Copy and Edit

Clinical Pharmacology Final MCQs- 5th Year PMU

Description

Clinical Pharmacology Final MCQs- 5th Year PMU
Med Student
Quiz by Med Student , updated more than 1 year ago
Med Student
Created by Med Student almost 5 years ago
1458
7
0

Resource summary

Question 1

Question
Drugs half-life is an index for
Answer
  • the route of administration of the drug
  • the duration of the drug effect when there is a relationship between it and plasma concentrations
  • time to reach steady-state plasma concentration after repeated administration
  • determination of dose interval

Question 2

Question
Irrational ready-made drug formulations contain
Answer
  • drugs withdifferent half-life
  • drugs for etiotropic and symptomatic treatment
  • drugs with narrow therapeutic window
  • drugs affecting different pathogenic mechanisms

Question 3

Question
Drug surveillance is done by
Answer
  • spontaneous reporting
  • observation studies
  • family doctors
  • population statistics

Question 4

Question
Adverse drug reactions are the following types
Answer
  • augmented
  • bizarre
  • chronic
  • delayed

Question 5

Question
Drugs contraindicated in the first half of pregnancy are
Answer
  • Erythromycin
  • Sex steroids
  • Penicillins
  • Oral anticoagulants

Question 6

Question
For pharmacokinetics in elderly is true
Answer
  • decreased excretion
  • decreased metabolism
  • decreased volume of distribution
  • increased volume of distribution

Question 7

Question
Reasons for inadequate pharmaceutical availability are
Answer
  • chronic renal failure
  • improper use of the drug formulation
  • bad quality of the drug substance
  • participating in treatment

Question 8

Question
First phase of clinical trial can be determinated as
Answer
  • first application of a new substance to healthy volunteers
  • first application of a new substance to patients
  • efficacy and safety in a large number of patients
  • post-marketing surveillance in thousands of patients

Question 9

Question
Monitoring of therapeutic plasma concentrations is necessary for
Answer
  • theophyllin
  • phenobarbital
  • carbamazepin
  • amoxicillin

Question 10

Question
Pharmacogenetic differences lead to
Answer
  • decreased effect
  • increased effect
  • development of adverse drug reactions
  • avitaminosis

Question 11

Question
Placebo is
Answer
  • allergic drug reaction
  • drug form, without active substance
  • method for treatment of acute pain
  • drug tolerance

Question 12

Question
Nocebo effect is
Answer
  • Allergic drug reaction
  • Analgesic method
  • Adverse drug reaction, caused by placebo
  • CNS depression

Question 13

Question
When patient and doctor are aware of the contents of the formulation, the trial is defined as
Answer
  • open trial
  • blind trial
  • placebo trial
  • double blind trial

Question 14

Question
Binding of drugs with plasma proteins is important for
Answer
  • half- life
  • drugs interactions
  • bioavailabillity
  • the value of the pharmacological effect

Question 15

Question
Adverse drug reactions lead to
Answer
  • increased pharmacological effect
  • decreased risk of toxicity
  • decreased efficacy of the treatment
  • development of unpredictable drug effects

Question 16

Question
Tobacco smoking
Answer
  • increases drugs metabolism
  • decreases drug metabolism
  • decreases plasma concentrations of methylxanthines
  • doesn’t change drugs metabolism

Question 17

Question
Categories of ADRs are
Answer
  • certain
  • probable
  • possible
  • unlikely

Question 18

Question
Therapeutic drug monitoring is
Answer
  • method for neuroleptanalgesy
  • used, when there is relationship between plasma concentrations and drug effect
  • used for drugs with narrow therapeutic window
  • used for drugs with long half- live

Question 19

Question
Third phase of clinical trial can be determinated as
Answer
  • first application of a new substance to healthy volunteers
  • first application of a new substance to patients
  • efficacy and safety in a large number of patients
  • post-marketing surveillance in thou-sands of patients

Question 20

Question
Clearence is an index for
Answer
  • drugs excretion
  • determination of maintaining dose of the drugs
  • drugs absorption
  • effects of the drugs on the heart

