Malignancies

Descrição

Pathophysiology and pharmacology of malignancies lecture
Mark George
Quiz por Mark George, atualizado more than 1 year ago
Mark George
Criado por Mark George mais de 10 anos atrás
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Resumo de Recurso

Questão 1

Questão
Which of the following are features of cancer cells?
Responda
  • autonomic & immortal
  • static & aplastic
  • transformational & variable
  • anaplastic & lacking apoptosis

Questão 2

Questão
Which of the following can act as tumor markers?
Responda
  • proteins
  • vitamins
  • hormones
  • antibodies
  • antigens

Questão 3

Questão
Tumor markers can confirm diagnosis of some cancers.
Responda
  • True
  • False

Questão 4

Questão
Which of the statements below is FALSE?
Responda
  • Pheochromocytoma is a tumor of the adrenal medulla.
  • Adrenaline can act as a tumor marker.
  • PSA is a tumor marker specifically for prostate cancer
  • Tumor markers can be found in blood, urine and CSF.

Questão 5

Questão
Gene mutations can result in...... (Select the INCORRECT answer)
Responda
  • Repeated division of telomeres.
  • Activation of tumor suppression genes.
  • Cancer cells stimulating angiogenesis
  • Stimulation of growth promotion pathways
  • Transformation of proto-oncogenes into oncogenes.

Questão 6

Questão
Regarding the contribution of obesity to cancer, which of the following statements are true?
Responda
  • BMI greater than 30 linked to cancer.
  • The endocrine and metabolic activity of adipose tissue is thought to contribute to cancer development
  • The increased release of FFA and TNF is thought to contribute to cancer development
  • Increased levels of insulin is also linked to cancer development.

Questão 7

Questão
Which of the following sets of factors all increase the risk of cancer development?
Responda
  • CHronic inflammation, over-exertion, poor diet and television.
  • Viruses, bacteria, chronic inflammation and environmental factors
  • smoking, radiation, alcohol and shopping
  • Ulcerative colitis, chronic asthma, physical inactivity and Epstein Barr Virus

Questão 8

Questão
Select the true statements regarding pharmacological management of cancer.
Responda
  • Narcotic analgesics act to inhibit the release of substance P
  • Adverse effects of narcotic analgesics include diarrhoea, psychological disturbances and vomiting
  • Fentanyl is slow to act but has a long half life.
  • Accumulation of morphine can result in coma
  • Buprenorphine and azathioprine are used in the treatment of terminal cancer pain

Questão 9

Questão
Select the cytotoxic agents
Responda
  • Calcium channel blockers
  • Antiarbitrucins
  • Antimetabolites
  • Alkylating agents
  • Hormonal agonists
  • Hormonal inhibitors

Questão 10

Questão
Chlorambucil and Carboplatin target the mechanism for cell division
Responda
  • True
  • False

Questão 11

Questão
The antiandrogenic drug Flutamide is administered to prostate cancer sufferers.
Responda
  • True
  • False

Questão 12

Questão
5-fluorouacil (5-FU) is an hormonal inhibitor that acts by blocking synthesis of pyramidine nucleotides
Responda
  • True
  • False

Questão 13

Questão
Side effects common to alkylating agents, antibiotic-type agents and antimetabolites include
Responda
  • Bone marrow suppression
  • GI disturbances
  • mouth ulcers
  • impaired fertility
  • bleeding

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