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50203
CHRONIC INFLAMMATION 1
Description
Bio Med and Pathology Mind Map on CHRONIC INFLAMMATION 1, created by aahughes on 18/04/2013.
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bio med and pathology
bio med and pathology
Mind Map by
aahughes
, updated more than 1 year ago
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aahughes
over 11 years ago
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Resource summary
CHRONIC INFLAMMATION 1
An inflammatory response of prolonged duration - weeks,months or indefinite
Usually PRIMARY but occasionally follows ACUTE
Provoked by persistence of causative agent
Characterised with inflammation at the same time attempts healing
Involved lymphocytes and Macrophages
FIBROBLASTS are activated laying down new COLLAGEN
AETIOLOGICAL AGENTS
RESISTANT INFECTIUOUS AGENTS: organisms that resist host defence
Tend to avoid phagocytosis and do not produce toxins
ie mycobacterium tuberculosis
MICRO-ORGANISMS THAT PERSIST IN DAMAGED REGIONS
Persist in damaged area where they are protected by pus /abscess cavity
IRRITANT NON-LIVING FOREIGN OBJECTS
Cannot be removed by enzymatic breakdown ie wood splinter
SOME CASES MAY OCCUR IN NORMAL TISSUE
Disease caused by abnormality in the body's response t its own tissues (auto-immunity)
UNKNOWN:underlying cause unknown ie Crohns disease
Intestinal bleeding, ulceration,nausea, fever, abdominal pain
HOW DOES CHRONIC COME ABOUT?
DE NOVO: causative agent produces no/or mild acute response
Progression from acute if original stimuli persists
Chronic occurs after repeated episodes of acute
DE NOVO: in most cases there is no phase of acute
has all histological features of chronic ie no neutrophils
Transplant rejection involves chronic cell infiltration
PROGRESSION FROM ACUTE INFLAMMATION:
Most cases do not progress to acute
Cases that do are SUPPURATION: abscess or foreign object
Have the tendency to provoke granulomatous inflammation
RECURRENT ACUTE EPISODES:
Usually turn into Chronic
eg chronic cholecystitis - Gallstones
starts to replace gall bladder muscle wall into fibrous tissue
MICROSCOPIC FEATURES:
Mostly MACROPHAGES, LYMPHOCYTES and PLASMA CELLS
few EOSINOPHILS and NEUTROPHILS
Tissue destruction (necrosis)
EXUDATION OF FLUID is not prominent
Production of fibrous tissue from granulation tissue
ACCUMULATION OF MACROPHAGES AND LYMPH OCCUR IN 3 WAYS
RECRUITMENT FROM CIRCULATION
LOCAL PROLIFERATION
PROLONGED SURVIVAL AND IMMOBILISATION OF INFLAMMED AREA
CELLULAR CO-OPERATION
B- on contact with antigen form plasma cells (antibodies)
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