323663
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 11 years ago
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Question 1
Question
Which Gprotein causes the activation Phospholipase CBeta?
Answer
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Gq
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Gs
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Gi
Question 2
Question
How is Phospholipase CBeta activated?
Answer
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By GTP binding to the alpha subunit of the Gq protein
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By ATP binding to the alpha subunit of the Gq protein
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By GMP binding to the alpha subunit of the Gq protein
Question 3
Question
What is broken down by phospholipase CBeta?
Answer
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Phosphatidynositol 4,5 bisphophate
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Phosphatidynositol 3,5 bisphophate
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Phosphatidynositol 2,4 bisphophate
Question 4
Question
Which product of the PCbeta pathway causes the release of calcium from the ER?
Answer
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IP3
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Diacylglycerol
Question 5
Question
What role(s) does the released Ca perform?
Answer
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Activates protein kinase C
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Activates protein kinase B
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Activates various Ca dependent protein kinases
Question 6
Question
What residues are phosphorylated by the protein kinases activated by this pathway?
Answer
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Serine
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Threonine
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Tyrosine
Question 7
Question
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Answer
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PS
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C1A
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C4
Question 8
Question
What is the function of subunut C1A
Answer
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DAG binding site
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Calcium binding site
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Phosphatidyl serine binding site
Question 9
Question
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Answer
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Yes
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No
Question 10
Question
Which subunits are part of the catalytic domain?
Answer
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C1A
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C3
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C4
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PS
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C5
Question 11
Question
ATP binds to C2, True or False?
Answer
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True
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False
Question 12
Question
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Answer
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It moves to the membrane and binds with DAG
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It remains in the cytoplasm and binds with DAG
Question 13
Question
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Answer
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Phosphatidylserine
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Phosphatidylglycine
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Phosphatidylglutamate
Question 14
Question
Which of the following is a tumor promoting agent?
Answer
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Phorbol ester
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Orphol ester
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Phenyl ester
Question 15
Question
How do tumor promoting agents effect Phospholipase CBeta?
Answer
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They bind without being degraded, so it becomes hyperactive
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They stop the alpha subunit binding, so it becomes unreactive
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They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity
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