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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage | Antworten |
When T.K is phosphorylated, which subunit of PI-3-Kinase binds first? | P85 |
What allows the regulatory subunit to bind? | The Sh2 domain |
Name the catalytic subunit of PI-3-Kinase | p110 |
When PI-3-Kinase is complete, what binds? | Activated RAS |
Role 1 of PI-3-Kinase | Phosphorylation if PIP2 to PIP3 |
Part of PDK1 that allows PIP3 interaction | Plectstrin homology domain |
Where does PDK1 activation occur? | The membrane |
What membrane molecule does PKB bind to? | Phosphatidynositol-3,4-bisphosphate |
Inactive PKB Structure | Has a pH domain and an activation lip hiding the kinase |
Part of PKB that binds to PIP2 | pH domain |
PKB binds to PIP2 | Causing partial activation |
Partial Activation caused by | PDK1 phosphorylating its activation lip |
Full activation caused by | PDK2 phosphorylating its C terminus |
PKB moves GLUT4 to membrane (T/F) | True |
PKB causes Glycogen breakdown (T/F) | False- it causes glycogen synthesis |
PKB increases protein synthesis (T/F) | True |
PKB phosphorylates Glycogen Synthase Kinase (T/F) | True- this prevents the deactivation of glycogen synthase |
PDK1 directly phosphorylates PKB (T/F) | True |
What allows the different proteins to bind to T.K? | The aa surrounding the tyrosine kinase |
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