Pregunta 1
Pregunta
Pre-Proinsulin contains an R.E.R signal that moves it to the golgi
Pregunta 2
Pregunta
What is the role of the C-peptide part of the insulin chain
Respuesta
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Formation of disulphide bonds between the alpha and beta chains
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Formation of Fe-S bonds between the alpha and beta chains
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Formation of peptide bonds between the alpha and beta chains
Pregunta 3
Pregunta
Pro-insulin is made of the alpha & beta chains and the c peptide
Pregunta 4
Pregunta
Which of the following cleave the c-peptide from the proinsulin?
Respuesta
-
Endopeptidase
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Enteropeptidase
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Carboxypeptidase
Pregunta 5
Pregunta
What form does newly made insulin take?
Pregunta 6
Pregunta
The cleaved C-peptide is released along with the insulin
Pregunta 7
Pregunta
Why do Mannoheptulases inhibit insulin release?
Respuesta
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The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit
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MHLs block excretory channels
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MHLs prevent the movement of insulin to the RER
Pregunta 8
Pregunta
Optimum insulin secretion occurs at 8mM
Pregunta 9
Pregunta
Why is optimal secretion of insulin at 8mM
Pregunta 10
Pregunta
Insulin secretion relies on ATP dependent K+ channels
Pregunta 11
Pregunta
K+ buildup causes Ca2+ influx and insulin secretion
Pregunta 12
Pregunta
Which drugs block K+ channels and mimic high glucose?
Respuesta
-
Sulpynoylurea
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Sulphinomides
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Sulphinomics
Pregunta 13
Pregunta
Diazoxide causes insulin secretion by keeping channels open
Pregunta 14
Pregunta
High doses of adrenaline stimulates insulin secretion through _ receptors
Respuesta
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Alpha 1
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Alpha 2
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Beta 1
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Beta 2
Pregunta 15
Pregunta
Low concs of adrenaline inhibit insulin secretion through Beta receptors
Pregunta 16
Pregunta
Insulin is catabolic
Pregunta 17
Pregunta
Insulin stimulates _ activity in order to reduce cAMP levels
Respuesta
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Phosphodiesterases
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Adenylate cyclase
Pregunta 18
Pregunta
Which of the following metabolites are reduced?
Respuesta
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Fatty Acyl CoA
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Acetyl CoA
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Malonyl CoA
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Palmitite
Pregunta 19
Pregunta
Inc. Phosphorylation of tyrosine kinase by insulin causes what?