11544540
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
almost 7 years ago
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Question 1
Answer
-
Skeletal Muscle
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Adipose Tissue
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Liver
Question 2
Question
Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?
Answer
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Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
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Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Question 3
Question
Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?
Answer
-
Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
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Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
-
Protein degradation (all tissues)
-
Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Question 4
Question
Definition of Insulin Resistance. There are three of them. Which is which?
“The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the [blank_start]__________[blank_end] definition.
Answer
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Clinical
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“Sometimes”
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Experimental
Question 5
Question
Loss of function of IR in skeletal muscle results in which of the following:
Answer
-
Reduced Skeletal Muscle glucose uptake
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Whole-body glucose intolerance and insulin resistance
Question 6
Question
Insulin resistance results from a fuck-up in which of the following:
Answer
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Insulin Receptor
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Insulin Transporter
Question 7
Question
Loss of function of Glut4 in Skeletal Muscle results in which of the following:
Answer
-
Reduced Skeletal Muscle glucose uptake
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Whole-body glucose intolerance and insulin resistance
Question 8
Question
Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:
Answer
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MIRKO
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FIRKO
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LIRKO
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AIRKO
Question 9
Question
True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.
Answer
- True
- False
Question 10
Question
True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.
Answer
- True
- False
Question 11
Question
True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.
Answer
- True
- False
Question 12
Question
Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:
Answer
-
Reduced adipocyte glucose uptake
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Reduced insulin suppression of HGP
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Increased insulin suppression of HGP
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Whole-body glucose intolerance and insulin resistance
Question 13
Question
LIRKO results in which of the following:
Answer
-
Loss of insulin suppression of HGP
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Whole-body glucose intolerance and insulin resistance
Question 14
Question
HGP = ??
Answer
-
Hepatic Glucose Production
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HypoGonadotroPin
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Haematic Glucose Production
Question 15
Question
“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:
Answer
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Reduced Insulin Receptor (IR) levels
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Reduced Glut4 levels
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Inappropriate translocation of Glut4 to the plasma membrane
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Inappropriate translocation of IR to the plasma membrane
Question 16
Question
Insulin resistance is caused by many factors including:
Answer
-
Ectopic lipid deposition
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Inflammation
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Mitochondrial oxidative stress
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