PHSI3011 13-1 Circadian Rhythm and Disease

Descrição

PHSI3011 13-1 Circadian Rhythm and Disease
Michael Jardine
Quiz por Michael Jardine, atualizado more than 1 year ago
Michael Jardine
Criado por Michael Jardine aproximadamente 7 anos atrás
5
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Resumo de Recurso

Questão 1

Questão
The SCN is [primarily?] responsible for heaps of the Circadian Rhythm stuff. What is it?
Responda
  • Sagittal Central Nucleus
  • SupraCentral Nucleus
  • Sagittal Cortical Nucleus
  • SupraCortical Nucleus
  • SupraChiasmal Nucleus
  • Sagittal Chiasmal Nucleus

Questão 2

Questão
The CLOCK and BMAL1 genes are downregulated through negative feedback from which of the following?
Responda
  • PER
  • CRY
  • RORa
  • CCGs

Questão 3

Questão
Deepest sleep [normally] occurs at what time?
Responda
  • 12am
  • 1am
  • 2am
  • 3am
  • 4am
  • 4:30am
  • 6am
  • 6:30am

Questão 4

Questão
Jet lag results in a desynchrony between the sleep-wake cycle and the Melatonin rhythm on:
Responda
  • Blood transcriptome
  • Plasma transcriptome
  • Renal transcriptome
  • Mitochondrial transcriptome

Questão 5

Questão
Human circadian rhythm disorders that maintain a stable entrainment in relation to the 24-hour day-night cycle include:
Responda
  • Delayed Sleep Phase Disorder (DSPD)
  • Advanced Sleep Phase Disorder (ASPD)
  • Non-24-Hour Sleep-Wake Syndrome
  • Irregular Sleep-Wake Rhythm (ISWR)
  • Shift Work Sleep Syndrome
  • Time Zone Change Syndrome
  • Free-Running Disorder (FRD)

Questão 6

Questão
Free-Running Disorder (FRD) is:
Responda
  • A progressive pattern of 1- to 2- hour delays in sleep onset and wake times
  • Temporally disorganised and variable episodes of sleeping and waking behaviour with short sleep periods of a few hours that are distributed randomly through the day and night
  • Somnambulism
  • Sleepwalking

Questão 7

Questão
The endogenous cycle is how many hours?
Responda
  • 23
  • 24
  • 25

Questão 8

Questão
Mutations in CLOCK or PER3 can result in Delayed Sleep Phase Disorder (DSPD). This has been associated with metabolic & psychiatric disorders (e.g. depression, schizophrenia), but is also associated with which of the following:
Responda
  • Extreme eveningness preference
  • Extreme morningness preference

Questão 9

Questão
Treatments of human circadian rhythm disorders include:
Responda
  • Timed melatonin administration
  • Phase resetting – bright light administration
  • Melatonin agonists
  • Toughening the fuck up

Questão 10

Questão
Disruption of circadian rhythms can lead to:
Responda
  • Metabolic Imbalance
  • Disruption in melatonin levels
  • Disruption in blood glucose levels
  • Insulin resistance
  • Crankiness

Questão 11

Questão
True or false: Circadian rhythm disruptions have been linked to cancer.
Responda
  • True
  • False
  • ...true AND false.

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