601950
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
Pre-Proinsulin contains an R.E.R signal that moves it to the golgi
Answer
- True
- False
Question 2
Question
What is the role of the C-peptide part of the insulin chain
Answer
-
Formation of disulphide bonds between the alpha and beta chains
-
Formation of Fe-S bonds between the alpha and beta chains
-
Formation of peptide bonds between the alpha and beta chains
Question 3
Question
Pro-insulin is made of the alpha & beta chains and the c peptide
Answer
- True
- False
Question 4
Question
Which of the following cleave the c-peptide from the proinsulin?
Answer
-
Endopeptidase
-
Enteropeptidase
-
Carboxypeptidase
Question 5
Question
What form does newly made insulin take?
Answer
-
Granules
-
Crystals
-
Rods
Question 6
Question
The cleaved C-peptide is released along with the insulin
Answer
- True
- False
Question 7
Question
Why do Mannoheptulases inhibit insulin release?
Answer
-
The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit
-
MHLs block excretory channels
-
MHLs prevent the movement of insulin to the RER
Question 8
Question
Optimum insulin secretion occurs at 8mM
Answer
- True
- False
Question 9
Question
Why is optimal secretion of insulin at 8mM
Answer
-
GLUT 2 & glucokinase have Kms of 8
-
Not gonna put anything else
-
Because reasons
Question 10
Question
Insulin secretion relies on ATP dependent K+ channels
Answer
- True
- False
Question 11
Question
K+ buildup causes Ca2+ influx and insulin secretion
Answer
- True
- False
Question 12
Question
Which drugs block K+ channels and mimic high glucose?
Answer
-
Sulpynoylurea
-
Sulphinomides
-
Sulphinomics
Question 13
Question
Diazoxide causes insulin secretion by keeping channels open
Answer
- True
- False
Question 14
Question
High doses of adrenaline stimulates insulin secretion through _ receptors
Answer
-
Alpha 1
-
Alpha 2
-
Beta 1
-
Beta 2
Question 15
Question
Low concs of adrenaline inhibit insulin secretion through Beta receptors
Answer
- True
- False
Question 16
Question
Insulin is catabolic
Answer
- True
- False
Question 17
Question
Insulin stimulates _ activity in order to reduce cAMP levels
Answer
-
Phosphodiesterases
-
Adenylate cyclase
Question 18
Question
Which of the following metabolites are reduced?
Answer
-
Fatty Acyl CoA
-
Acetyl CoA
-
Malonyl CoA
-
Palmitite
Question 19
Question
Inc. Phosphorylation of tyrosine kinase by insulin causes what?
Answer
-
Inc tyrosine kinase activity
-
Inc phosphatase activity
-
Inc Adenylate cyclase activity
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