Pregunta 1
Pregunta
EGF-(R) = [blank_start]Epidermal Growth Factor[blank_end] (Receptor)
ER = [blank_start]Estrogen Receptor[blank_end]
HER = [blank_start]Human Epidermal Receptor[blank_end]
HPV = [blank_start]Human PapillomaVirus[blank_end]
PR = [blank_start]Progesterone Receptor[blank_end]
VEGF (R) = [blank_start]Vascular Epidermal Growth Factor[blank_end] (Receptor)
TKI = [blank_start]Tyrosine kinase Inhibitor[blank_end]
ALK = [blank_start]Anaplastic lymphoma kinase[blank_end]
CRC = [blank_start]Colorectal carcinoma[blank_end]
MCA = [blank_start]Monoclonal antibody[blank_end]
Respuesta
-
Estrogen Receptor
-
Human Epidermal Receptor
-
Human PapillomaVirus
-
Progesterone Receptor
-
Vascular Epidermal Growth Factor
-
Epidermal Growth Factor
-
Tyrosine kinase Inhibitor
-
Anaplastic lymphoma kinase
-
Colorectal carcinoma
-
Monoclonal antibody
Pregunta 2
Pregunta
According to WHO data by 2030, malignancies will be the leading cause of mortality. What place do they occupy now?
Respuesta
-
third
-
fourth
-
second
-
first
Pregunta 3
Pregunta
Which are the most often occurring tumors in children up to 10 years of age?
Respuesta
-
neuroblastoma, leukemias, gastrointestinal tumors
-
acute leukemias, brain tumors, Wilms tumor
-
retinoblastoma, nephroblastoma, gastrointestinal tumors
-
lymphomas, leukemias, brain tumors
Pregunta 4
Pregunta
What are the most common neoplasias in the 2nd and 3rd decades of life?
Respuesta
-
soft tissue tumors, testicular carcinoma
-
mesenchymal tumors, breast cancer
-
gastrointestinal tumors, osteosarcoma
-
lung cancer, head and neck tumors
Pregunta 5
Pregunta
What are the most common neoplasias in the 3rd and 4th decades of life?
Respuesta
-
female genital tract tumors, male genital tract tumors
-
breast cancer, uterine cancer, CRC
-
lung cancer, breast cancer, CNS tumors
-
head and neck tumors, sarcomas
Pregunta 6
Pregunta
What are the most common neoplasias after the 5th decade of life?
Respuesta
-
Lung carcinoma, prostate gland carcinoma
-
Tumors of GIT, bladder carcinoma
-
CRC, prostate and lung carcinoma
-
Head and neck tumors, lung cancer
Pregunta 7
Pregunta
There are differences In cancer morbidity and mortality between males and females. What is the gender predominance of CRC and stomach cancer?
Pregunta 8
Pregunta
Depending on geographic latitudes there is differential endemic Spread of neoplasms. Gastric carcinoma occurs predominantly in:
Respuesta
-
USA, Europe, Japan
-
Asia, Europe
-
Latin America, Eastern Europe, Japan
-
Southeast Asia and Africa
Pregunta 9
Pregunta
CRC occurs with the highest frequency in:
Pregunta 10
Pregunta
Mammary carcinoma is rare in:
Pregunta 11
Pregunta
The Epstein-Barr virus is associated with infectious mononucleosis nasopharyngeal carcinoma, and Burkitt's lymphoma. The latter has marked endemic spread:
Respuesta
-
The Scandinavian countries, Mongolia
-
Malaysia, Uganda, New Guinea
-
Japan, the Philippines
-
Australia and New Zealand
Pregunta 12
Pregunta
What is screening?
Respuesta
-
testing a group of people for the detection of early-stage cancers
-
examining a group of people when certain symptoms and complaints are present
-
detection of unplanned disease by tests and procedures that can be applied quickly
-
evidence of disease’s initial symptoms
Pregunta 13
Pregunta
What types of cancer screenings are available?
Respuesta
-
Lung carcinoma, colon carcinoma, breast cancer
-
CRC, prostate, stomach
-
Breast cancer, prostate, cervical carcinoma
-
CRC, breast cancer, lung carcinoma
Pregunta 14
Pregunta
Which of the following cancers affect predominantly men
Respuesta
-
lung, prostate, colorectal carcinoma
-
melanoma, pancreas, lung
-
colon, prostate, melanoma
-
lung, pancreas, brain
Pregunta 15
Pregunta
Which tumors in women confer the lowest five-year survival rate?