Question 21

Question
Adverse drug reactions of methylxanthines are
Answer
  • arrhythmias
  • headache, fatigue, seizures
  • decreased diuresis
  • bradycardia

Question 22

Question
Bronchodilators are
Answer
  • Antimuscarinic drugs
  • β2-mimetics
  • Methylxanthines
  • H2-blockers

Question 23

Question
Drugs, used for treatment of chronic heart failure are
Answer
  • Cardiac glycosides
  • ACE- inhibitors
  • Calcium channel blockers
  • Diuretics

Question 24

Question
Diuretics, used in chronic liver failure are
Answer
  • osmotic diuretics
  • thiazide diuretics
  • loop diuretics
  • aldosterone antagonists

Question 25

Question
Anti-angina effect of β-blockers is due to
Answer
  • bradycardic effect
  • coronary vessels dilation
  • reduced oxygen demand of the heart
  • inhibition of platelet aggregation

Question 26

Question
Adverse drug reactions of dihydropyridine calcium channel antagonists are
Answer
  • tachycardia
  • bradycardia
  • swelling of ankles
  • flushing and headache

Question 27

Question
Withdrawal syndrome is observed in treatment with
Answer
  • Calcium channel blockers
  • β-blockers
  • Organic nitrates
  • Metabolotropic drugs

Question 28

Question
Drugs preferred for treatment of hypertensive crisis are
Answer
  • Furosemide
  • Clonidine
  • Nitroprusside
  • Pindolol

Question 29

Question
Which are the main drug groups for treatment of ulcer disease
Answer
  • antacids drugs
  • anti-secretion drugs
  • gastro-duodenal protectors
  • drugs against HP infections

Question 30

Question
Which are non-absorbent antacid drugs
Answer
  • sodium salts
  • calcium salts
  • aluminium salts
  • magnesium salts

Question 31

Question
Point out the correct statement for opioid analgesics
Answer
  • binds to specific opioid receptors
  • cause dependence and abuse
  • in high doses suppress the respiratory center
  • showed withdrawal in long term therapy

Question 32

Question
Which are the therapeutic effects of NSAIDs
Answer
  • analgesic
  • antipyretic
  • anti-inflammatory
  • cough suppressants

Question 33

Question
In patients with Gram (-) infections are preferred
Answer
  • Ureidopenicillins
  • Narrow spectrum penicillins
  • Macrolides
  • First generation cephalosporins

Question 34

Question
Antimicrobial drugs with renal excretion are
Answer
  • Penicillins
  • Quinolones
  • Macrolides
  • Aminoglycosides

Question 35

Question
Surrogates in rational pharmacotherapy are
Answer
  • clinical- laboratory indexes
  • instrumental investigations - ECG: EMG; MRT etc
  • disease improvement
  • decreased mortality rate

Question 36

Question
Pharmacodynamic changes in elderly are
Answer
  • increased sensitivity to drugs suppressing central nervous system
  • decreased sensitivity to drugs suppressing central nervous system
  • paradoxal reactions are observed
  • adverse drug reactions are more frequent

Question 37

Question
Steady-state plasma concentration is
Answer
  • blood concentration of the drug 2 hours after administration
  • blood concentration of the drug after repeated administration when there is a balance between absorbtion and excretion
  • blood concentration of the drug after it has been ceased
  • blood concentration of the drug during its absorbtion

Question 38

Question
Bad compliance of the patient may be due to
Answer
  • dose regimen with many drugs with frequent administration
  • a large number of drugs
  • lack of information for the treatment
  • the drug must be taken once daily

Question 39

Question
Fourth phase of clinical trial can be determinated as
Answer
  • first application of a new substance to healthy volunteers
  • first application of a new substance to patients
  • efficacy and safety in a large number of patients
  • post-marketing surveillance in thousands of patients

Question 40

Question
Drugs clearance is
Answer
  • amount of drug, that reaches systemic circulation
  • blood plasma volume from which the drug is eliminated for defined period of time
  • steady- state plasma concentration
  • withdrawal syndrome

