PHSI3011 11-2 Liver in Metabolic Homeostasis

Glycolysis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].

Glycogenesis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].

Gluconeogenesis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].

Glycogenolysis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].

The three rate-limiting steps of Gluconeogenesis are:

The three rate-limiting steps of Glycolysis are:

Which one is which: Glycolysis vs Gluconeogenesis

Put the three rate-limiting steps (of each side) in the right places.

Does insulin STIMULATE or SUPPRESS glucose disposal and glycogen&lipid synthesis?

Does insulin STIMULATE or SUPPRESS glucose production and VLDL secretion?

What’s a LIRKO?

What results in a LIRKO in regards to blood&serum glucose levels?

Loss of PTEN expression in the liver results in increased Liver Triglyceride levels. What’s PTEN?

Glucose is taken up in a GLUT2-dependent manner. It’s then stored as [blank_start]__________[blank_end] until blood glucose levels drop.

The liver contributes to the homeostasis of circulating levels of which?

The liver is the main clearance tissue for removal of Fatty Acids from circulation, then repackages them in what?

Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end] resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake

Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end]: TAG-rich VLDL interacts with VLDL-R, enters lysosomal pathway for hydrolysis and TAG synthesis.

Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end]: VLDL-remnants interact with a range of receptors for endocytosis.

Fatty Acid metabolism. The major pathways are: De novo lipogenesis: [blank_start]__________[blank_end] TriAcylGlycerol metabolism: [blank_start]__________[blank_end] β-Oxidation: [blank_start]__________[blank_end]

Fatty Acid Metabolism: loss of Lipolysis-Stimulated Receptor (LSR) expression does what?

Loss of CD36 in the liver leads to [blank_start]__________[blank_end] Plasma FA levels. Plasma FAs [blank_start]__________[blank_end] LPL activity. Therefore loss of CD36 [blank_start]__________[blank_end] Chylomicron/VLDL-TAG hydrolysis (breakdown). …Leading to [blank_start]__________[blank_end] of TAG in the circulation.

True or false: The Hepatokine ILGF stands for Insulin-Like Growth Factor.

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