Respuesta
-
breast
-
ovary
-
corpus uteri
-
lung
Pregunta 16
Pregunta
Areas with the highest oncological morbidity at present are
Respuesta
-
Americas
-
Europe
-
Africa
-
Europe and Americas
Pregunta 17
Pregunta
Which tumors in males confer the lowest five-year survival rate?
Respuesta
-
testicular carcinoma
-
lung cancer
-
prostate cancer
-
colon cancer
Pregunta 18
Pregunta
The most common Malignant tumor in Women is
Respuesta
-
Mammary Carcinoma
-
Cervical Carcinoma
-
Skin carcinoma
-
Ovarian Carcinoma
Pregunta 19
Pregunta
What is the most accurate definition of carcinogenesis?
Respuesta
-
The occurrence of mutations in more than one locus leading to the appearance of a transformed cell
-
Multistage and prolonged process leading to transformed cells with subsequent clonal selection and expansion
-
Multistage process of transformation and development of neoplastic clone
-
There is no correct answer
Pregunta 20
Pregunta
Tumorigenesis occurs in three stages
Respuesta
-
Proliferation, promotion, metastasis
-
Initiation, promotion, proliferation
-
Proliferation, promotion, progression
-
All answers are correct
Pregunta 21
Respuesta
-
the ability of cancer cells to metastasize via the blood and to form new vessels
-
uncontrolled growth of tissue that can deliver distant metastasize via the blood and the lymphatics
-
uncontrolled development of tissue with the ability to grow and metastasize by forming new vessels
-
there is no correct answer
Pregunta 22
Pregunta
Key features of the tumor cell are
Respuesta
-
ability to proliferate, metastasize, form new vessels and the possibility of apoptosis, invasion
-
loss of apoptosis, endless division, invasion and metastasis
-
generates signals for growth and development, ability to form new vessels and metastasize via the blood
-
all answers are correct
Pregunta 23
Pregunta
What is the definition of benign tumors?
Respuesta
-
varying degrees of cellular and structural differentiation, do not metastasize
-
highly differentiated tumors whose cells resemble those from which they originated
-
a high degree of cell differentiation, the presence of functional activity and metastatic ability
-
answers a+c
Pregunta 24
Pregunta
Which statement about malignant tumors is wrong?
Respuesta
-
varying degrees of cell differentiation and structural organization
-
cells are organized in monolayers with signs of anaplasia
-
have an infiltrative growth
-
there is no correct answer
Pregunta 25
Pregunta
What is relapse?
Respuesta
-
a newly emerging tumor
-
the reappearance of a tumor following its surgical removal
-
the appearance of a tumor at the same site as the one removed
-
the appearance of regional lymph nodes
Pregunta 26
Pregunta
Malignant tumors have infiltrative growth, cellular atypism, are encapsulated capsule and have the ability to give regional and distant metastases.
This statement is
Respuesta
-
true
-
untrue
-
incomplete
-
ambiguous
Pregunta 27
Pregunta
Mesenchymal tumors metastasize
Respuesta
-
Via lymphatics
-
Via blood
-
Canalicularly
-
Intracavitary
Pregunta 28
Pregunta
The tumors of __________ metastasize in Intravascular fashion
Pregunta 29
Pregunta
Which of the following statements are characteristic of the cancer cell biology
Pregunta 30
Pregunta
Indicate which factors are associated with tumor progression
Pregunta 31
Pregunta
Paraneoplastic syndrome is due to
Pregunta 32
Pregunta
Which tumors are hormone-dependent in their development
Respuesta
-
breast carcinoma
-
colon carcinoma
-
endometrial carcinoma
-
all listed
Pregunta 33
Pregunta
Genetic changes leading to carcinogenesis are
Pregunta 34
Pregunta
Characteristics of neoplastic cells are
Pregunta 35
Pregunta
The most common primary brain tumors are
Respuesta
-
anaplastic astrocytomas
-
glioblastomas
-
oligodendrogliomas
-
there is no true answer
Pregunta 36
Pregunta
The mean survival rate for malignant CNS tumors is
Respuesta
-
5-10 months
-
15-18 months
-
2 years
-
One year
Pregunta 37
Pregunta
A radical method for the treatment of solitary («3 cm) CNS tumors is
Pregunta 38
Pregunta
Radiation is an important part of the complex treatment.
