Pregunta 1
Pregunta
What is the role of the Rb Susceptibility gene?
Pregunta 2
Pregunta
What protein does Rb bind to?
Pregunta 3
Pregunta
What is the role of the protein bound to Rb?
Respuesta
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Transcription factor
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Kinase
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Phosphatase
Pregunta 4
Pregunta
What are the target genes of the Rb bound protein?
Pregunta 5
Pregunta
How is Rb phosphorylated and deactivated?
Respuesta
-
By Cyclin
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By CDK
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By a cyclin/CDK dimer
Pregunta 6
Pregunta
What protein phosphorylates CDK?
Pregunta 7
Pregunta
Which forms first during G1?
Respuesta
-
CDK/Cyclin D
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CDK/Cyclin E
Pregunta 8
Pregunta
What causes the production of Cyclin/CDK E &D?
Respuesta
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Jun Activity
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AP1 Activity
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Myc Activity
Pregunta 9
Pregunta
Which is required to activate E2F?
Respuesta
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Cyclin/CDK D
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Cyclin/CDK E
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Both
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Neither
Pregunta 10
Pregunta
Name 3 CDK inhibitors
Pregunta 11
Pregunta
Which of the following binds to CDK, & twists its head to block the active site?
Pregunta 12
Pregunta
Which of the following bind to cdk with cyclin and physically block the active site?
Pregunta 13
Pregunta
How are the CDK inhibitors controlled?
Pregunta 14
Pregunta
How long is the bp sequence p53 binds to?
Pregunta 15
Pregunta
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Respuesta
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D-A-E-C-B
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D-A-C-E-B
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A-D-C-E-B
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B-A-D-E-C
Pregunta 16
Pregunta
How does p53 work in its active form?
Respuesta
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As a monomer
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As a dimer
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As a tetramer
Pregunta 17
Pregunta
What does p53 bind to when active?
Respuesta
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TATA boxes
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E-boxes
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Damaged DNA
Pregunta 18
Pregunta
What can cause the activation of p53?
Respuesta
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Acetylation
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Phosphorylation
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Ionising radiation
Pregunta 19
Pregunta
What does p53 do if activated in G1?
Pregunta 20
Pregunta
What happens if p53 is activated after G1?
Respuesta
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Bax is transcribed- it initiates apoptosis
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Bax is transcribed- It initiates S phase
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Bax is transcribed- It inhibits M phase
Pregunta 21
Pregunta
Where do mutations causing non-function tend to occur in p53?
Pregunta 22
Pregunta
How is p53 removed from the cell?