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334430
Pancreas Pathology
Descripción
Doctorate (Systems Pathology) Pathology Mapa Mental sobre Pancreas Pathology, creado por melian.yates el 06/11/2013.
Sin etiquetas
pathology
systems pathology
pathology
systems pathology
doctorate
Mapa Mental por
melian.yates
, actualizado hace más de 1 año
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Creado por
melian.yates
hace alrededor de 11 años
148
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Resumen del Recurso
Pancreas Pathology
Exocrine
Digestive
Proteolytic enzyme content can damage adjacent tissues
Structure
Lobules of exocrine pancreatic acini, separated by fine fibrous trabeculae
Cat
One major pancreatic duct which shares a common entry into the duodenum with the common bile duct
Dog
May be several major pancreatic ducts
No common entry w/ the bile duct
Developmental Conditions
Pancreatic Acinar Atrophy
Dogs
Juvenile onset
German Shepherds: Autosomal recessive inheritance
Rough coated collies & English setters: Familial disease
Likely autoimmune (Large #'s of lymphocytes & plasma cells targeting exocrine pancreas => Fibrosis)
Islets of Langerhans are normal
Most common cause of Exocrine pancreatic insufficiency (EPI) - Dogs
Clinical signs by 6-12 months of age
Acquired Conditions
Exocrine pancreatic insufficiency
Fatty diarrhoea (steatorrhoea)
Insufficient lipase => undigested fat in diarrhoea => malabsorption sydrome
Weight loss (Cachexia)
Voracious appetite
Pica, Coprophagia
Concurrent small intestine bacterial overgrowth (SIBO)
Pancreatic calculi (Pancreolithiasis)
Uncommon
Incidental PM finding (Cattle)
Interstitial Pancreatitis
Acute
Cats
Systemic toxoplasmosis
Chronic
Cats
Often concurrent w/ Cholangitis & Enteritis (Triaditis)
Extension of process that commences in the ducts
Usually ascending infection of intestinal bacteria
Also, migrating parasites
Horses
Histologically
Hyperplasia of pancreatic ducts & periductular fibrosis & inflammation
Can lead to exocrine pancreatic insufficiency/diabetes mellitus
Necrotising Pancreatitis
Acute Pancreatic Necrosis
Imp. in Dog (Small breeds)
Less common in Cats
Activation of Trypsinogen => Trypsin w/in the pancreas => activation of cascade of pancreatic proenzymes leading to autodigestion & tissue damage
Occurs due to fusion of zymogen granules with lysosomes
Release of pancreatic enzymes into circulation => Hepatic necrosis, Pulmonary oedema, Interstitial pneumonia, Myocardial injury (& arrhythmias), Shock & DIC
Dystrophic mineralization of necrotic abdominal fat (saponification)
Necrosis of the pancreas, adjacent connective tissues & abdominal fat
Blood vessels also involved => Haemorrhage, thrombosis, ischaemia
Sequelae:
Complete resolution (fibrosis & nodular regeneration)
Chronic relapsing "smouldering" pancreatitis => Eventual complete loss
Diabetes Mellitus (Destruction of Islets)
Nodular Hyperplasia
Common in older animals
Multiple nodules
Raised, smooth, grey or white
Non-functional
Often mistaken for Neoplasia
Neoplasia
Exocrine Adenomas
Rare, Solitary
Exocrine Carcinomas
Dog & Cat
Single or multiple/confluent, firm, white or pale yellow nodules
Non-functional
Aggressive
Invade adjacent tissues & pertoneum
Metastasize to liver
Obstruct bile flow => Jaundice
Endocrine
Metabolic
Structure
Islets of Langerhans (Small foci b/w acini)
Alpha, beta, gamma, PP(F) & other cells
Pancreatic Disease:
Alimentary tract signs: Maldigestion
Concurrent biliary duct obstruction
Jaundice (Cats - Triaditis)
Metabolic Disease
Endocrine pancreas
Recursos multimedia adjuntos
juvenile_pancreatic_atrophy (image/png)
pancreatic_carcinoma (image/png)
pancreatic_atrophy (image/png)
Nodular_hyperplasia (image/png)
Necrotising_pancreatitis (image/png)
steatorrhoea (image/png)
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