L38 Background T1DM

Beschreibung

PHCY310 Quiz am L38 Background T1DM, erstellt von Mer Scott am 14/05/2019.
Mer Scott
Quiz von Mer Scott, aktualisiert more than 1 year ago
Mer Scott
Erstellt von Mer Scott vor mehr als 5 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Tolerance is a state of immunological unresponsiveness, and an [blank_start]adaptive[blank_end] response of lymphocytes. It exists because lymphocytes have [blank_start]self-reactive[blank_end] receptor, as receptors are formed by somatic recombination and sometimes recognise [blank_start]self-tissue[blank_end]. They must be deleted, or controlled by tolerance.
Antworten
  • self-reactive
  • self-tissue
  • adaptive

Frage 2

Frage
Peripheral Tolerance is the mechanism for controlling self reactive cells that escaped deletion in their early stages. • 3 ways this may occur: 1. Ignorance; lymphocytes are [blank_start]physically[blank_end] separated from low conc. self-antigen at “immune privileged sites” eg the [blank_start]brain, eye, testes, foetus[blank_end]. The sites also produce [blank_start]immunosuppressive cytokines[blank_end]. 2. Anergy; antigen specific non-[blank_start]responsiveness[blank_end], a second signal needed from an [blank_start]APC[blank_end] is not there to activate [blank_start]T cell[blank_end]. 3. Suppression; an active process [blank_start]mediated[blank_end] by a suppressor or regulatory lymphocyte.
Antworten
  • physically
  • brain, eye, testes, foetus
  • immunosuppressive cytokines
  • responsiveness
  • APC
  • T cell
  • mediated

Frage 3

Frage
Autoimmunity is the breakdown of self tolerance.
Antworten
  • True
  • False

Frage 4

Frage
Diabetes is a T-cell mediated autoimmune disease.
Antworten
  • True
  • False
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