The total dose of craniotherapy is
Respuesta
-
40 Gy
-
60 Gy
-
80 Gy
-
There is no true answer
Pregunta 39
Pregunta
Chemotherapy incorporates
Respuesta
-
Cisplatin
-
Gemcitabine
-
Temozolamide
-
There is no true answer
Pregunta 40
Pregunta
Medulloblastoma is predominantly located in the rear cranial well and occurs most commonly in
Pregunta 41
Pregunta
The main methods of diagnosis and follow-up of treatment effect in CNS tumors are
Respuesta
-
CT and MRI
-
MRI and PET scan
-
CT and PET scan
-
All answers are correct
Pregunta 42
Pregunta
Symptomatic therapy in CNS tumors includes
Respuesta
-
dexamethasone, tranquilizers, diuretics
-
anxiolytics, diuretics
-
anticonvulsants, diuretics, dexamethasone
-
all answers are correct
Pregunta 43
Pregunta
Brain metastases are yielded most commonly by
Respuesta
-
Prostate and lung carcinoma
-
Thyroid and gastric carcinoma
-
Carcinoma of the mammary gland and lung carcinoma
-
Kidney and GIT carcinoma
Pregunta 44
Pregunta
Which treatment method will be preferred for solitary brain metastasis
Pregunta 45
Pregunta
Temozolamide used to treat brain tumors belongs to which group of cytostatics based on its mechanism of action
Pregunta 46
Pregunta
Methods for the treatment of multiple brain metastases are
Respuesta
-
surgery
-
radiotherapy
-
chemotherapy
-
b+c
Pregunta 47
Pregunta
List the symptoms of increased intracranial pressure
[blank_start]Altered[blank_end] behaviour
[blank_start]Blurred vision[blank_end]
Feeling less alert than usual
[blank_start]Headache[blank_end]
Lack of energy or sleepiness
[blank_start]Vomiting[blank_end]
Weakness or problems with moving or talking
Respuesta
-
Altered
-
Blurred vision
-
Headache
-
Vomiting
Pregunta 48
Pregunta
Risk factors for head and neck tumors are
Respuesta
-
chronic etilism, 3rd and 4th decade of life, male Sex, tobacco chewing
-
smoking, systemic use of alcohol and mutation in p53 gene
-
female sex, smoking, alcohol abuse
-
all answers are correct
Pregunta 49
Pregunta
The most common head and neck tumors metastasize
Pregunta 50
Pregunta
Head and neck tumors occur with the highest frequency at which anatomic sites
Respuesta
-
The oral cavity
-
Oropharynx
-
Larynx
-
Sinus
Pregunta 51
Pregunta
The characteristic clinical picture includes
Respuesta
-
pain, fever, soore, difficulty swallowing
-
ulcer. dysphagia, otalgia
-
dysphagia, dyspnoea, swelling in the neck, soor
-
all answers are correct
Pregunta 52
Pregunta
The most common histology of head and neck tumors is
Respuesta
-
adenocarcinomas
-
epidermoid carcinomas
-
squamous cell carcinomas
-
there is no true answer
Pregunta 53
Pregunta
A leading treatment approach for head and neck tumors is
Respuesta
-
radiotherapy
-
chemotherapy
-
chemoradiotherapy
-
all answers are correct
Pregunta 54
Pregunta
The most common early radiation reactions are
Pregunta 55
Pregunta
Late radiation complications are
Pregunta 56
Pregunta
The gold standard for nasopharyngeal carcinoma is
Respuesta
-
surgery, radiation, chemotherapy
-
operative intervention and subsequent radiotherapy
-
combined chemoradiotherapy
-
all the options listed
Pregunta 57
Pregunta
Targeted therapy for head and neck tumors is performed with
Respuesta
-
Bevacizumab
-
Cetuximab
-
Panitumumab
-
Nivolumab
Pregunta 58
Pregunta
HPV is related to the etiology of
Respuesta
-
cervical carcinoma
-
anogenital carcinoma
-
head and neck carcinoma
-
all listed
Pregunta 59
Pregunta
Head and neck tumors include neoplasia originating from anatomical locations
Respuesta
-
salivary glands, larynx, pharynx, oral cavity, nasal cavity, maxillary, frontal, ethmoidal, sphenoidal sinus
-
larynx, pharynx, oral and nasal cavities, parotid gland
-
parotid gland, larynx, pharynx, oral cavity, nasal cavity, paranasal sinuses
-
parotid gland, larynx, pharynx, oral cavity, nasal cavity, maxillary, frontal, ethmoidal sinus
Pregunta 60
Pregunta
Tumors of head and neck are characterized by
Respuesta
-
increased frequency in Central Asia
-
mainly affect female subjects
-
most common in the western world
-
a+b
Pregunta 61
Pregunta
Complete the term against the relevant definition of premalignant lesions that are associated with the development of squamous cell carcinoma:
[blank_start]Leucoplakia[blank_end] - hyperkeratosis + underlying epithelial hyperplasia
[blank_start]Erythroplakia[blank_end] - superficial erythema spots near to normal mucosa due to epithelial dysplasia
Respuesta
-
Leucoplakia
-
Erythroplakia
Pregunta 62
Pregunta
The therapeutic approach to advanced disease includes
Respuesta
-
protocols with combined modality (radiochemotherapy)
-
radical surgery
-
administration of platinum-based chemotherapy protocol
-
the combined use of surgery radiotherapy
Pregunta 63
Pregunta
The four major histological types of lung carcinoma are
Respuesta
-
large cell, squamous, papillary, small cell
-
small cell, squamous cell, adenocarcinoma, large cell
-
spinocellular, acinar, small cell, large cell
-
there is no correct answer
Pregunta 64
Pregunta
Which histological type has the worst prognosis?
