cGMP Stimulated Protein Kinase & NO Synthase

Beschreibung

Year 2 Quiz am cGMP Stimulated Protein Kinase & NO Synthase, erstellt von gina_evans0312 am 03/11/2013.
gina_evans0312
Quiz von gina_evans0312, aktualisiert more than 1 year ago
gina_evans0312
Erstellt von gina_evans0312 vor mehr als 10 Jahre
1423
0

Zusammenfassung der Ressource

Frage 1

Frage
What is so special about cGMPPK?
Antworten
  • It's anti-parallel
  • The subunits of the dimer can swap roles of damage occurs
  • It's only found in cardiac cells

Frage 2

Frage
How many cGMP bind per monomer?
Antworten
  • 2
  • 4
  • 6
  • 1
  • 3

Frage 3

Frage
Which order do the subunits go in (from N to C terminus) A= Dimerisation Domain B- Catalytic Domain C= Autoinhibitory Hinge Region D= cGMP binding sites 1 & 2
Antworten
  • A-C-D-B
  • A-B-D-C
  • C-A-D-B
  • C-D-A-B

Frage 4

Frage
What is the purpose of the autoinhibitory hinge region?
Antworten
  • Acts as a pseudosubstrate
  • Causes inhibition after a certain amount of activity

Frage 5

Frage
What motif does cGMP Stimulated Protein Kinase Phosphorylate?
Antworten
  • Arg-Ser-X-Arg
  • Arg-Thr-X-Arg
  • Arg-Arg-X-Ser
  • Arg-Arg-X-Thr

Frage 6

Frage
What is the role of this protein?
Antworten
  • The activation of cGMP dependent ion channels
  • Activates cGMP dependent phosphodiesterases
  • The activation of cGMP dependent proteins
  • Inhibits cGMP dependent phosphodiesterases

Frage 7

Frage
What is required for NO to be synthesized?
Antworten
  • NO synthase
  • FMD/FAD
  • O2
  • NADP
  • NADPH
  • FMD
  • Tetrahydrobiopterin

Frage 8

Frage
Which of the following stimulate NO production? A- AcH B- Bradylunin C- Nicotine D- Thrombin E- Cl- F- Ca2+
Antworten
  • A, B, D, F
  • A, D, E, F
  • B, C, D, F

Frage 9

Frage
Which system is NO part of?
Antworten
  • Paracrine
  • Juxtracrine
  • Autocrine
  • Endocrine

Frage 10

Frage
NO is synthase a monomer- True or False?
Antworten
  • True
  • False

Frage 11

Frage
How many types of NO synthase are there?
Antworten
  • Constitutive
  • Inducible
  • Constitutive & Inudcible

Frage 12

Frage
Why is NO produced by iNOS (Immune NO Synthase)
Antworten
  • It kills of pathogens
  • It's used to signal immune cells
  • It's used to bind and immobalise pathogens

Frage 13

Frage
NO Synthase produces a few mmol of NO over a minute- True or False?
Antworten
  • True
  • False- its pmol over a minute
  • False, it's micromol in a few seconds
  • False, its pmol over a few seconds

Frage 14

Frage
NO Synthase contains the following, but in which order? A-NADPH binding site B-Calmodulin Binding Site C-FMN centre D- FAD centre E-Haeme group F- Arg, O2 and Tetrahydropterin (Active site)
Antworten
  • E-F-B-C-D-A
  • A-D-B-C-F-E
  • E-F-A-C-D-B

Frage 15

Frage
Why are vascular endothelial cells equipped to cause vasodilation?
Antworten
  • It allows them to reduce blood pressure according to need
  • It allows them to increase blood flow to wounded areas
  • It prevents damage to veins under high pressure

Frage 16

Frage
Which neurotransmitter effects which cells? A- Ach B-Vasopressin
Antworten
  • Vascular Endothelial-A Skeletal Muscle-B
  • Vascular Endothelial- A&B Skeletal Muscle-A
  • Vascular Endothelial- A Skeletal Muscle-A&B

Frage 17

Frage
What is the role of nitroglycerin?
Antworten
  • An explosive
  • It liberates NO from tissues
  • Causes an increase in NO synthesis

Frage 18

Frage
What is the role of viagra?
Antworten
  • Inhibits phosphodiesterases
  • Prevents cGMP breakdown
  • Prolongs NO production
Zusammenfassung anzeigen Zusammenfassung ausblenden

ähnlicher Inhalt

Signalling and Receptor
Has Maj
Cell & Muscle Signalling
gina_evans0312
PIP2 Pathway
gina_evans0312
Calmodulin & Chatecholamines
gina_evans0312
Serpentine Receptors & Adrenaline
gina_evans0312
Alpha 1 Adrenergic Receptor Pathway
gina_evans0312
Guanylate Cyclase
gina_evans0312
RAS Activation
gina_evans0312
PKB Activation Through RAS
gina_evans0312
Soluble Guanylate Cyclase
gina_evans0312
Head, Neck and Back 2nd Sem- Anatomy 2nd Year- PMU
Med Student