Question 1
Question
Granulation tissue appearance includes [blank_start]capillary sprouts[blank_end] from venular endothelium
--> perpendicular to the wound surface, leaky ([blank_start]oedema[blank_end], [blank_start]exudate[blank_end] (protein rich).
--> [blank_start]Fibroblasts[blank_end] growing in from sides and base of wound: makes collagen type 3 then 1, change phenotye to [blank_start]myofibroblast[blank_end] ( wound [blank_start]contraction[blank_end] ), hyaluronic acid and sulfated proteoglycans made.
Answer
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capillary sprouts
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oedema
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exudate
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Fibroblasts
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myofibroblast
-
contraction
Question 2
Question
Bone fracture is a bone lesion which leads to bone discontinuity
Question 3
Question
Bone repair depends on;
Type of [blank_start]break[blank_end] - Result of strength & direction of applied force --> [blank_start]axial[blank_end] force (compressional fracture), Torsion force ([blank_start]spiral[blank_end] fracture), Combined [blank_start]torsion[blank_end] and compressional force leads to an [blank_start]angel[blank_end] and displaced fracture
Adjacent tissue damage effects [blank_start]rate[blank_end] of repair. (e.g muscles)
Answer
-
break
-
axial
-
spiral
-
torsion
-
angled
-
rate
-
growth
-
deterioration
Question 4
Question
which one of these are bone repair host factors?
Question 5
Question
healing of bone is triphasic
Question 6
Question
Healing of bone phases
1: [blank_start]Inflammatory phase[blank_end]
2: Reparative
3: [blank_start]Remodelling[blank_end]
Answer
-
Inflammatory phase
-
Remodelling
Question 7
Question
What would most likely to occur after 2 days of bone injury?
Question 8
Question
Callus formation into chondrocytes is in remodelling phase of bone repair.
Question 9
Question
Bone Callus is a collar of [blank_start]osteogenic[blank_end] cells around a bone fracture. Has the same function as granulation tissue.
Question 10
Question
In the reparative phase (II) of bone repair, Trabeculae of [blank_start]cancellous[blank_end] bone slowly unite. There's [blank_start]capillary[blank_end] ingrowth from edge of marrow cavity. [blank_start]Osteoblasts[blank_end] differentiate, cancellous bone laid down. [blank_start]Fibrocartilage[blank_end] formed in less vascular areas. After long periods of time, [blank_start]osteoclasts[blank_end] start to remodel. Marrow slowly replaced.
Answer
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cancellous
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dense
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capillary
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veins
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Osteoblasts
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chondroblasts
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Fibrocartilage
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Hyaline cartilage
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osteoclasts
Question 11
Question
In [blank_start]Remodelling[blank_end] phase (III) of bone repair, it may take years. Bone contours are re-organised and excess [blank_start]callus[blank_end] removed.
Answer
-
callus
-
scar tissue
-
Remodelling
-
Inflammatory
-
Reparative
Question 12
Question
What happens after weeks of bone repair?
Answer
-
Chondrocytes multiply
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All cancellous bone converted of to lamellar bone
-
Chondrocytes mineralises & dies after callus is vascularised
-
It is the remodelling phase, callus is removed
Question 13
Question
Surgical incisions in bone --> healing with minimal [blank_start]callus[blank_end] formation and minimal disruption to the bone's ordered structure
Question 14
Question
Neuronal cells are mitotic and can be replaced
Question 15
Question
What is Gliolisis?
Question 16
Question
In PNS (Peripheral nervous system), nerve axons can be [blank_start]replaced[blank_end]. If Basement membrane of [blank_start]Schwann[blank_end] is disrupted, resorbed axons may miss each other resulting in a traumatic [blank_start]neuroma[blank_end]. If they are [blank_start]intact[blank_end], axonal growth has path to follow.
Answer
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replaced
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Schwann
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myelin sheath
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neuroma
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neuroblastoma
-
carcinoma
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intact
-
removed
Question 17
Question
When basement membrane is intact; (PNS)
Answer
-
Growth of axonal sprouts from surviving stumps begin at 4mm/day
-
There is no axonal sprout growth.
-
Myelin sheath breaks down around axonal tip
Question 18
Question
Tissue healing in liver - acute injury heals by complete regeneration, whilst chronic is usually leading to collapse of reticulin framework, along with surrounding by fibrosis also known as CIRRHOSIS.
Question 19
Question
Which one of these are correct in regards to tissue healing in kidneys?
Answer
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Tubular epithelium can regenerate after damage
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Glomeruli can regenerate - No scar tissue
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Glomeruli cannot regenerate - Scar tissue formed
Question 20
Question
Metaplasia is a form of healing in epithelial surfaces
Question 21
Question
An example of metaplasia includes replacement of ciliated columnar epithelium to squamous type that is resistant to trauma in chronic smoking damaged individuals.
Question 22
Question
Cardiac muscle cells are permanent and does not regenerate. Repairs by fibrosis
Question 23
Question
Skeletal muscle has no ability of healing/regeneration at all.
Question 24
Question
Smooth muscle has limited regeneration - can regenerate if loss is minimal
Question 25
Question
Respiratory epithelium [blank_start]can[blank_end] regenerate. However, basement membrane must be intact and CT framework minimally disrupted. If basement membrane disrupted, [blank_start]fibrosis[blank_end] occurs.
Answer
-
can
-
cannot
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fibrosis
-
inflammation
Question 26
Question
Which one(s) of these answers are true of cartilage healing?
Answer
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Will replace itself by superficial ulceration if damage is small
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Cannot replace itself
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Extensive damage may have resultant haematoma following fibrosis
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Undergoes aplastic changes
Question 27
Question
Regeneration is good in tendon healing