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101756
Haemostasis
Description
bacalaureat Physiology Mind Map on Haemostasis, created by Caroline Oxford on 21/05/2013.
No tags specified
physiology
physiology
bacalaureat
Mind Map by
Caroline Oxford
, updated more than 1 year ago
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Created by
Caroline Oxford
over 11 years ago
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Resource summary
Haemostasis
1.) Vascular Spasm
Narrowing of blood vessel
2.) Platelet Plugging
Platelets (thrombocytes)
Platelets stem from Myeloid stem cells
Break off from Megakaryocytes (from Myeloid)
Blood-bourne, contain organelles and enzymes. No nuclear material
Stick to loose Collagen
Release ADP (adenosine diphosphate)
AND Thromboxane A2 (TxA2)
This increases stickiness
In undamaged vessels Prostacyclin inhibits
3.) Clotting/Coagulation
Intrinsic Pathway
Problems inside
Starts with Factor XII (Hageman Factor)
Activates to Factor XIIa
Cascades down to
Factor X Now needs Ca+ to activate X
Common Pathway
Factor Xa
Prothrombin
Enzyme Prothrombinase. Needs Ca+
Thrombin
Activates FVIII
Factor VIII Stabalises clot
Extrinsic Pathway
Outside tissue injury
Thromboplastin (Platelet Tissue Factor III)
Thromboplastin activates Factor XII
Released in very high concerntrations
Results in instant course to comman pathway
Factor X
Factor VIIa
Releases Thromboplastin
Plasma proteins (Factors) some made in liver with Vit K
Both pathways need Ca+ to activate
Fibrinogen made in Liver
Thrombin breaks down Fibrinogen
Fibrin Factor I
AND
Warfrin mimics Vit K (stops clotting factors)
Clot Removel
Plasminogen
Breaks down into Plasmin
Ptoteolytic Enzyme
Breaks down Fibrin
Called Fibinolysis
Plasma protein
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