Zusammenfassung der Ressource
Frage 1
Frage
Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process.
It composes [blank_start]__________[blank_end] of cell membranes.
Circulating cholesterol arises from the diet as well as from [blank_start]__________[blank_end] synthesis.
It circulates mostly as Cholesterol Ester (cholesterol + FA).
Antworten
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10%
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30%
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50%
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70%
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90%
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Intracellular
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Extracellular
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Intercellular
Frage 2
Frage
Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] levels. Caused by a loss of LDL-R.
Antworten
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Increased
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Decreased
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LDL-Chol
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HDL-Chol
Frage 3
Frage
Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] in the lysosome due to the loss of function of NPC1 and/or NPC2.
Antworten
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Free cholesterol
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FFA
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TAG
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Accumulation
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Dissipation
Frage 4
Frage
The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?
Frage 5
Frage
In cancer, metabolism changes.
De Novo Cholesterol [blank_start]__________[blank_end] [blank_start]__________[blank_end];
De Novo Lipid [blank_start]__________[blank_end] [blank_start]__________[blank_end].
Antworten
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Synthesis AND uptake
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Synthesis
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Uptake
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Increases
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Decreases
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Increases
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Decreases
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Synthesis AND uptake
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Synthesis
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Uptake
Frage 6
Frage
Prostate cancer growth is [primarily?] driven by [blank_start]__________[blank_end].
It’s a [blank_start]__________[blank_end] metabolism cancer and is greatly dependent on [blank_start]__________[blank_end].
Antworten
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Androgens
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Non-Warburg
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Warburg
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Fatty Acid oxidation
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Reactive Oxygen Species
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Cholesterol oxidation
Frage 7
Frage 8
Frage
Gene Expression of Steroidogenic Enzymes is [blank_start]__________[blank_end] in CRPC.