Respuesta
-
spinocellular
-
acinar adenocarcinoma
-
small cell
-
there is no true answer
Pregunta 65
Pregunta
What are the principal biomarkers for NSCLC?
Respuesta
-
EGFR, HER-2
-
K-RAS, HER-2
-
ALK, PDL-1
-
EGFR, ALK, PDL-1
Pregunta 66
Pregunta
The standard for ChTh in radically operated patients with NSCLC is
Respuesta
-
APCT containing taxane
-
APCT containing cisplatin
-
APCT containing vinorelbine
-
APCT containing anthracyclines
Pregunta 67
Pregunta
Target therapies for NSCLC include
Respuesta
-
Bevacizumab, Panitumumab, Nivolumab
-
Erlotinib, Gefitinib, Crizotinid
-
Pertuzumab, Cetuximab, Pembrolizumab
-
There is no true answer
Pregunta 68
Pregunta
Malignant Mesothelioma is characterized by (one wrong answer)
Respuesta
-
The main method of treatment is chemotherapy
-
Origin from the pleura, pericardium, peritoneum, testicular envelopes.
-
A causal relationship with exposure to asbestos
-
There are a large percentage of patients with five years of survival
Pregunta 69
Pregunta
Which of the following statements about lung carcinoma is NOT correct
Respuesta
-
more prominent for developed countries
-
the main cause of cancer morbidity and mortality in women
-
there are 2 major histological types - small cell and non-small cell
-
has a high-sensitivity tumor marker for diagnosis
Pregunta 70
Pregunta
Which of the following statements for small cell lung cancer (SCLC) compared to non-small cell lung cancer (NSCLC) is true
Respuesta
-
SCLC is more radiosensitive
-
SCLC is less chemosensitive
-
SCLC is more likely to have a peripheral localization in the lung
-
Tendency towards early and rapid metastasis
Pregunta 71
Pregunta
73 years old man has an increasing pain in the lumbar segment of the spine, more pronounced at bedtime. From the history - a long-standing hypertonic; sometimes smokes 1-2 cigarettes a week. Physical status is normal. Laboratory studies have found elevated serum alkaline phosphatase levels. From radiograph of the lumbar segment - a lytic bone lesion of the third lumbar vertebra.
Which of the following cancers is the most likely diagnosis:
Pregunta 72
Pregunta
Immunotherapy in lung carcinoma is performed with
Respuesta
-
BCG vaccine
-
Immunomodulators
-
Nivolumab, Pembrolizumab
-
There is no true answer
Pregunta 73
Pregunta
Pulmonary carcinoma metastasizes most often in
Pregunta 74
Pregunta
The recommended behavior of a General Practitioner in a patient with a blood clot is
Pregunta 75
Pregunta
What is the significance of EGFR expression Studies, KRAS mutation and ALK in non-small cell lung carcinoma
Respuesta
-
They are prognostic markers for survival
-
Reference markers for surgery
-
EGFR-TKI response markers
-
Possibility for personalized treatment
Pregunta 76
Pregunta
Which factors are not carcinogens for lung cancer
Respuesta
-
Smoking
-
Radiation
-
A diet rich in fat
-
Avitaminoses
Pregunta 77
Pregunta
Hypertrophic pulmonary osteoarthropathy is
Respuesta
-
Symptom of Peak Lung Cancer Symptom
-
Complication of radiotherapy
-
Paraneoplastic syndrome in lung carcinoma
-
Paraneoplastic syndrome in ovarian cancer
Pregunta 78
Pregunta
Contemporary molecular genetic tests on lung cancer biopsy specimen include
Respuesta
-
EGFR mutation
-
PDF
-
ALK
-
All answers are correct
Pregunta 79
Pregunta
Peripheral lung lesions suspect for carcinoma are indicated for further diagnostic testing with
Pregunta 80
Pregunta
For pleural effusion suspicious of lung carcinoma indicated is
Respuesta
-
X-ray and consultation with a pulmonologist
-
VATS (video-assisted thoracoscopy) with a biopsy
-
Magnetic resonance tomography
-
Positron emission tomography
Pregunta 81
Pregunta
Palliative therapy in lung cancer is
Respuesta
-
associated with a high risk of fatal toxicity
-
associated with increased life expectancy at reduced quality of life
-
followed by a 1 year life expectancy at improved quality of life
-
does not change life expectancy
Pregunta 82
Pregunta
Which statement is true for Luminous type A?
