PHSI3011 10-2 Adipose in Metabolism

Beschreibung

PHSI3011 10-2 Adipose in Metabolism
Michael Jardine
Quiz von Michael Jardine, aktualisiert more than 1 year ago
Michael Jardine
Erstellt von Michael Jardine vor etwa 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Of the 5 cell types of adipose tissue, which are counted as the “stromal vascular fraction”?
Antworten
  • Adipocytes
  • Fibroblasts
  • Preadipocytes
  • Vascular endothelial cells
  • Immune cells (e.g. macrophages)

Frage 2

Frage
What proportion of the volume of adipose tissues is taken up by Adipocytes (as opposed to Fibroblasts, Preadipocytes, Vascular endothelial cells, Immune cells)?
Antworten
  • 20%
  • 40%
  • 60%
  • 80%

Frage 3

Frage
What is the effect of Insulin on each of the following things within Adipose tissue? Glucose uptake: [blank_start]__________[blank_end] Fatty Acid synthesis: [blank_start]__________[blank_end] Fatty Acid storage: [blank_start]__________[blank_end] Protein synthesis: [blank_start]__________[blank_end] Fatty Acid release: [blank_start]__________[blank_end]
Antworten
  • Stimulate
  • Inhibit
  • Stimulate
  • Inhibit
  • Stimulate
  • Inhibit
  • Stimulate
  • Inhibit
  • Stimulate
  • Inhibit

Frage 4

Frage
Adipocytes make triglycerides from which of the following:
Antworten
  • Glucose
  • Fatty Acids
  • Cholesterol

Frage 5

Frage
Adipocytes release adipokines like Leptin. Leptin is an example of which of the following:
Antworten
  • Lipids
  • Hormones
  • Peptides
  • Cytokines

Frage 6

Frage
Adipokines include which of the following:
Antworten
  • Lipids
  • Hormones
  • Peptides
  • Cytokines

Frage 7

Frage
Adipokines have been shows to influence which of the following:
Antworten
  • Metabolism
  • Food intake
  • Energy expenditure
  • Inflammation

Frage 8

Frage
True or false: Adipokines are secreted from adipocytes, but can also be secreted from other sites.
Antworten
  • True
  • False

Frage 9

Frage
Which gene is missing in the obese “OB” mouse?
Antworten
  • Leptin
  • Adiponectin
  • GLUT4

Frage 10

Frage
Leptin is released from the adipose tissue, then communicates with the [blank_start]__________[blank_end] to [blank_start]__________[blank_end]/[blank_start]__________[blank_end].
Antworten
  • Hypothalamus
  • Hippocampus
  • SUPPRESS energy intake
  • INCREASE energy intake
  • SUPPRESS energy expenditure
  • INCREASE energy expenditure

Frage 11

Frage
True or false: Most obese people are Leptin-deficient.
Antworten
  • True
  • False

Frage 12

Frage
Define Lipodystrophy:
Antworten
  • LACK of fat (in adipose tissue)
  • EXCESS of fat (in adipose tissue)
  • DISRUPTION of function of fat (in adipose tissue)
  • EXCESSIVE function of fat (in adipose tissue)

Frage 13

Frage
Leptin is a key hormone released from adipose tissue and is involved in [blank_start]__________[blank_end] metabolism in the WHOLE BODY.
Antworten
  • Glucose
  • Lipid
  • Neither
  • Both

Frage 14

Frage
True or false: Leptin therapy is a promising mode of treatment for most obese patients.
Antworten
  • True
  • False

Frage 15

Frage
True or false: Leptin therapy is a promising mode of treatment for patients with Type 1 Diabetes.
Antworten
  • True
  • False

Frage 16

Frage
True or false: Leptin therapy is a promising mode of treatment for patients with Type 2 Diabetes.
Antworten
  • True
  • False

Frage 17

Frage
The adipokine Adiponectin is one of the most highly secreted proteins in our blood. Its secretion is generally [blank_start]__________[blank_end] in obesity.
Antworten
  • Reduced
  • Increased
  • Unaffected

Frage 18

Frage
[blank_start]__________[blank_end] acts to stimulate AMP-kinase to increase β-oxidation [and] increase glucose uptake into the cell.
Antworten
  • Adiponectin
  • Leptin
  • Both of the above
  • Neither of the above

Frage 19

Frage
True or false: In addition to being stimulated by some adipokines, AMP-kinase is also regulated by exercise, to stimulate energy expenditure within a cell.
Antworten
  • True
  • False

Frage 20

Frage
Hypertrophy vs Hyperplasia (with a view on adipocytes) Hypertrophy = increase in [blank_start]__________[blank_end]; Hyperplasia = increase in [blank_start]__________[blank_end].
Antworten
  • Size
  • Number

Frage 21

Frage
True or false: Ectopic Lipid Accumulation is the “spill over” when adipocytes reach saturation and lipids start getting into other tissues (e.g. muscle, liver) where it causes metabolic dysfunction.
Antworten
  • True
  • False

Frage 22

Frage
True or false: Lipodystrophy is the “spill over” when adipocytes reach saturation and lipids start getting into other tissues (e.g. muscle, liver) where it causes metabolic dysfunction.
Antworten
  • True
  • False

Frage 23

Frage
Which of the two distributions are more strongly associated with metabolic disease? “Android” distribution – more around the upper body; “Gynoid” distribution – more around the lower body.
Antworten
  • Gynoid
  • Android

Frage 24

Frage
True or false: BMI = Body Mass Index; WHR = Waist-Hip Ratio
Antworten
  • True
  • False

Frage 25

Frage
Someone with a higher upper-body fat distribution will need to __________ in order to maintain homeostasis.
Antworten
  • Secrete MORE insulin
  • Secrete LESS insulin
  • Absorb MORE insulin
  • Absorb LESS insulin

Frage 26

Frage
True or false: Chronic inflammation often correlates with obesity because there’s increased migration of macrophages into the ADIPOSE tissue.
Antworten
  • True
  • False

Frage 27

Frage
Which of the following are associated with [adipose] hypertrophy and [adipose] hyperplasia?
Antworten
  • Hypoxia
  • Fibrosis
  • Inflammation
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