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IBS Set 4 Quiz - Pharmacology
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Questions in this quiz (36)
1Parenteral administration of drugs describes what?
- AOrally/Rectally
- BIntravenously/Intramuscularly
- CInhaled
2Percutaneous administration of drugs describes what?
- AInhaled
- BOrally/Rectally
- CIntravenously/Intramuscularly
3Enteral administration of drugs describes what?
- AOrally/Rectally
- BIntravenously/Intramuscularly
- CInhaled
4What is an advantage of the parenteral route of administration?
- AEasy to administer on unconscious patients
- BReaches the blood stream first and avoids first pass metabolism
5What is an advantage of percutaneous administration of drugs?
- AEasy to administer on unconscious patients
- BReaches the blood stream first and avoids first pass metabolism
6Repeated doses of general anaesthetic such as thiopental can cause a fatal dose because of accumulation, or "tissue binding" in adipose tissue.
- ATrue
- BFalse
71st pass metabolism describes what phenomenon?
- AWhen the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly reduced because it is metabolised by the liver before it reaches the systemic circulation.
- BWhen the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly increased because it is metabolised by the liver before it reaches the systemic circulation.
81st pass metabolism can be useful for activating pre-cursor drugs such as L-dopa into dopamine.
- ATrue
- BFalse
9Steady state in pharmacology describes what?
- ADrug absorption = Drug elimination
- BDrug absorption > Drug elimination
- CDrug absorption < Drug elimination
10What is the plasma half life of a drug?
- AThe time for half of the drug to be eliminated from the blood
- BThe time it takes for a drug to lose half of its pharmacological activity
11What is meant by the hydrophobic effect?
- AAmino acids with non-polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
- BAmino acids with non-polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
- CAmino acids with polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
- DAmino acids with polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
12Haemoglobin in sickle cell is dysfunctional as a result of an incorrect hydrophobic effect.
- ATrue
- BFalse
13What is the primary structure of a protein?
- ASequence of amino acids
- BFolding into an alpha helix or beta pleated sheet
- CFolding of a polypeptide chain and addition of prosthetic groups
- DMany polypeptide chains
14What is the secondary structure of a protein?
- ASequence of amino acids
- BFolding into an alpha helix or beta pleated sheet
- CFolding of a polypeptide chain and addition of prosthetic groups
- DMany polypeptide chains
15What is the tertiary structure of a protein?
- ASequence of amino acids
- BFolding into an alpha helix or beta pleated sheet
- CFolding of a polypeptide chain and addition of prosthetic groups
- DMany polypeptide chains
16What is the quaternary structure of a protein?
- ASequence of amino acids
- BFolding into an alpha helix or beta pleated sheet
- CFolding of a polypeptide chain and addition of prosthetic groups
- DMany polypeptide chains
17The two weakly ionising groups of an amino acid are?
- AAmino group
- BCarboxyl group
- CR group
18With a pKa value of 9.7, and the equation NH3+ -> NH2 + H+ , at pH 9 what species will dominate?
- ANH2 + H+
- BNH3+
19What graph correctly depicts the dose response curve?
- A
- B
- C
- D
- A
20Response is proportional to occupancy
- ATrue
- BFalse
21The maximum response cannot be attained when a competitive reversible antagonist is present.
- ATrue
- BFalse
22In the presence of a competitive reversible antagonist, how is the dose response curve shifted?
- ALeft
- BRight
23An irreversible antagonist means that the maximum response can never be reached.
- ATrue
- BFalse
24How is the dose response curve shifted in the presence of an irreversible antagonist?
- ADown
- BUp
25Irreversible antagonists cause a decrease in the maximal response when spare receptors are not present.
- ATrue
- BFalse
26Prolonged exposure to a drug reduces the bodies response to it.
- ATrue
- BFalse
27Without spare receptors, non-competitive antagonists can reduce the maximal response (Emax).
- ATrue
- BFalse
28When a non-competitive antagonist is used in the presence of spare receptors, the dose response curve shifts left.
- ATrue
- BFalse
29Non-competitive antagonists do not compete for the agonist binding site.
- ATrue
- BFalse
30Irreversible antagonists reduce the number of available receptors.
- ATrue
- BFalse
31The dose response curve of an irreversible agonist is shifted down because the maximal response is decreased.
- ATrue
- BFalse
32Select common ways that cells regulate their functions via receptors
- AAltering membrane potential
- BPhosphorylating enzymes
- CAltered gene expression in cells
33An integral tyrosine kinase can be activated and then phosphorylates a target molecule such as an enzyme.
- ATrue
- BFalse
34Lipophobic molecules can cross the PM and NM and bind to steroid receptors e.g. to boost transcription.
- ATrue
- BFalse
35G-protein coupled receptors have ATPase activity that turns their activity off.
- ATrue
- BFalse
36Cytokine receptors activate JAK that can phosphorylate targets and lead to signal pathways.
- ATrue
- BFalse
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