Bleeding Disorders & Venous Thrombosis

Vitamin K is essential for the activation of which four coagulation factors?

Haemophilia A is a deficiency of Factor [blank_start]VIII[blank_end] Haemophilia B is a deficiency of Factor [blank_start]IX[blank_end]

All clotting factors are produced in which organ? The [blank_start]liver[blank_end]

In terms of dietary intake, Vitamin K deficiency can occur in those who consume low amounts of [blank_start]green, leafy foods[blank_end]

Vitamin K requires the presence of [blank_start]Bile[blank_end] salts in order to be successfully absorbed in the intestines.

All babies are given an injection of [blank_start]Vitamin K[blank_end] at birth to prevent the development of Haemorrhagic Disease of the Newborn

A man presents to A&E after being hit by a lorry whilst riding his motorbike. Multiple severe fractures are found by the attending doctors. After a short period of time in the hospital the nurses start to notice that the man is bleeding from his venflon sites and has also developed a diffuse purpura. What condition is this man likely suffering from? [blank_start]Disseminated Intravascular Coagulation[blank_end]

How should DIC be treated in acute care?

Prothrombin time tests for the presence of which coagulation factor?

Activated Partial Thromboplastin Time (APTT) tests for the presence of which two clotting factors?

The enzyme prothrombinase comprises which two coagulation factors?

D-dimers are the main degradation product of which of the following structures?

[blank_start]Hypovolaemic[blank_end] shock is one of the common causes of Disseminated Intravascular Coagulation

What inheritance pattern does haemophilia (both A and B) typically follow?

Which type of Haemophilia is most common?

Which two joints are typically affected by bleeds in haemophilia patients, leading to haemarthrosis?

Haemophilia affects ...

Venous thrombosis is a low pressure system whereby only the [blank_start]secondary[blank_end] haemostatic system is activated, leading to a rich [blank_start]fibrin[blank_end] clot.

Virchow's Triad:

Pulmonary embolism usually presents in a patient as a specific type of chest pain, described as [blank_start]pleuritic[blank_end] chest pain

Thrombophilia is a known risk factor for deep vein thrombosis

Oestrogen therapy increases the risk of an individual suffering a DVT

Which clotting factor does Von WIllebrand Factor bind to in the blood, thus preventing its degradation?

Define Thrombophilia: [blank_start]Increased tendency to develop clots[blank_end]

Thrombophilia screening should be considered for a patient who has experienced a DVT below the age of [blank_start]45[blank_end]

Warfarin is an antagonist of [blank_start]Vitamin K[blank_end]

Thus, Warfarin treatment obstructs the action of which four of the following clotting factors?

Long term coagulation, whilst reducing the risk of thrombosis also in turn reduces the risk of a serious haemorrhage occurring

A 37 year old woman presents to her GP after her 3rd miscarriage in the past 4 years. She is desperate for help and doesn't think she can go through the emotional stress of another miscarried pregnancy. Her only past medical history of note is asthma and two previous Deep Vein Thromboses. What condition is the woman likely suffering from? [blank_start]Antiphospholipid Syndrome[blank_end]

Which of the following autoantibodies is a strong indicator of antiphospholipid syndrome?

Which of the following treatment regimes would be suitable for a patient with antiphospholipid syndrome?

[blank_start]Tranexamic[blank_end] acid is a medication used to treat or prevent excessive blood loss in cases of major trauma.