11115010
Descripción
Test por Michael Jardine, actualizado hace más de 1 año
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Creado por Michael Jardine
hace alrededor de 7 años
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Pregunta 1
Pregunta
GnIH means what?
Respuesta
-
Gonadotropin Inducing Hormone
-
Gonadotropin Inhibitory Hormone
Pregunta 2
Pregunta
Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?
Respuesta
-
Birds
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Mice
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Fish
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Salamanders
Pregunta 3
Pregunta
What does GnIH appear to be the “signaller” for in humans?
Respuesta
-
Stress-related suppression of reproduction
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Menopause
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Puberty
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Pregnancy-induced placentation changes
Pregunta 4
Pregunta
GnIH is also called:
Respuesta
-
RFamide-Related Peptide-3
-
FRamide-Related Peptide-3
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RFamide-Related Peptide-1
-
FRamide-Related Peptide-1
Pregunta 5
Pregunta
True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.
Respuesta
- True
- False
Pregunta 6
Pregunta
GnIH is:
Respuesta
-
Usually released into the portal system, but not in some animals (rats, mice).
-
Released into the portal system, but only in some animals (rats, mice).
Pregunta 7
Pregunta
A major similarity between organisms is that GnIH is always localised in the:
Respuesta
-
Dorsomedial nucleus of the hypothalamus
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Dorsomedial nucleus of the hippocampus
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Dorsal horn of the hypothalamus
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Dorsal horn of the hippocampus
Pregunta 8
Pregunta
True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.
Respuesta
- True
- False
Pregunta 9
Pregunta
True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.
Respuesta
- True
- False
Pregunta 10
Pregunta
Advantages of using LAB AND DOMESTICATED animals as models include:
(select all that apply)
Respuesta
-
Well-adapted to labs
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Detailed knowledge of genetic background
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Transgenic manipulation allows specific focus
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Short generation time (longitudinal studies simple and comprehensive)
Pregunta 11
Pregunta
An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?
Respuesta
-
PTSD
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Alzheimer’s
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Cystic Fibrosis
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Developmental disorders
Pregunta 12
Pregunta
Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas:
(select all that apply)
Respuesta
-
Cortical
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Hippocampal
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Hypothalamic
Pregunta 13
Pregunta
The two main histopathological hallmarks of Alzheimer’s Disease (AD) are:
(select the two that apply)
Respuesta
-
Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases
-
Intracellular Neurofibrillary Tangles (NFTs)
Pregunta 14
Pregunta
True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.
Respuesta
- True
- False
Pregunta 15
Pregunta
Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons)
(select all that apply)
Respuesta
-
Wolverines
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Dolphins
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Polar Bears
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Tasmanian Tigers
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Tasmanian Devils
Pregunta 16
Pregunta
The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:
Respuesta
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Degu (Octodon degus)
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Guinea pig (Cavia porcellus)
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Naked mole-rat (Heterocephalus glaber)
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Domestic dog (Canis familiaris)
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Fat-tailed dunnart (Sminthopsis crassicaudata)
Pregunta 17
Pregunta
What age do Degus start presenting Alzheimer’s symptoms?
Respuesta
-
~3-4 years
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~4-5 years
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~5-6 years
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~6-7 years
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