16366412
Beschreibung
Quiz von Berfin Miiau, aktualisiert more than 1 year ago
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Erstellt von Berfin Miiau
vor fast 6 Jahre
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Frage 1
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the main routes of enteral administration of drugs are
Antworten
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oral
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by injection
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rectal
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per mucosa
Frage 2
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Advantages of the oral route of drug administration are
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easily self-administered
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toxicity and overdose may be overcome with antidotes
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drugs avoid first-pass metabolism
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drugs go directly into the systemic circulation
Frage 3
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Advantages of the rectal route of drug administration are
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suitable for vomiting patients
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suitable for children
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suitable for unconscious patients
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a way to avoid first-pass metabolism
Frage 4
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Disadvantages of iv drug administration are
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a trained staff is required
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risk of bacterial contamination at the site of injection
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it is painful and stressful for the patient
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drugs undergo first-pass metabolism in the liver
Frage 5
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Point out the correct statements for iv drug administration
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aqueous solutions can be administered iv
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oil solutions can be administered iv
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has the highest bioavailability
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used for treatment of life-threatening conditions
Frage 6
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The subject of pharmacokinetics is
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drug absorption and distribution
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drug biotransformation
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drug elimination
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drug biological activity
Frage 7
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Point out the correct statements for passive diffusion
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does not require energy
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requires energy
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involves a carrier
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drugs move from high to lower concentration
Frage 8
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The diffusion of lipid soluble drugs
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depends on the charge of the drug molecule
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does not depend on the charge of the drug molecule
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is penetration through aqueous channels or pores
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is penetration through the biological membranes
Frage 9
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A drug-weak acid will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Frage 10
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A drug-weak base will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Frage 11
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Point out the correct statements for active drug transport
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it is energy- dependent
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it is not energy- dependent
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requires carriers
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does not require carriers
Frage 12
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Point out the correct statement for drugs bound to plasma proteins
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bound drugs are pharmacologically active
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only the unbound drugs can act on target sites in the tissues
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only the bound drugs are available to the process of elimination
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drugs may displace each other from the binding proteins
Frage 13
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Drug metabolism may
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increase a drug's pharmacological activity
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decrease a drug's pharmacological activity
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change the pharmacological effects of a drug
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change the toxicity of a drug
Frage 14
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first phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Frage 15
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Second phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Frage 16
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Phase I of drug metabolism
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may or may not involve cytochrome P450 system
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phase I reactions convert lipophilic molecules to more polar molcecules
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includes alcohol dehydrogenation, amine oxidation, hydrolysis
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consists of conjugation reactions
Frage 17
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Renal excretion of a drug will be reduced if
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the drug is a weak acid and the urine is alkaline
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the drug is a weak acid and the urine is acidic
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the drug is a weak base and the urine is alkaline
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the drug is a barbiturate and the urine is alkaline
Frage 18
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Drug pharmacodynamics includes
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drug effects
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mechanisms of drug action
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drug elimination
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how the organism changes drugs
Frage 19
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The changes that occur due to the interaction between drug molecules and organism structures are called
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drug effect
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drug action
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adverse drug reaction
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placebo effect
Frage 20
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The organism response as a result of the changes that have occured due to its interaction with the drug is called
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drug action
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drug effect
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adverse drug reaction
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placebo effect
Frage 21
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What is characteristic for a drug receptor
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induces (generates) a change in organism functions
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has selectivity
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has sensitivity
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has specifity
Frage 22
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Agonists are ligands which
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have affinity
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block receptors
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have intrinsic activity
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bind to the receptor
Frage 23
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Antagonists are ligands which
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have strong affinity
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have intrinsic activity
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block the receptor
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do not have intrinsic activity
Frage 24
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Therapeutic margin is the
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difference between maximal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between lethal and mean effective doses
Frage 25
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Drugs' therapeutic index is the
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difference between minimal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between mean lethal and mean effective doses
Frage 26
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Types of drug interaction are
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synergy
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antagonism
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synergy/ antagonism
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chemical antagonism (formation of complexes)
Frage 27
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Potentiation can be observed during the concomitant use of
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Fentanyl and Droperidol
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Heparin and Protamine
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Amoxicillin and Clavulonic acid
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Diazepam and Flumazenil
Frage 28
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Full competitive antagonist of opioid receptors, administered in acute opioid intoxication is
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Allylnormorphine
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Methadone
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Naloxone
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Flumazenil
Frage 29
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Chemical antagonism or complex formation can be observed in
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Morphine and Naloxone
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Diazepam and Flumazenil
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Epinephrine and Histamine
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Iron preparation and Deferroxamine
Frage 30
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Which of the following are enzyme inducers
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Phenytoin
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Phenobarbital
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Metamizol
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Metronidazole
Frage 31
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Multiple drug administration could lead to
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drug tolerance
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drug dependence
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drug accumulation
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allergic reactions
Frage 32
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Drug addicition/ dependence involves
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drug tolerance
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physical dependence
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psychological dependence
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allergy
Frage 33
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Antiseptics are used for
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decontamination of laundry and sanitary facilities
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decontamination of skin and mucous membranes
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internal administration
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treatment of fever
Frage 34
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Disinfectants are used for decontamination of
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urine, faeces and other
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mouth
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instruments
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clothing and underwear
Frage 35
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Antiseptics and disinfectants are
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detergents
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barbiturates
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oxidizing agents and halogen derivatives
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phenols
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