11115010
Beschreibung
Quiz von Michael Jardine, aktualisiert more than 1 year ago
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Erstellt von Michael Jardine
vor etwa 7 Jahre
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Frage 1
Frage
GnIH means what?
Antworten
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Gonadotropin Inducing Hormone
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Gonadotropin Inhibitory Hormone
Frage 2
Frage
Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?
Antworten
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Birds
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Mice
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Fish
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Salamanders
Frage 3
Frage
What does GnIH appear to be the “signaller” for in humans?
Antworten
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Stress-related suppression of reproduction
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Menopause
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Puberty
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Pregnancy-induced placentation changes
Frage 4
Frage
GnIH is also called:
Antworten
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RFamide-Related Peptide-3
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FRamide-Related Peptide-3
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RFamide-Related Peptide-1
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FRamide-Related Peptide-1
Frage 5
Frage
True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.
Antworten
- True
- False
Frage 6
Frage
GnIH is:
Antworten
-
Usually released into the portal system, but not in some animals (rats, mice).
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Released into the portal system, but only in some animals (rats, mice).
Frage 7
Frage
A major similarity between organisms is that GnIH is always localised in the:
Antworten
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Dorsomedial nucleus of the hypothalamus
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Dorsomedial nucleus of the hippocampus
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Dorsal horn of the hypothalamus
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Dorsal horn of the hippocampus
Frage 8
Frage
True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.
Antworten
- True
- False
Frage 9
Frage
True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.
Antworten
- True
- False
Frage 10
Frage
Advantages of using LAB AND DOMESTICATED animals as models include:
(select all that apply)
Antworten
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Well-adapted to labs
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Detailed knowledge of genetic background
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Transgenic manipulation allows specific focus
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Short generation time (longitudinal studies simple and comprehensive)
Frage 11
Frage
An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?
Antworten
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PTSD
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Alzheimer’s
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Cystic Fibrosis
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Developmental disorders
Frage 12
Frage
Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas:
(select all that apply)
Antworten
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Cortical
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Hippocampal
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Hypothalamic
Frage 13
Frage
The two main histopathological hallmarks of Alzheimer’s Disease (AD) are:
(select the two that apply)
Antworten
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Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases
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Intracellular Neurofibrillary Tangles (NFTs)
Frage 14
Frage
True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.
Antworten
- True
- False
Frage 15
Frage
Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons)
(select all that apply)
Antworten
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Wolverines
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Dolphins
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Polar Bears
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Tasmanian Tigers
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Tasmanian Devils
Frage 16
Frage
The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:
Antworten
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Degu (Octodon degus)
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Guinea pig (Cavia porcellus)
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Naked mole-rat (Heterocephalus glaber)
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Domestic dog (Canis familiaris)
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Fat-tailed dunnart (Sminthopsis crassicaudata)
Frage 17
Frage
What age do Degus start presenting Alzheimer’s symptoms?
Antworten
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~3-4 years
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~4-5 years
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~5-6 years
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~6-7 years
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