11115010
Descrição
Quiz por Michael Jardine, atualizado more than 1 year ago
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Criado por Michael Jardine
aproximadamente 7 anos atrás
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Questão 1
Questão
GnIH means what?
Responda
-
Gonadotropin Inducing Hormone
-
Gonadotropin Inhibitory Hormone
Questão 2
Questão
Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?
Responda
-
Birds
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Mice
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Fish
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Salamanders
Questão 3
Questão
What does GnIH appear to be the “signaller” for in humans?
Responda
-
Stress-related suppression of reproduction
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Menopause
-
Puberty
-
Pregnancy-induced placentation changes
Questão 4
Questão
GnIH is also called:
Responda
-
RFamide-Related Peptide-3
-
FRamide-Related Peptide-3
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RFamide-Related Peptide-1
-
FRamide-Related Peptide-1
Questão 5
Questão
True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.
Responda
- True
- False
Questão 6
Questão
GnIH is:
Responda
-
Usually released into the portal system, but not in some animals (rats, mice).
-
Released into the portal system, but only in some animals (rats, mice).
Questão 7
Questão
A major similarity between organisms is that GnIH is always localised in the:
Responda
-
Dorsomedial nucleus of the hypothalamus
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Dorsomedial nucleus of the hippocampus
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Dorsal horn of the hypothalamus
-
Dorsal horn of the hippocampus
Questão 8
Questão
True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.
Responda
- True
- False
Questão 9
Questão
True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.
Responda
- True
- False
Questão 10
Questão
Advantages of using LAB AND DOMESTICATED animals as models include:
(select all that apply)
Responda
-
Well-adapted to labs
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Detailed knowledge of genetic background
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Transgenic manipulation allows specific focus
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Short generation time (longitudinal studies simple and comprehensive)
Questão 11
Questão
An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?
Responda
-
PTSD
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Alzheimer’s
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Cystic Fibrosis
-
Developmental disorders
Questão 12
Questão
Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas:
(select all that apply)
Responda
-
Cortical
-
Hippocampal
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Hypothalamic
Questão 13
Questão
The two main histopathological hallmarks of Alzheimer’s Disease (AD) are:
(select the two that apply)
Responda
-
Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases
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Intracellular Neurofibrillary Tangles (NFTs)
Questão 14
Questão
True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.
Responda
- True
- False
Questão 15
Questão
Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons)
(select all that apply)
Responda
-
Wolverines
-
Dolphins
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Polar Bears
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Tasmanian Tigers
-
Tasmanian Devils
Questão 16
Questão
The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:
Responda
-
Degu (Octodon degus)
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Guinea pig (Cavia porcellus)
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Naked mole-rat (Heterocephalus glaber)
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Domestic dog (Canis familiaris)
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Fat-tailed dunnart (Sminthopsis crassicaudata)
Questão 17
Questão
What age do Degus start presenting Alzheimer’s symptoms?
Responda
-
~3-4 years
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~4-5 years
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~5-6 years
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~6-7 years
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