PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

Descripción

PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)
Michael Jardine
Test por Michael Jardine, actualizado hace más de 1 año
Michael Jardine
Creado por Michael Jardine hace alrededor de 7 años
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Resumen del Recurso

Pregunta 1

Pregunta
[blank_start]__________[blank_end] serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the [blank_start]__________[blank_end] triggers release of PTH.
Respuesta
  • Decreased
  • Increased
  • ParaThyroid Gland
  • Hypothalamus
  • Thyroid Gland

Pregunta 2

Pregunta
In response to decreased serum Calcium, PTH is released and goes to which of the following?
Respuesta
  • Kidney
  • Bone
  • Gut
  • Muscle
  • Liver

Pregunta 3

Pregunta
In the kidney, what PTH has 3 effects. These are: a: [blank_start]_____[blank_end] 1,25 (OH)2 D; b: [blank_start]_____[blank_end] Ca reabsorption; c: [blank_start]_____[blank_end] PO4 reabsorption;
Respuesta
  • Increase
  • Decrease
  • Increase
  • Decrease
  • Increase
  • Decrease

Pregunta 4

Pregunta
In the bone, PTH has 2 effects. These are: a: ↑ [blank_start]__________[blank_end]; b: ↑ Bone [blank_start]__________[blank_end] (releasing Ca).
Respuesta
  • Osteoclasts
  • Osteoblasts
  • Osteocytes
  • Lining Cells
  • Resorption
  • Formation

Pregunta 5

Pregunta
PTH-1 is a class-B GPCR. Yeah?
Respuesta
  • Yeah
  • Nah

Pregunta 6

Pregunta
The primary effect of Hyperparathyroidism is:
Respuesta
  • Increase blood Ca
  • Decrease blood Ca
  • Increase kidney Ca
  • Decrease kidney Ca

Pregunta 7

Pregunta
PROLONGED increase of PTH results in which of the following:
Respuesta
  • Increased osteoclasts
  • Decreased osteoclasts
  • Increased osteocytes
  • Decreased osteocytes
  • Increased bone resorption
  • Increased bone formation
  • Bone loss
  • Bone gain

Pregunta 8

Pregunta
The main effect of INTERMITTENT PTH is:
Respuesta
  • Increased osteoblast numbers
  • Increased osteoclast numbers
  • Decreased osteoblast numbers
  • Decreased osteoclast numbers

Pregunta 9

Pregunta
True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.
Respuesta
  • True
  • False

Pregunta 10

Pregunta
Sclerostin is a [blank_start]__________[blank_end] regulator of bone formation.
Respuesta
  • Negative
  • Positive

Pregunta 11

Pregunta
Mutations that inactivate Sclerostin cause [blank_start]__________[blank_end] bone mass.
Respuesta
  • Increased
  • Decreased

Pregunta 12

Pregunta
Sclerostin is produced by which of the following:
Respuesta
  • Osteocytes
  • Osteoclasts
  • Osteoblasts
  • Lining Cells
  • PTH

Pregunta 13

Pregunta
Intermittent PTH [blank_start]__________[blank_end] sclerostin. Sclerostin [blank_start]__________[blank_end] Wnt signaling. Therefore Intermittent PTH has a [blank_start]__________[blank_end] effect on Wnt signalling and results in [blank_start]__________[blank_end] bone formation (and [blank_start]__________[blank_end] bone resorption).
Respuesta
  • Decreases
  • Increases
  • Inhibits
  • Stimulates
  • Positive
  • Negative
  • Increased
  • Decreased
  • Decreased
  • Increased
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