691960
Renal Concentrating
mech review
- Proximal Convoluted Tubule
- over 65% of filtrate is reabsorbed here (most of
the Na, Cl and other anions passively follow),
water passively follows Na; responsible for
reabsorbing all of the filtered glucose, amino
acids, proteins, ketones, and vitamins
- over 65% of filtrate is reabsorbed here (most of
the Na, Cl and other anions passively follow),
water passively follows Na; responsible for
reabsorbing all of the filtered glucose, amino
acids, proteins, ketones, and vitamins
- Descending Loop of Henle
- large amts of water are
passively reabsorbed b/c
of high medullary
concentration gradient
- large amts of water are
passively reabsorbed b/c
of high medullary
concentration gradient
- Ascending Loop of Henle and Early Distal Tubule
- IMPERMEABLE to water, Cl is actively
reabsorbed, Na passively follows
- IMPERMEABLE to water, Cl is actively
reabsorbed, Na passively follows
- Late Distal Convoluted Tubules and Collecting Duct
- highly dependent on presence (or absence) of ADH and Aldosterone
- ADH is released due to increased
plasma osmolality when not drinking
OR decreased decreased circulating
blood volume
- Aldosterone in a dehydrated
animal causes active reabsorption
of Na and secretion of K
- ADH is released due to increased
plasma osmolality when not drinking
OR decreased decreased circulating
blood volume
- highly dependent on presence (or absence) of ADH and Aldosterone
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