48449
Description
Flashcards by Bhavi Mistry, updated more than 1 year ago
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Created by Bhavi Mistry
over 11 years ago
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| Question | Answer |
| Agonist effects | Hypnotic Sedative anticonvulsant Antianxiety |
| Antagonist | Brings back to basal level (0) |
| Inverse agonist | anxiogenic Proconvulsant Convulsant |
| Antidepressants | delayed onset |
| Benzodiazipines | Quick onset Physical dependence the longer the half life the effect becomes anxiolytic/anticonvulsant |
| Side effects of Benzodiazipines | drowsiness, confusion, amnesia, reduced REM sleep |
| Busiporone | delayed onset (weeks) Anxiolytic 5HT1a antagonist Acute activation decreases 5HT release Chronic actuvation increases 5HT release due to receptor desensitisation |
| Side effects of busiporone | Nausea, diziness, headaches Ineffective against panick attacks |
| Phenobarbitone | Anticonvulsant Binds to GABAaR at low concentrations it prolongs GABAa opening at increased concentrations it opens GABAa in the absence of GABA |
| Propanolol | Removes peripheral sumptoms of anxiety Anxiolytic |
| Antihistamines | Drowsiness is a side effect Hypnotic |
| Fear response | Defensive response to negative stimuli |
| Anxiety | anticipation of fear in the absence of an external stimulus |
| Generalised anxiety | State of ongoing anxiety (unfocused, unclear) |
| Social | fear of interacting with others |
| Phobias | Strong fear of objects/situations etc |
| Post traumatic anxiety | Triggered by past stressful situations |
| OCD | ritualistic driven by irrational anxiety |
| alpha 1 GABA subunit | Sedative |
| Alpha 6 GABAa Subunit | insensitive to benzodiazipines |
| Site of action of benzodiazipines | Alpha 2 Alpha 3 Alpha 5 |
| GABAa Receptor sub units | 2 Alpha 2 Beta 1 Gama |
| Subunits present in the brain | 6 alpha 3 beta 3 gamma |
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