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IBS Set 4 Quiz - Pharmacology

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Resource summary

Question 1

Question
Parenteral administration of drugs describes what?
Answer
  • Orally/Rectally
  • Intravenously/Intramuscularly
  • Inhaled

Question 2

Question
Percutaneous administration of drugs describes what?
Answer
  • Inhaled
  • Orally/Rectally
  • Intravenously/Intramuscularly

Question 3

Question
Enteral administration of drugs describes what?
Answer
  • Orally/Rectally
  • Intravenously/Intramuscularly
  • Inhaled

Question 4

Question
What is an advantage of the parenteral route of administration?
Answer
  • Easy to administer on unconscious patients
  • Reaches the blood stream first and avoids first pass metabolism

Question 5

Question
What is an advantage of percutaneous administration of drugs?
Answer
  • Easy to administer on unconscious patients
  • Reaches the blood stream first and avoids first pass metabolism

Question 6

Question
Repeated doses of general anaesthetic such as thiopental can cause a fatal dose because of accumulation, or "tissue binding" in adipose tissue.
Answer
  • True
  • False

Question 7

Question
1st pass metabolism describes what phenomenon?
Answer
  • When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly reduced because it is metabolised by the liver before it reaches the systemic circulation.
  • When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly increased because it is metabolised by the liver before it reaches the systemic circulation.

Question 8

Question
1st pass metabolism can be useful for activating pre-cursor drugs such as L-dopa into dopamine.
Answer
  • True
  • False

Question 9

Question
Steady state in pharmacology describes what?
Answer
  • Drug absorption = Drug elimination
  • Drug absorption > Drug elimination
  • Drug absorption < Drug elimination

Question 10

Question
What is the plasma half life of a drug?
Answer
  • The time for half of the drug to be eliminated from the blood
  • The time it takes for a drug to lose half of its pharmacological activity

Question 11

Question
What is meant by the hydrophobic effect?
Answer
  • Amino acids with non-polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with non-polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.

Question 12

Question
Haemoglobin in sickle cell is dysfunctional as a result of an incorrect hydrophobic effect.
Answer
  • True
  • False

Question 13

Question
What is the primary structure of a protein?
Answer
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Question 14

Question
What is the secondary structure of a protein?
Answer
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Question 15

Question
What is the tertiary structure of a protein?
Answer
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Question 16

Question
What is the quaternary structure of a protein?
Answer
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Question 17

Question
The two weakly ionising groups of an amino acid are?
Answer
  • Amino group
  • Carboxyl group
  • R group

Question 18

Question
With a pKa value of 9.7, and the equation NH3+ -> NH2 + H+ , at pH 9 what species will dominate?
Answer
  • NH2 + H+
  • NH3+

Question 19

Question
What graph correctly depicts the dose response curve?
Answer

Question 20

Question
Response is proportional to occupancy
Answer
  • True
  • False

Question 21

Question
The maximum response cannot be attained when a competitive reversible antagonist is present.
Answer
  • True
  • False

Question 22

Question
In the presence of a competitive reversible antagonist, how is the dose response curve shifted?
Image:
a652a37c-f89e-4d0e-9434-ddb8048c55c8 (image/png)
Answer
  • Left
  • Right

Question 23

Question
An irreversible antagonist means that the maximum response can never be reached.
Answer
  • True
  • False

Question 24

Question
How is the dose response curve shifted in the presence of an irreversible antagonist?
Image:
6bb22cbe-21da-4f09-9b52-8bf08c71fca6 (image/png)
Answer
  • Down
  • Up

Question 25

Question
Irreversible antagonists cause a decrease in the maximal response when spare receptors are not present.
Answer
  • True
  • False

Question 26

Question
Prolonged exposure to a drug reduces the bodies response to it.
Answer
  • True
  • False

Question 27

Question
Without spare receptors, non-competitive antagonists can reduce the maximal response (Emax).
Answer
  • True
  • False

Question 28

Question
When a non-competitive antagonist is used in the presence of spare receptors, the dose response curve shifts left.
Answer
  • True
  • False

Question 29

Question
Non-competitive antagonists do not compete for the agonist binding site.
Answer
  • True
  • False

Question 30

Question
Irreversible antagonists reduce the number of available receptors.
Answer
  • True
  • False

Question 31

Question
The dose response curve of an irreversible agonist is shifted down because the maximal response is decreased.
Answer
  • True
  • False

Question 32

Question
Select common ways that cells regulate their functions via receptors
Answer
  • Altering membrane potential
  • Phosphorylating enzymes
  • Altered gene expression in cells

Question 33

Question
An integral tyrosine kinase can be activated and then phosphorylates a target molecule such as an enzyme.
Answer
  • True
  • False

Question 34

Question
Lipophobic molecules can cross the PM and NM and bind to steroid receptors e.g. to boost transcription.
Answer
  • True
  • False

Question 35

Question
G-protein coupled receptors have ATPase activity that turns their activity off.
Answer
  • True
  • False

Question 36

Question
Cytokine receptors activate JAK that can phosphorylate targets and lead to signal pathways.
Answer
  • True
  • False
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