Question 41

Question
β2-mimetics are contraindicated for patients with
Answer
  • diabetes
  • bradycardia
  • thyreotoxicosis
  • hypertension

Question 42

Question
Pethidine is indicated for
Answer
  • strong acute pain as some crisis
  • chronic pain in cancer patients
  • toothache
  • headache

Question 43

Question
The main mechanism of action of NSAIDs is
Answer
  • inhibition of COX enzymes
  • inhibition of phosphodiesterase
  • bind to dopamine receptors
  • bind to opioid receptors

Question 44

Question
The antibiotics of choice for patients with immune deficits are
Answer
  • bactericidal
  • bacteriostatic
  • carbapenemes
  • glycopeptides

Question 45

Question
Corticosteroids for systemic application are
Answer
  • Prednisone
  • Budesonide
  • Methylprednisolone
  • Prednisolone

Question 46

Question
The therapy of cardiac failure should starts
Answer
  • As earlier as having diagnose
  • ACE inhibitors are recommended as first line drugs
  • The very low doses are preferred
  • Start with high doses

Question 47

Question
The most often ADRs of β-blockers are
Answer
  • Tiredness
  • Bradycardia
  • AV block
  • Hypertension

Question 48

Question
For treatment of Prinzmetal angina are used
Answer
  • propranolol
  • diltiazem
  • verapamil
  • furosemide

Question 49

Question
Adverse drug reactions of ACE inhibitors are
Answer
  • angioedema
  • dry cough
  • hyperlipidemia
  • hyperglycemia

Question 50

Question
Mechanism of antihypertensive drugs are
Answer
  • decrease of blood volume
  • decreased sensitivity of vessels to vasoconstrictors
  • reduced activity of renin-angiotensin system
  • decreased peripheral vascular tone

Question 51

Question
Proton pump inhibitors are
Answer
  • Omeprazole
  • Rabeprazole
  • Mizoprostol
  • Lansoprazole

Question 52

Question
Gastrointestinal mucosa protectors are
Answer
  • Sucralphate
  • Misoprostol
  • Probiotics
  • Colloidal bismuths salts

Question 53

Question
Opioid analgesics are suitable for treatment of
Answer
  • traumatic shock
  • acute myocardial infarction
  • malignant pain
  • neuropathic pain

Question 54

Question
Which are the indications for prescribing NSAIDs
Answer
  • arthritis
  • toothache
  • radiculitis
  • neuropathic pain

Question 55

Question
Triptans are used for treatment of
Answer
  • acute migraine
  • prevention of migraine
  • cancer pain
  • allergies

Question 56

Question
Antimicrobial drugs for hepato-biliary infections are
Answer
  • Ceftriaxone (Rocephin)
  • Gentamycin
  • Rifampicin (Tubocin)
  • Doxyxyclin (Vibramycin)

Question 57

Question
Adverse drug reactions of aminoglycosides are
Answer
  • ototoxicity
  • nephrotoxicity
  • gastrointestinal problems
  • liver toxicity

Question 58

Question
Indications for using cardiac glycosides in the therapy of congestive heart failure are
Answer
  • early stage of chronic cardiac failure
  • heavy CCF
  • supra-ventricular fibrillations
  • decrease the mortality rate

Question 59

Question
Adverse drug reactions of non-dihyropyridine calcium channel antagonists are
Answer
  • tachycardia
  • bradycardia
  • constipation
  • heart failure

Question 60

Question
Anti-angina effects of organic nitrates is done by
Answer
  • decreased preload of the heart
  • improved oxygen supply
  • reduced afterload of the heart
  • dilation of coronary vessels

Question 61

Question
Typical for mixed type of insomnia are the following features
Answer
  • the difficulties to fall asleep
  • easy fall asleep
  • awakening during the night
  • early awake

Question 62

Question
Which of the following β2-mimetics are used as controllers
Answer
  • Salbutamol
  • Salmeterol
  • Seretide
  • Terbutaline

