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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage | Antworten |
Oncogene | Gene who's abnormal/mutated expression causes production of a malignant phenotype |
Proto-oncogene | Cellular homologue from which oncogene is derived |
Tumor Suppressor | Encodes a protein restricting cell growth |
Conversion to Oncogene - Deletion/Point mutation | Normal amounts of hyperactive proteins |
Conversion to Oncogene - Gene Fusion | Hyperactive fusion protein |
Conversion to Oncogene - Chromosome Rearrangement | Varies- Near a strong promoter, you get increased levels of normal protein |
Conversion to Oncogene - Gene Replication | Amplified levels of normal protein |
No of Oncogene Classifications (At G0/G1 border | 4 |
Competence Factors | Increases production of cell cycle regulators |
Example of a Progression Factor | EGF, PDGF, FGF |
Progression Factors | Must increase in conjunction with CF's, or the CF's are degraded and the cell remains in G0 |
Example of Progression Factors | Insulin or IGF1 |
Inhibitor Factors | Prevent accidental entering of mitotic cycle (must be absent for G1 to be entered) |
Example of Inhibitory Factors | TGFB |
Acutely Transforming Retroviruses | Viruses containing a viral oncogene |
No of Class of Tyrosine Kinase | 9- each has different signalling molecules |
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