PKB Activation Through RAS

Pregunta	Respuesta
When T.K is phosphorylated, which subunit of PI-3-Kinase binds first?	P85
What allows the regulatory subunit to bind?	The Sh2 domain
Name the catalytic subunit of PI-3-Kinase	p110
When PI-3-Kinase is complete, what binds?	Activated RAS
Role 1 of PI-3-Kinase	Phosphorylation if PIP2 to PIP3
Part of PDK1 that allows PIP3 interaction	Plectstrin homology domain
Where does PDK1 activation occur?	The membrane
What membrane molecule does PKB bind to?	Phosphatidynositol-3,4-bisphosphate
Inactive PKB Structure	Has a pH domain and an activation lip hiding the kinase
Part of PKB that binds to PIP2	pH domain
PKB binds to PIP2	Causing partial activation
Partial Activation caused by	PDK1 phosphorylating its activation lip
Full activation caused by	PDK2 phosphorylating its C terminus
PKB moves GLUT4 to membrane (T/F)	True
PKB causes Glycogen breakdown (T/F)	False- it causes glycogen synthesis
PKB increases protein synthesis (T/F)	True
PKB phosphorylates Glycogen Synthase Kinase (T/F)	True- this prevents the deactivation of glycogen synthase
PDK1 directly phosphorylates PKB (T/F)	True
What allows the different proteins to bind to T.K?	The aa surrounding the tyrosine kinase

Resumen del Recurso

	Creado por gina_evans0312 hace alrededor de 11 años