Beta Cells and Insulin

Descripción

(Insulin & Glucagon) Year 2 Test sobre Beta Cells and Insulin, creado por gina_evans0312 el 04/03/2014.
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Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312 hace más de 10 años
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Resumen del Recurso

Pregunta 1

Pregunta
Pre-Proinsulin contains an R.E.R signal that moves it to the golgi
Respuesta
  • True
  • False

Pregunta 2

Pregunta
What is the role of the C-peptide part of the insulin chain
Respuesta
  • Formation of disulphide bonds between the alpha and beta chains
  • Formation of Fe-S bonds between the alpha and beta chains
  • Formation of peptide bonds between the alpha and beta chains

Pregunta 3

Pregunta
Pro-insulin is made of the alpha & beta chains and the c peptide
Respuesta
  • True
  • False

Pregunta 4

Pregunta
Which of the following cleave the c-peptide from the proinsulin?
Respuesta
  • Endopeptidase
  • Enteropeptidase
  • Carboxypeptidase

Pregunta 5

Pregunta
What form does newly made insulin take?
Respuesta
  • Granules
  • Crystals
  • Rods

Pregunta 6

Pregunta
The cleaved C-peptide is released along with the insulin
Respuesta
  • True
  • False

Pregunta 7

Pregunta
Why do Mannoheptulases inhibit insulin release?
Respuesta
  • The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit
  • MHLs block excretory channels
  • MHLs prevent the movement of insulin to the RER

Pregunta 8

Pregunta
Optimum insulin secretion occurs at 8mM
Respuesta
  • True
  • False

Pregunta 9

Pregunta
Why is optimal secretion of insulin at 8mM
Respuesta
  • GLUT 2 & glucokinase have Kms of 8
  • Not gonna put anything else
  • Because reasons

Pregunta 10

Pregunta
Insulin secretion relies on ATP dependent K+ channels
Respuesta
  • True
  • False

Pregunta 11

Pregunta
K+ buildup causes Ca2+ influx and insulin secretion
Respuesta
  • True
  • False

Pregunta 12

Pregunta
Which drugs block K+ channels and mimic high glucose?
Respuesta
  • Sulpynoylurea
  • Sulphinomides
  • Sulphinomics

Pregunta 13

Pregunta
Diazoxide causes insulin secretion by keeping channels open
Respuesta
  • True
  • False

Pregunta 14

Pregunta
High doses of adrenaline stimulates insulin secretion through _ receptors
Respuesta
  • Alpha 1
  • Alpha 2
  • Beta 1
  • Beta 2

Pregunta 15

Pregunta
Low concs of adrenaline inhibit insulin secretion through Beta receptors
Respuesta
  • True
  • False

Pregunta 16

Pregunta
Insulin is catabolic
Respuesta
  • True
  • False

Pregunta 17

Pregunta
Insulin stimulates _ activity in order to reduce cAMP levels
Respuesta
  • Phosphodiesterases
  • Adenylate cyclase

Pregunta 18

Pregunta
Which of the following metabolites are reduced?
Respuesta
  • Fatty Acyl CoA
  • Acetyl CoA
  • Malonyl CoA
  • Palmitite

Pregunta 19

Pregunta
Inc. Phosphorylation of tyrosine kinase by insulin causes what?
Respuesta
  • Inc tyrosine kinase activity
  • Inc phosphatase activity
  • Inc Adenylate cyclase activity
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