Haemopoiesis

Primary haemostasis = [blank_start]Platelet plug[blank_end] Secondary Haemostasis = [blank_start]FIbrin clot[blank_end]

PLatelets are formed on the surface of which cell type? [blank_start]Megakaryocyte[blank_end] Cells

Lifespan of certain cells: Red blood cells = [blank_start]120 days[blank_end] Neutrophils = [blank_start]7-8 hours[blank_end] Platelets = [blank_start]7-10 days[blank_end]

Thus, in bone marrow failure disorders, which of the follow cell types would be the first to decrease?

Red cell precursors are called [blank_start]reticulocytes[blank_end]

From which progenitor cells do each of the following cell types arise? B Cells - [blank_start]Lymphoid progenitor Cells[blank_end] Neutrophil - [blank_start]Myeloid Progenitor Cells[blank_end] Erythrocyte - [blank_start]Myeloid Progenitor Cells[blank_end] Dendritic Cells - [blank_start]Lymphoid Progenitor Cells[blank_end]

Embryonically, haemopoietic stem cells originate in the [blank_start]mesoderm[blank_end]

The first sign of erythroid activity as haemopoiesis occurs in the [blank_start]yolk[blank_end] sac

Haemopoiesis begins in which organ by week 6? The [blank_start]liver[blank_end] It then begins in the bone marrow by week [blank_start]16[blank_end]

In adults, haemopoiesis is restricted to the marrow within axial skeleton, pelvis and proximal long bones

From which anatomical site is a bone marrow biopsy typically taken? [blank_start]Posterior Iliac Crest[blank_end]

In contrast to [blank_start]capillaries[blank_end], [blank_start]venous sinuses[blank_end] are larger and have a discontinuous basement membrane

The gaps between endothelial cells through which blood cells can enter the circulation are called [blank_start]fenestrations[blank_end]

[blank_start]Red[blank_end] bone marrow is haemopoietically active [blank_start]Yellow[blank_end] bone marrow is haemopoietically inactive and contains mostly fat

There is an increase in [blank_start]yellow[blank_end] bone marrow with age

[blank_start]Thrombopoietin[blank_end] regulates growth and development of megakaryocytes from their precursors

Label the cell types shown below (e.g. neutrophil, lymphocyte, eosinophil, basophil, etc)

In terms of investigating haemopoiesis: For [blank_start]non-lymphoid cells[blank_end], the full blood count and morphological assessment of blood cells is often sufficient for diagnosis For [blank_start]lymphoid cells[blank_end], the expression of antigens indicating the lineage or developmental stage of the cell is required for diagnosis

In order to investigate lymphocytes for diagnosis, a study of antigen expression using specific antibodies must be conducted. This process is called [blank_start]Immunophenotyping[blank_end]