Guanylate Cyclase

Pregunta	Respuesta
[3,5-cGMP] is	10-100x lower than cAMP
When is 3,5-cGMP produced?	In response to drugs/toxins
Guanylate cyclase is a homo/hetero-dimer/monomer/multimer	Homodimer
Where is G.C's dimerisation domain found?	Inside the cell
Where is G.C's ligand recognition site?	Extracellular
How many amino acids are different between catalytic sites 1 & 2?	2
How many types of guanylate cyclase are there?	8- only 3 have known ligands
What are the ligands for G.C's Types A & B?	Atrial Natiuretic Peptides
What are Atrial Natiuretic Peptides?	Produced by the heart to control blood pressure, diuresis & natriuresis
What is the ligand for G.C Type C?	Guanylin & uroguanylin
Where are guanylin/urogaunylin produced?	The gastro-intestinal tract
What is type C used to regulate?	Na+, Cl- and water transport
Which type of G.C does E.Coli Stable Enterotoxin bind to?	Type C

Resumen del Recurso

	Creado por gina_evans0312 hace alrededor de 11 años