption of water from the proximal tubules
-
extracellular but not intracellular fluid volume
-
extracellular fluid osmolality
-
intracellular fluid osmolality
Questão 47
Questão
Dialysis fluid used in the treatment of renal failure should contain the normal plasma levels of:
Responda
-
urea
-
potassium
-
osmolarity
-
plasma proteins
-
hydrogen ions
Questão 48
Questão
Long-standing obstruction of the urethra may cause:
Responda
-
enlargement of the prostate gland
-
dystrophy of the bladder muscle
-
dilation of the ureters and reduction of the glomerular filtration rate
-
increase and reduction of the glomerular filtration rate
-
a decrease in residual volume in the bladder
Questão 49
Questão
Emptying of the bladder may be less effective if:
Responda
-
the sympathetic nerves carrying afferent information from bladder to the spinal cord are cut
-
the pelvic nerves are cut or anticholinergic drugs are administered
-
cholinergic agonists are administered
-
alpha-adrenergic receptor antagonists are administered
-
beta-adrenergic receptor blockers are administered
Questão 50
Questão
Drugs which interfere with active transport of sodium in the proximal tubule tend to increase:
Responda
-
urine production
-
plasma osmorality
-
chloride reabsorbtion
-
intestinal fluid volume
-
plasma volume
Questão 51
Questão
A drug which inhibits carbonic anhydrase:
Responda
-
decreases bicarbonate formation and reabsorption in the kidney
-
increases plasma bicarbonate levels
-
increases blood pH
-
increases urinary loss of potassium ions
-
increases urinary volume and pH
Questão 52
Questão
A patient with chronic renal failure usually has:
Responda
-
an increased blood urea and blood uric acid
-
a decreased blood uric acid
-
an increased creatinine clearance
-
an increased acid-base disturbance when he or she vomits
-
an increased acid-base problem on a low protein diet
Questão 53
Questão
Cutting the sympathetic nerves to the bladder may cause:
Responda
-
difficulty in emptying the bladder
-
loss of tone in the internal sphincter of the bladder and loss of pain sensation in the bladder
-
loss of tone in the external sphincter of the bladder
-
increased pain sensation in the bladder
-
infertility in the female
Questão 54
Questão
Sudden (acute) renal failure differs from gradual (chronic) renal failure in that:
Responda
-
potassium retention tends to be more severe
-
blood urea levels tend to be higher
-
depression of bone marrow activity is unlikely to occur
-
metabolic acidosis is usually not a problem
-
dietary protein restriction is unnecessary
Questão 55
Questão
A long-standing increase in arterial pCO2 (respiratory acidosis) leads to:
Responda
-
an increase in renal bicarbonate formation
-
a decrease in urinary ammonium salts
-
a decrease in plasma potassium concentration
-
an increase of the monohydrogen/dihydrogen phosphate ratio in urine
-
a decrease in urinary bicarbonate excretion
Questão 56
Questão
The inhibition of the antidiurctic hormone (ADH), say by alcohol, would have what affect?
Responda
-
constriction of the afferent arteriole
-
inhibition of diuresis
-
stimulation of water conservation
-
constriction of the efferent arteriole
-
reduction in water conservation by the kidneys
Questão 57
Questão
Reabsorption of amino acids from the filtrate requires many different protein carriers because:
Responda
-
denaturation may occur
-
this transport is not competitive
-
there are only 10 different amino acids
-
transport of amino acids is typically highly specific
-
glucose inhibits amino acid transport
Questão 58
Questão
Reabsorption (transport) of both N a‘“ and glucose together from the renal lumen is an example of:
Responda
-
facilitated diffusion
-
secondary passive transport
-
primary direct active transport
-
secondary indirect active antiport
-
secondary indirect active symport
Questão 59
Questão
Drinking a litre of water:
Responda
-
increases secretion of antidiuretic honnone
-
reduces the plasma sodium concentration
-
increases osmolarity of the urine
-
causes body cells to shrink
-
decreases the specific gravity of the body
Questão 60
Questão
An acid-base buffer system:
Responda
-
can be a mixture of a weak acid and its conjugate base
-
can be a solution of sodium and bicarbonate ions
-
prevents any change in pH when acid is added
-
works best when acid and base are equal in concentration
-
is hemoglobin as an example of intracellular buffer
Questão 61
Questão
Acidosis in a patient may lead to:
Responda
-
increased urinary excretion of potassium
-
hypoventilation
-
a blood pH of less than 5.5
-
an urinary pH of less than 5.5
-
tetany
Questão 62
Questão
A rise in the osmolality of extracellular fluid may lead to:
Responda
-
thirst and release of vasopressin
-
increased water reabsorption in the proximal convoluted tubules
-
a decrease of vasopressin secretion
-
an increase in intracellular fluid volume
-
suppression of sweat secretion
Questão 63
Questão
A raised blood pH and bicarbonate level is consistent with:
Responda
-
metabolic acidosis
-
partly compensated respiratory alkalosis
-
a reduced pCO2
-
chronic renal failure with a raised pCO2
-
a history of persistent vomiting of gastric contents
Questão 64
Questão
A patient with partly compensated respiratory acidosis:
Responda
-
must have a raised pCO2
-
must have a raised bicarbonate concentration [HCO3-]
-
may have evidence of renal compensation
-
may have respiratory failure due to hypoventilation
-
all of the above
Questão 65
Questão
Sodium retention:
Responda
-
occurs for several days after major surgery
-
expands the extracellular fluid volume
-
expands the blood volume
-
increases the severity of oedema
-
all of the above
Questão 66
Questão
Sodium depletion differs from water depletion in that:
Responda
-
cardiovascular changes are less pronounced
-
intracellular fluid volume is less affected
-
the haematocrit increases
-
thirst is more severe
-
antidiuretic hormone levels are higher
Questão 67
Questão
A high blood potassium level (hyperkalaemia):
Responda
-
occurs in acute renal failure
-
follows severe crush injuries to the limbs
-
may diminish cardiac performance and cause death
-
may be reduced by Intravenous infusion of insulin and glucose
-
all of the above
Questão 68
Questão
A raised level of calcium in the blood (hypercalcaemia):
Responda
-
may occur when parathyrord activity decreases
-
may occur when the plasma protein level falls
-
may occur in chronic renal failure
-
increases the risk of stone formation in the urinary tract
-
causes increased excitability of nerve and muscle
Questão 69
Questão
Thirst is stimulated by:
Responda
-
increase in plasma osmolality and volume
-
increase in plasma osmolality and decrease in volume
-
decrease in osmolality and increase in volume
-
decrease in plasma osmolality and volume
-
increase in intracelular volume