Proto-Oncogenes & Loss of Growth Control

Descrição

Year 2 FlashCards sobre Proto-Oncogenes & Loss of Growth Control, criado por gina_evans0312 em 02-12-2013.
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FlashCards por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 aproximadamente 11 anos atrás
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Resumo de Recurso

Questão Responda
Oncogene Gene who's abnormal/mutated expression causes production of a malignant phenotype
Proto-oncogene Cellular homologue from which oncogene is derived
Tumor Suppressor Encodes a protein restricting cell growth
Conversion to Oncogene - Deletion/Point mutation Normal amounts of hyperactive proteins
Conversion to Oncogene - Gene Fusion Hyperactive fusion protein
Conversion to Oncogene - Chromosome Rearrangement Varies- Near a strong promoter, you get increased levels of normal protein
Conversion to Oncogene - Gene Replication Amplified levels of normal protein
No of Oncogene Classifications (At G0/G1 border 4
Competence Factors Increases production of cell cycle regulators
Example of a Progression Factor EGF, PDGF, FGF
Progression Factors Must increase in conjunction with CF's, or the CF's are degraded and the cell remains in G0
Example of Progression Factors Insulin or IGF1
Inhibitor Factors Prevent accidental entering of mitotic cycle (must be absent for G1 to be entered)
Example of Inhibitory Factors TGFB
Acutely Transforming Retroviruses Viruses containing a viral oncogene
No of Class of Tyrosine Kinase 9- each has different signalling molecules

Semelhante

Apoptosis
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Tumor Suppressors
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Other Recruitment By Activated Tyrosine Kinase
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Oncogene Classification
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Tyrosine Kinase
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Nuclear Signalling by Ras
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