Question 63

Question
The quality of therapeutic decision (outcomes) can be measured by
Answer
  • clinical outcomes
  • costs — direct and indirect
  • functional status pf patient
  • overall patient satisfaction

Question 64

Question
Method of evaluation of cost/benefits ration are
Answer
  • cost minimization analysis
  • cost effectiveness analysis
  • cost utility analysis
  • cost consequence analysis

Question 65

Question
Diuretics are combined with which of the drugs for treatment of cardiac failure
Answer
  • ACE inhibitors
  • Cardiac glycosides
  • β-blockers
  • Organic nitrates

Question 66

Question
β2-mimetics should not be combined with
Answer
  • Corticosteroids
  • β-blockers
  • Leukotriene inhibitors
  • MAO inhibitors

Question 67

Question
Methylxanthines should not be combined with
Answer
  • Diuretics
  • β2-mimetics
  • Corticosteroids
  • Leukotriene antagonists

Question 68

Question
Characteristic feature of angiotensin receptor blockers (ARB) are
Answer
  • good tolerability
  • better compliance
  • complex hemodynamic improving effect
  • less tolerated and low compliance in comparison with ACE inhibitors

Question 69

Question
Antianginal drugs are
Answer
  • Cardiac glycosides
  • β-blockers
  • Organic nitrates
  • Calcium channel blockers

Question 70

Question
Antihypertensive drugs are
Answer
  • Diuretics
  • ACE inhibitors
  • Angiotensin receptor blockers
  • β-blockers

Question 71

Question
Adverse drug reactions of salt losing diuretics are
Answer
  • hyperglycemia
  • hyperuricemia
  • hypopotassiemia
  • hyperpotassiamia

Question 72

Question
Well known drug interactions of proton pump inhibitors are
Answer
  • decreased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin
  • decreased absorption of some drugs as digoxin, quinidine, theophylline, NSAIDs
  • increased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin
  • increased absorption of other drugs as digoxin, quinidine, theophylline, warfarin

Question 73

Question
Contraindicated during pregnancy or breast feedings drugs are
Answer
  • Bismuth salts
  • Misoprostol
  • Proton pump inhibitors
  • Antacid drugs

Question 74

Question
In which cases step-wise pain killing approach is used
Answer
  • patients with cancer pain
  • patients with crisis
  • patients with toothache
  • patients with headache

Question 75

Question
Which are the ADRs of NSAIDs the selective COX-2 inhibitors
Answer
  • cardio-toxicity
  • epidermal necrolysis
  • peptic ulcer
  • depressed fertility

Question 76

Question
Adverse drug reactions of triptans are
Answer
  • sleepiness
  • fatigue and dizziness
  • hyperglycemia
  • paresthesias

Question 77

Question
In patients with Gram (+) infections are preferred
Answer
  • Ureidopenicillins
  • Narrow spectrum penicillins
  • Macrolides
  • First generation cephalosporins

Question 78

Question
Adverse drug reactions of tetracyclines are
Answer
  • liver damage
  • ototoxicity
  • nephrotoxicity
  • teeth and bone damage

Question 79

Question
Adverse drug reactions of quinolones are
Answer
  • gastro-intestinal
  • damage of the joints
  • increase of intraocular pressure
  • provoke seizures in patients with epilepsy

Question 80

Question
Mechanisms of drug interactions are
Answer
  • unpredictable
  • pharmacokinetic
  • pharmacodynamic
  • pharmaceutical

Question 81

Question
Pharmacokinetic defects are
Answer
  • acetylation
  • oxidation
  • hydrolysis
  • red cells enzyme defects

Question 82

Question
Adverse drug reactions of β2-mimetics are
Answer
  • tachycardia
  • hyperglycemia
  • hypoglycemia
  • headache

Question 83

Question
For treatment of stable angina are preferred
Answer
  • Calcium channel blockers
  • Organic nitrates
  • Diuretics
  • β-blockers

Question 84

Question
Adverse drug reactions of nitrates used for acute attacks are
Answer
  • tachycardia
  • tolerance
  • hypertension
  • headache and flushing

