Oncogene Classification

Question

Give an example of a Class 1 Onocgene- Growth Factors

Answer 1

Forms a PDGF(Beta) chain

Answer 2

Forms a IPGF(Beta) chain

Answer 3

Forms a IGF1(Beta) chain

Answer 4

A virus produces extra growth factor as it replicates

Answer 5

A cell begins to make it's own growth factor through growth factor genes

Answer 6

A cell begins to steal growth factor from surrounding cells

Answer 7

Growth Factor Receptors

Answer 8

Growth Factors

Answer 9

Intracellular Transducers

Answer 10

....bind permanently to their ligand and so become constitutionally active

Answer 11

... no longer need their ligand to activate become constitutionally active

Answer 12

...form a constitutionally active dimer

Answer 13

...no longer needs to dimerise to activate

Answer 14

Family of tyrosine kinase receptors that bind to EGF

Answer 15

Family of tyrosine kinase receptors that bind to TGFB

Answer 16

Family of tyrosine kinase receptors that bind to IGF1

Answer 17

Glutamic Acid

Answer 18

A tyrosine kinase agonist?

Answer 19

A humanised monoclonal antibody

Answer 20

An Erb-B agonist

Answer 21

Tyrosine Kinase

Answer 22

Growth factors

Answer 23

Transcription factors

Answer 24

Intracellular transducers

Answer 25

The cell type

Answer 26

The stage of the cell cycle

Answer 27

The age of the cycle

Answer 28

Relay information to the nucleus to regulate gene transcription

Answer 29

Relay information to the ribosomes to regulate protein synthesis

Answer 30

Relay information to the Golgi Complex to regulate cell receptor production

Answer 31

A modified lipid

Answer 32

A modified glycoprotein

Answer 33

A modified phospholipid

Answer 34

A phosphate on Tyr 527 in its inactive form & the SH2 domain

Answer 35

A phosphate on Tyr 527 in its inactive form & the SH3 domain

Answer 36

A phosphate on Tyr 537 in its inactive form & the SH2 domain

Answer 37

Protein- protein interaction

Answer 38

Protein- phosphotyrosine interaction

Answer 39

Protein-phosphoserine interactoin

Answer 40

Proline rich; Pro-X-X-Pro

Answer 41

Histadine rich; His-X-X-His

Answer 42

Gycine rich; Gy-X-X-Gly

Answer 43

For the protein to be at the membrane

Answer 44

For the protein to be cytosolic

Answer 45

The SH2 domain then releases the regulatory domain and binds to P-Tyrosine Kinase

Answer 46

It's dephosphorylated by a phosphatase at the membrane at Tyr 527

Answer 47

It's phosphorylated by the tyrosine kinase at Tyr 527

Answer 48

416 on the activation lip

Answer 49

417 on the activation lip

Answer 50

418 on the activation lip

Answer 51

Loss of regulatory domain (last 19 amino acids) so it cannot be phosphorylated

Answer 52

Loss of SH2 domain so it cannot bind to regulatory domain when phosphorylated

Answer 53

Modified lipid binds permanently to the membrane

Answer 54

Acetylation

Answer 55

Methylation

Answer 56

Farnesylation

Answer 57

At the C and N terminus

Answer 58

In the centre

Answer 59

To bind GTP

Answer 60

To bind GDP

Answer 61

To bind downstream molecules

Answer 62

Guanine Nucleotide Disassociation Inhibitors

Answer 63

Guanine Nucleotide Dimerisation Inhibitors

Answer 64

Gunanine Nucleotide Decamerisation Inhibitors

Answer 65

By molecules recruited to the tyrosine receptor

Answer 66

Bind to Ras and prevent activation

Answer 67

Bind to Ras and prevent de-activation

Answer 68

Binds Ras to membrane

Answer 69

Binds Ras to TK receptor

Answer 70

Binds Ras to Raf

Answer 71

2- both in the middle

Answer 72

2- one on each end

Answer 73

1 in the middle

Answer 74

1 at the N terminus

Answer 75

1 at the C terminus

Answer 76

Binds to SH3 domain

Answer 77

Binds to SH2 domain

Answer 78

Binds to discrete domain

Answer 79

Growth factors

Answer 80

Cellular Transporters

Answer 81

Growth Factor Receptors

Answer 82

Transcription factors

Answer 83

Leu Zipper

Answer 84

His zipper

Answer 85

Ala zipper

Answer 86

Near the center

Answer 87

Near the c-terminus

Answer 88

Near the n-terminus

Answer 89

Defines family member

Answer 90

Determines where in the DNA c-jun binds

Answer 91

As a homodimer

Answer 92

As a heterodimer

Answer 93

Dephosphorylation by PKC

Answer 94

Phosphorylation by JNK (ERK parallel protein)

Answer 95

Dephosphorylation by PKB

Answer 96

Phosphorylation by JNK

Answer 97

Unique sequence

Answer 98

Delta Domain

Answer 99

Leu zipper

Answer 100

TCF/AFK to be activated by ERK

Answer 101

AFK to be activated by ERK

Answer 102

TCF to be activated by ERK

Answer 103

Transcription factors

Answer 104

Ribosomal proteins

Answer 105

Growth factors

Answer 106

It's activity is increased further by phosphorylation

Answer 107

It's activity is increased further by methylation

Answer 108

By Jnk/Erk

Answer 109

5-10 seconds

Answer 110

Halts protein turnover & allows protein levels to build up

Answer 111

Increases protein turnover so only new proteins are involved in the cell cycle

Answer 112

Max, so the dimer only forms when Myc levels are signaled to rise

Answer 113

Mic, so the dimer only forms when Max levels are signalled to rise

Answer 114

They block jun transcription sites

Answer 115

They block jun expression promoters

Answer 116

They block myc expression promoters

Answer 117

Myc levels are always higher than Max

Answer 118

Max levels are always higher than myc

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Oncogene Classification

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