Respuesta
-
ER, PR- positive, HER2- negative, low Ki 67
-
ER PR- positive, HER2-positive, low Ki 67
-
ER, PR- positive, HER2- negative, high Ki 67
-
There is no correct answer
Pregunta 83
Pregunta
Which statement is wrong for Luminous Type B?
Respuesta
-
ER, PR- positive, HER2- negative, high Ki 67
-
ER, PR- positive, HER2- overexpression, regardless of Ki 67
-
ER, PR- positive, HER2- positive, low Ki 67
-
No wrong answer
Pregunta 84
Pregunta
In non-luminous type we observe?
Respuesta
-
ER, PR- negative, HER2- overexpression
-
ER, PR- positive, HER2-positive, Ki 67 low
-
ER, PR- positive, HER2- negative
-
There is no correct answer
Pregunta 85
Pregunta
Genetic mutations in breast carcinoma are
Respuesta
-
BRCA 1, BRCA 2
-
BRCA1, BRCA2, p53
-
ALK, PDL 1
-
All listed
Pregunta 86
Pregunta
Standard treatment for luminal type A breast carcinoma includes
Pregunta 87
Pregunta
Standard treatment for luminal type B HER 2 negative breast carcinoma includes
Pregunta 88
Pregunta
Standard treatment for luminal type B HER 2-positive breast carcinoma includes
Respuesta
-
chemotherapy, anti-HER 2 therapy
-
chemotherapy, hormone therapy, anti- HER 2 therapy
-
hormone therapy, chemotherapy
-
there is no true answer
Pregunta 89
Pregunta
Treatment in triple negative breast carcinoma includes
Respuesta
-
chemotherapy
-
hormone therapy
-
chemotherapy + hormone therapy
-
chemotherapy, hormone therapy, anti- HER2
Pregunta 90
Pregunta
Specify the standard treatment algorithm for breast cancer T2N1M0 without hormonal expression
Respuesta
-
PCT, surgery, radiotherapy
-
Surgery, PCT, radiotherapy
-
Radiotherapy, surgery, PCT
-
The three answers are correct
Pregunta 91
Pregunta
Specify the main tumor marker for diagnosis of breast cancer
Pregunta 92
Pregunta
The biological characteristic of the "triple-negative" breast cancer requires (choose one wrong answer)?
Pregunta 93
Pregunta
Indicate which target drugs are used in HER positive breast cancer
Respuesta
-
Avastin, Panitumumab, Cetuximab
-
Herceptin, Lapatinib, Perjeta
-
Tarceva, Iressa, Avastin
-
Herceptin, Nivolumab, Crisotinib
Pregunta 94
Pregunta
A method of early detection (screening) of breast cancer is
Pregunta 95
Pregunta
The default markers for breast cancer are
Respuesta
-
The total CEA and CA 15-3
-
HER, estrogen and progesterone receptors, Ki 67
-
Total CEA and CA 125
-
Serum alkaline phosphatase and LDH
Pregunta 96
Pregunta
In which % of cases the breast cancer has a genetic predisposition
Pregunta 97
Pregunta
Triple-negative breast cancer belong to which of the listed histological groups?
Respuesta
-
Luminal A
-
Luminal B
-
Basal-like
-
"Normal" -like
Pregunta 98
Pregunta
A recommended age group to start screening for early detection of breast carcinoma is
Respuesta
-
women over 60 years of age
-
women over 50 years of age
-
women aged 50-69
-
family-related women, regardless of age
Pregunta 99
Pregunta
All of these factors are associated with a decreased risk of developing breast cancer except for
Respuesta
-
Negative history of breastfeeding
-
First pregnancy before 18 years of age
-
Men after 15 years of age
-
Natural menopause before 42 years of age
Pregunta 100
Pregunta
Which of the following features is associated with an unfavorable prognosis for breast carcinoma