Question 85

Question
Which are contraindications for NSAIDs non-selective COX inhibitors
Answer
  • asthma
  • peptic ulcer
  • liver insufficiency
  • kidney insufficiency

Question 86

Question
The benzodiazepines and some barbiturates exert the following ADRs
Answer
  • hypertension
  • drug tolerance and dependence
  • slowed reflex time and myorelaxation
  • morning sleepiness for the drugs which form active metabolites

Question 87

Question
Which of the following drugs are used to treat headache
Answer
  • Beta-blockers
  • Triptans
  • Opioid analgesics
  • NSAIDs

Question 88

Question
The rational drug combinations for treatment of headache are between the following drugs
Answer
  • NSAIDs and spasmolytics
  • NSAIDs and coffein
  • Opioid analgesics and NSAIDs
  • Analgesics and calcium channel antagonists

Question 89

Question
Quinolones are contraindicated for
Answer
  • pregnant women
  • breast feeding mothers
  • children under 12 years of age
  • patients with kidney failure

Question 90

Question
Adverse drug reactions of sulfonamides are
Answer
  • bone-marrow suppression
  • allergy
  • kidney damage in high doses
  • heart failure

Question 91

Question
Metabolic effects of glucocortcosteroids are
Answer
  • hypoglycemia
  • hyperglycemia
  • reduced calcium absorption
  • increased protein catabolism

Question 92

Question
Drugs decreasing myocardial hypertrophy are
Answer
  • β-blockers
  • Angiotensin receptors blockers
  • Diuretics
  • α-blockers

Question 93

Question
Rational drug combinations for treatment of hypertension are
Answer
  • β-blocker + α-blocker
  • β-blocker + diuretic
  • α-blocker + ACE inhibitor
  • Calcium channel antagonists + Diuretic

Question 94

Question
Adverse drug reactions of α1-blockers are
Answer
  • tachycardia
  • flush syndrome
  • dry mouth
  • orthostatic hypotension

Question 95

Question
Opioid analgesics are suitable for treatment of
Answer
  • traumatic shock
  • acute myocardial infarction
  • malignant pain
  • neuropathic pain

Question 96

Question
Which corticosteroids are used by inhalation in asthma attacks
Answer
  • Budesonide
  • Dexamethasone
  • Fluticasone
  • Beclomethasone

Question 97

Question
Antihypertensive drugs with direct vasodilating effects are
Answer
  • Diazoxide
  • Nitroprusside
  • Propranolol
  • Methyldopa

Question 98

Question
Antihypertensive drugs are
Answer
  • α2-agonists
  • α1-blockers
  • M-cholinolytics
  • Antihistamine drugs

Question 99

Question
Which are anti-secretion drugs
Answer
  • Proton pump inhibitors
  • H2-histamine blockers in stomach mucosa
  • M3-cholinergic blockers in stomach mucosa cells
  • COX inhibitors

Question 100

Question
Which drugs are used for eradication of Helicobacter pylori infections
Answer
  • proton pump inhibitors
  • colloidal bismuthi salts
  • histamine blockers
  • antibacterial drugs
Show full summary Hide full summary

Want to create your own Quizzes for free with GoConqr? Learn more.

Similar

Forensics Final MCQs- 5th Year PMU
Med Student
Infectious Diseases Test 1- 5th Year- PMU
Med Student
Infectious Diseases Test 2- 5th Year PMU
Med Student
Respiratory Disorders Clinical Pharmacology- 5th Year PMU
Med Student
Basic Principles of Clinical Pharmacology- 5th Year PMU
Med Student
Cardiovascular Diseases- Clinical Pharmacology 5th Year
Med Student
Cell Physiology and General Physiology of Excitable Tissues- Physiology PMU 2nd Year
Med Student
General Physiology of the Nervous System Physiology PMU 2nd Year
Med Student
Blood MCQs Physiology PMU 2nd Year
Med Student
General Pathoanatomy Final MCQs (111-200)- 3rd Year- PMU
Med Student
Muscles- Physiology MCQs PMU- 2nd Year
Med Student
Browse Library