PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

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PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)
Michael Jardine
Quiz von Michael Jardine, aktualisiert more than 1 year ago
Michael Jardine
Erstellt von Michael Jardine vor fast 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
[blank_start]__________[blank_end] serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the [blank_start]__________[blank_end] triggers release of PTH.
Antworten
  • Decreased
  • Increased
  • ParaThyroid Gland
  • Hypothalamus
  • Thyroid Gland

Frage 2

Frage
In response to decreased serum Calcium, PTH is released and goes to which of the following?
Antworten
  • Kidney
  • Bone
  • Gut
  • Muscle
  • Liver

Frage 3

Frage
In the kidney, what PTH has 3 effects. These are: a: [blank_start]_____[blank_end] 1,25 (OH)2 D; b: [blank_start]_____[blank_end] Ca reabsorption; c: [blank_start]_____[blank_end] PO4 reabsorption;
Antworten
  • Increase
  • Decrease
  • Increase
  • Decrease
  • Increase
  • Decrease

Frage 4

Frage
In the bone, PTH has 2 effects. These are: a: ↑ [blank_start]__________[blank_end]; b: ↑ Bone [blank_start]__________[blank_end] (releasing Ca).
Antworten
  • Osteoclasts
  • Osteoblasts
  • Osteocytes
  • Lining Cells
  • Resorption
  • Formation

Frage 5

Frage
PTH-1 is a class-B GPCR. Yeah?
Antworten
  • Yeah
  • Nah

Frage 6

Frage
The primary effect of Hyperparathyroidism is:
Antworten
  • Increase blood Ca
  • Decrease blood Ca
  • Increase kidney Ca
  • Decrease kidney Ca

Frage 7

Frage
PROLONGED increase of PTH results in which of the following:
Antworten
  • Increased osteoclasts
  • Decreased osteoclasts
  • Increased osteocytes
  • Decreased osteocytes
  • Increased bone resorption
  • Increased bone formation
  • Bone loss
  • Bone gain

Frage 8

Frage
The main effect of INTERMITTENT PTH is:
Antworten
  • Increased osteoblast numbers
  • Increased osteoclast numbers
  • Decreased osteoblast numbers
  • Decreased osteoclast numbers

Frage 9

Frage
True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.
Antworten
  • True
  • False

Frage 10

Frage
Sclerostin is a [blank_start]__________[blank_end] regulator of bone formation.
Antworten
  • Negative
  • Positive

Frage 11

Frage
Mutations that inactivate Sclerostin cause [blank_start]__________[blank_end] bone mass.
Antworten
  • Increased
  • Decreased

Frage 12

Frage
Sclerostin is produced by which of the following:
Antworten
  • Osteocytes
  • Osteoclasts
  • Osteoblasts
  • Lining Cells
  • PTH

Frage 13

Frage
Intermittent PTH [blank_start]__________[blank_end] sclerostin. Sclerostin [blank_start]__________[blank_end] Wnt signaling. Therefore Intermittent PTH has a [blank_start]__________[blank_end] effect on Wnt signalling and results in [blank_start]__________[blank_end] bone formation (and [blank_start]__________[blank_end] bone resorption).
Antworten
  • Decreases
  • Increases
  • Inhibits
  • Stimulates
  • Positive
  • Negative
  • Increased
  • Decreased
  • Decreased
  • Increased
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