Question 1
Question
What’s the most common type of heart disease, and leading cause of death?
Question 2
Question
There are two major categories of stroke. 80% are which one?
Question 3
Question
Platelets are disc-shaped fragments produced by __________.
Answer
-
Megakaryotes
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Megakaryocytes
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Minikaryocytes
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Minikaryotes
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Spleen
-
Blasts
Question 4
Question
Average platelet count is:
Answer
-
150,000 – 400,000 / μL
-
150 – 400 / μL
-
1,500 – 4,000 / μL
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15,000 – 40,000 / μL
-
150,000 – 40,000 / μL
Question 5
Question
Which of the following are functional responses of platelets?
Answer
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Primary adhesion
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Shape change
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Aggregation
-
Granule release
-
Procoagulant function
-
Anticoagulant function
-
Secondary adhesion
-
Antiapoptotic function
-
Proapoptotic function
-
Carry Oxygen
Question 6
Question
Shape change is a crucial functional response of platelets to …something. They change shape from [blank_start]__________[blank_end] to [blank_start]__________[blank_end]
Answer
-
Flat disc
-
Spiny disc
-
Spiny sphere
-
Smooth sphere
Question 7
Question
Which receptor/ligand interactions occur during which bit?
Answer
-
GPIb/V/IX – vWF
-
αIibβ3 – fibronectin, VWF
-
αIibβ3 – fibrinogen, fibronectin
-
GPIb/V/IX – vWF
-
αIibβ3 – fibronectin, VWF
-
αIibβ3 – fibrinogen, fibronectin
-
GPIb/V/IX – vWF
-
αIibβ3 – fibronectin, VWF
-
αIibβ3 – fibrinogen, fibronectin
Question 8
Question
Fibrin generation at the site of vascular injury has a crucial role in anchoring the thrombus to the vessel. It requires initiation of coagulation and generation of thrombin. This depends on Tissue Factor (TF) expression on the surface of [blank_start]__________[blank_end] and fibroblasts.
Answer
-
Smooth Muscle Cells (SMCs)
-
Vascular Endothelial Cells (VECs)
-
Vascular Epithelial Cells (VECs)
-
Skeletal Muscle Cells (SMCs)
-
Cardiac Muscle Cells (CMCs)
Question 9
Question
Platelet-mediated fibrin clot retraction shrinks the size of the blood clot. Thought to be important for stabilising the clot against shear forces of blood flow. This requires:
Answer
-
Integrin αIIbβ3
-
Fibrin
-
Myosin/contractile force
-
Actin cytoskeleton
Question 10
Question
Which of the following are prothrombotic and which are antithrombotic?
ADP: [blank_start]__________[blank_end];
Aspirin: [blank_start]__________[blank_end];
Epinephrine: [blank_start]__________[blank_end];
Clopidogrel: [blank_start]__________[blank_end];
Collagen: [blank_start]__________[blank_end];
Heparin: [blank_start]__________[blank_end];
Thrombin: [blank_start]__________[blank_end];
Answer
-
Pro
-
Anti
-
Anti
-
Pro
-
Pro
-
Anti
-
Anti
-
Pro
-
Pro
-
Anti
-
Anti
-
Pro
-
Pro
-
Anti
Question 11
Question
Does Aspirin prevent initial platelet adhesion?
Question 12
Question
Does Aspirin prolong skin bleeding time?
Question 13
Question
What’s the efficacy of Aspirin?
Answer
-
~5-10%
-
~15%
-
~25%
-
~30-50%
-
~50-70%
-
~75%
-
~85%
-
~90-95%
Question 14
Question
Does Aspirin inhibit prostacyclin synthesis?
Question 15
Question
Does Aspirin stimulate prostacyclin synthesis?
Question 16
Question
Does Aspirin suppress the release of thrombogenic factors from platelets?
Question 17
Question
Integrin αIibβ3 (GPIIbIIIa) inhibitors are:
Answer
-
Antithrombotic (but can cause severe bleeding)
-
Prothrombotic (but can cause severe bleeding)
-
Antithrombotic (but can't cause severe bleeding)
-
Prothrombotic (but can't cause severe bleeding)
Question 18
Question
Which of the following are CURRENT (not further potential) antithrombotic treatments:
Question 19
Question
PAR antagonists are under development as a potential novel antithrombotic. What’s PAR?
Answer
-
Protease-Activated Receptor
-
Protease-Antigen Receptor
-
Protease-Antagonist Receptor
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Protease-Agonist Receptor
-
Protease-Activating Receptor