What is needed for the reaction of Phosphorylase B --> A to reverse itself?

Water (and a lack of inhibiting AMP)

Water (and a lack of inhibiting ATP)

Water (and a lack of inhibiting GMP)

Glycogen Phosphorylase

Question 1

Question

Which form of Glycogen Phosphorylase is relatively inactive?

Answer

Phosphorylase A
Phosphorylase B

Question 2

Question

In phosphorylase B, where is the N terminus?

Answer

Floating free in the cytoplasm
Attached to the protein body
Unattached from protein

Question 3

Question

Which of the forms of glyocgen phosphorylase is most effected by cellular AMP/ATP levels?

Answer

Phosphorylase A
Phosphorylase B

Question 4

Question

Which of the following phosphorylates Glycogen Phosphorylase?

Answer

Phosphorylase B Kinase
Phosphorylase A Kinase
Phosphorylase Kinase

Question 5

Question

What protein causes the dephosphorylation of phosphorylase?

Answer

Protein phosphatase
Protein phosphorylase
Prokein Kinase P

Question 6

Question

What is needed for the reaction of Phosphorylase B --> A to reverse itself?

Answer

Water (and a lack of inhibiting AMP)
Water (and a lack of inhibiting ATP)
Water (and a lack of inhibiting GMP)

Question 7

Question

What is different about Phosphorylase A to B?

Answer

Ser14 has been phosphorylated
Tyr14 has been phosphorylated
Thr14 has been phosphorylated

Question 8

Question

What difference does phosphorylating Glycogen phosphorylase make?

Answer

Makes the relaxed form much more likely
Makes the taut form much more likely
Deactivates it entirely

Question 9

Question

How does phosphorylase B Kinase connect Glycogen Phosphorylase levels to the level of stimulation?

Answer

It is activated by Ca2+- when the muscle is stimulated, glucose is needed and so glycogen is broken down
It is deactivated by Ca2+- when the muscle is stimulated, glucose is not needed and so glycogen isn't broken down

Question 10

Question

What part of Phosphorylase B Kinase binds to Calcium?

Answer

Calmodulin
Calsequestrin
Troponin C

Question 11

Question

Which parts of phosphorylase B kinase are regulatory?

Answer

Alpha and beta
Alpha and gamma
Gamma and beta

Question 12

Question

Which part of phosphorylase B kinase is catalytic?

Answer

Gamma
Delta
Beta

Question 13

Question

In phosphorylase B kinase's Ca2+ binding sites, what are the affinities?

Answer

2 high 2 low
4 high
4 low

Question 14

Question

What protein causes the phosphorylation of Phosphorylase B Kinase?

Answer

cAMP dependent Protein Kinase
Adenylate Cyclase
Glycogen Phosphorylase

Question 15

Question

What is another name of cAMP dependent protein kinase?

Answer

Protein Kinase A
Protein Kinase B
Protein Kinase C

Question 16

Question

What is the role of inhibitor one?

Answer

To bind to protein phosphatase, activating it
To bind to protein phosphatase, inhibiting it
To bind to protein kinase A, activating it

Question 17

Question

What is contained in the N terminus domain of Glycogen Phosphorylase?

Answer

The catalytic site
The allosteric effector site
The regulatory subunit

Question 18

Question

How does glycogen get from it's binding domain to the catalytic site?

Answer

A hydrophobic tunnel
A hydrophillic tunnel
A lipophobic tunnel

Question 19

Question

Why is glycogen phosphorylase's site in a deep groove?

Answer

To prevent AMP from entering
To prevent ATP from entering
To prevent water from entering

Question 20

Question

What happens if water enters the active site?

Answer

Nothing
The enzyme is deactivated
Hydrolysis occurs instead of phosphorolysis

Next up

Glycogen Phosphorylase

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Resource summary

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Question 12

Question 13

Question 14

Question 15

Question 16

Question 17

Question 18

Question 19

Question 20

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	Created by gina_evans0312 about 11 years ago