MCB Lecture 1

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Reaction Thermodynamics
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Pregunta Respuesta
What is the relationship between ΔG, ΔH, and ΔS?
Gibbs Free Energy? The energy of the reaction available to do work.
Gibbs Free Energy Plot
Exergonic ΔG is negative. Free energy released. Favourable, spontaneous.
Endergonic ΔG is positive. Free energy absorbed. Unfavourable, nonspontaneous.
Exothermic ΔH is negative: Heat released.
Endothermic ΔH is positive: Heat absorbed.
ΔS is negative Less disorder.
ΔS is positive More disorder.
Explain how ∆G° is different from ∆G'°. ∆G° is the Standard Gibbs Free Energy change of a reaction (under standard conditions). ∆G'° is the Standard Gibbs Free Energy change (under Biochemistry standard conditions).
What are ∆G'° conditions? - 298 K (25 degrees Celcius) - Gases at partial pressure 101.3 kPa (1 atm) - Well-buffered solution at pH 7, [H+] = 10^-7, Mg^2+ = 1 mM.
What are ∆G° conditions? - 298 K (25 degrees Celcius) - Gases at partial pressure 101.3 kPa (1 atm) - Reactants and Products at 1 M, [H+] = 1 M --> pH 0.
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