Tumor Suppressors

Descripción

Year 2 Test sobre Tumor Suppressors, creado por gina_evans0312 el 03/12/2013.
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Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312 hace casi 11 años
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Resumen del Recurso

Pregunta 1

Pregunta
What is the role of the Rb Susceptibility gene?
Respuesta
  • Nuclear transcription factor
  • Nuclear phosphatases
  • Nuclear phosphorylases

Pregunta 2

Pregunta
What protein does Rb bind to?
Respuesta
  • E2F
  • FF2
  • EF2

Pregunta 3

Pregunta
What is the role of the protein bound to Rb?
Respuesta
  • Transcription factor
  • Kinase
  • Phosphatase

Pregunta 4

Pregunta
What are the target genes of the Rb bound protein?
Respuesta
  • dNTP producing genes
  • Transcription factor producing genes
  • Growth factor producing genes

Pregunta 5

Pregunta
How is Rb phosphorylated and deactivated?
Respuesta
  • By Cyclin
  • By CDK
  • By a cyclin/CDK dimer

Pregunta 6

Pregunta
What protein phosphorylates CDK?
Respuesta
  • CAK
  • CAD
  • CAB

Pregunta 7

Pregunta
Which forms first during G1?
Respuesta
  • CDK/Cyclin D
  • CDK/Cyclin E

Pregunta 8

Pregunta
What causes the production of Cyclin/CDK E &D?
Respuesta
  • Jun Activity
  • AP1 Activity
  • Myc Activity

Pregunta 9

Pregunta
Which is required to activate E2F?
Respuesta
  • Cyclin/CDK D
  • Cyclin/CDK E
  • Both
  • Neither

Pregunta 10

Pregunta
Name 3 CDK inhibitors
Respuesta
  • p13
  • p21
  • p12
  • p16
  • p27
  • p19

Pregunta 11

Pregunta
Which of the following binds to CDK, & twists its head to block the active site?
Respuesta
  • p16
  • p12
  • p19

Pregunta 12

Pregunta
Which of the following bind to cdk with cyclin and physically block the active site?
Respuesta
  • p21
  • p27
  • p19

Pregunta 13

Pregunta
How are the CDK inhibitors controlled?
Respuesta
  • Phosphorylation & degredation
  • Phosphorylation & activation

Pregunta 14

Pregunta
How long is the bp sequence p53 binds to?
Respuesta
  • 10 bp
  • 12 bp
  • 15 bp

Pregunta 15

Pregunta
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Respuesta
  • D-A-E-C-B
  • D-A-C-E-B
  • A-D-C-E-B
  • B-A-D-E-C

Pregunta 16

Pregunta
How does p53 work in its active form?
Respuesta
  • As a monomer
  • As a dimer
  • As a tetramer

Pregunta 17

Pregunta
What does p53 bind to when active?
Respuesta
  • TATA boxes
  • E-boxes
  • Damaged DNA

Pregunta 18

Pregunta
What can cause the activation of p53?
Respuesta
  • Acetylation
  • Phosphorylation
  • Ionising radiation

Pregunta 19

Pregunta
What does p53 do if activated in G1?
Respuesta
  • Repairs DNA
  • Reverts the cell back to G0
  • Forces cell through mitotic cycle

Pregunta 20

Pregunta
What happens if p53 is activated after G1?
Respuesta
  • Bax is transcribed- it initiates apoptosis
  • Bax is transcribed- It initiates S phase
  • Bax is transcribed- It inhibits M phase

Pregunta 21

Pregunta
Where do mutations causing non-function tend to occur in p53?
Respuesta
  • The DNA binding domain
  • The damaged DNA binding domain
  • The signalling domain

Pregunta 22

Pregunta
How is p53 removed from the cell?
Respuesta
  • MDM2
  • MDM
  • MDM1
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