8258150
Swelling in the leg
- Anatomy
- bones
- muscles
- femoral
artery
- femoral
vein
- adductor
canal
- popliteal
fossa
- bones
- Possible causes of leg
pain & swelling
- diabetic muscle infarction
- boil
- thigh strain/ injury
- superficial thrombophlebitis
- tumors (bone tumors)
- most common bone
tumors in children
- 2) Ewing's sarcoma
- children 10-15
- male>female
- site=diaphysis of long bones
- radiologically
- microscopically
- children 10-15
- 1) Osteosarcoma
- male>
female
- site:metaphysics
of long bones
- histopathology
- 1) pleomorphism
& mitotic figures
- 2) pink glassy
homogenous
osteoid formation
- 3) fibroblastic and
chondroblastic
formation
- biopsy
- types
- needle
- open
- needle
- types
- 1) pleomorphism
& mitotic figures
- radiologically
- neo-osteogenesis
- in subperiosteal layer
- codman's
triangle
- codman's
triangle
- from the central
mass
- sun burst
appearance
- sun burst
appearance
- in subperiosteal layer
- neo-osteogenesis
- types
- primary
- children
12-14
- genetic mutation in p53
or retinoblastoma
- children
12-14
- secondary
- adults >40
- post
irradiation
- adults >40
- primary
- clinical picture
- pain,
pathological
fracture
- progressively
growing
mass
- pain,
pathological
fracture
- stages of osteosarcoma
- investigations
- WBC
count
- to rule out inflammation and
infection
- to rule out inflammation and
infection
- hemoglobin
test
- test for anaemia caused by
cancer
- test for anaemia caused by
cancer
- ESR
- to check for inflammation associated with
cancer
- to check for inflammation associated with
cancer
- WBC
count
- Management of osteosarcoma
- chemotherapy
- methotrexate
- folic acid analog
- inhibits dihydrofolate reductase
- thus inhibits DNA synthesis
for replication of cells
- thus inhibits DNA synthesis
for replication of cells
- inhibits dihydrofolate reductase
- folic acid analog
- doxorubicin
- anticancer antibiotic
- several mechanisms of action
- causes DNA strand scission
- generate free radicals
- membrane disruption
- causes DNA strand scission
- several mechanisms of action
- anticancer antibiotic
- cisplatin
- acts like an alkylating agent
- cross links bases
- DNA strand breakage
- DNA strand breakage
- cross links bases
- acts like an alkylating agent
- methotrexate
- surgery
- amputation
- limb savage surgery
- autografts
- allografts
- rotatioplasty
- prosthetic implants
- autografts
- amputation
- chemotherapy
- Complications
- movement problems
- loss of a limb
- metastastis
- hematogenous spread
- liver
- lung
- brain
- bone
- liver
- hematogenous spread
- chemotherapy
side effects
- allopecia
- sterility
- GI complications
- allopecia
- Prognosis
- depends on
- age and general health
- location and size of tumor
- response to treatment
- age and general health
- depends on
- movement problems
- male>
female
- 2) Ewing's sarcoma
- benign
- melignant
- most common bone
tumors in children
- diabetic muscle infarction
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