11115010
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
about 7 years ago
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Question 1
Question
GnIH means what?
Answer
-
Gonadotropin Inducing Hormone
-
Gonadotropin Inhibitory Hormone
Question 2
Question
Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?
Answer
-
Birds
-
Mice
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Fish
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Salamanders
Question 3
Question
What does GnIH appear to be the “signaller” for in humans?
Answer
-
Stress-related suppression of reproduction
-
Menopause
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Puberty
-
Pregnancy-induced placentation changes
Question 4
Question
GnIH is also called:
Answer
-
RFamide-Related Peptide-3
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FRamide-Related Peptide-3
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RFamide-Related Peptide-1
-
FRamide-Related Peptide-1
Question 5
Question
True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.
Answer
- True
- False
Question 6
Question
GnIH is:
Answer
-
Usually released into the portal system, but not in some animals (rats, mice).
-
Released into the portal system, but only in some animals (rats, mice).
Question 7
Question
A major similarity between organisms is that GnIH is always localised in the:
Answer
-
Dorsomedial nucleus of the hypothalamus
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Dorsomedial nucleus of the hippocampus
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Dorsal horn of the hypothalamus
-
Dorsal horn of the hippocampus
Question 8
Question
True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.
Answer
- True
- False
Question 9
Question
True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.
Answer
- True
- False
Question 10
Question
Advantages of using LAB AND DOMESTICATED animals as models include:
(select all that apply)
Answer
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Well-adapted to labs
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Detailed knowledge of genetic background
-
Transgenic manipulation allows specific focus
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Short generation time (longitudinal studies simple and comprehensive)
Question 11
Question
An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?
Answer
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PTSD
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Alzheimer’s
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Cystic Fibrosis
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Developmental disorders
Question 12
Question
Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas:
(select all that apply)
Answer
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Cortical
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Hippocampal
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Hypothalamic
Question 13
Question
The two main histopathological hallmarks of Alzheimer’s Disease (AD) are:
(select the two that apply)
Answer
-
Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases
-
Intracellular Neurofibrillary Tangles (NFTs)
Question 14
Question
True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.
Answer
- True
- False
Question 15
Question
Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons)
(select all that apply)
Answer
-
Wolverines
-
Dolphins
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Polar Bears
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Tasmanian Tigers
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Tasmanian Devils
Question 16
Question
The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:
Answer
-
Degu (Octodon degus)
-
Guinea pig (Cavia porcellus)
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Naked mole-rat (Heterocephalus glaber)
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Domestic dog (Canis familiaris)
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Fat-tailed dunnart (Sminthopsis crassicaudata)
Question 17
Question
What age do Degus start presenting Alzheimer’s symptoms?
Answer
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~3-4 years
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~4-5 years
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~5-6 years
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~6-7 years
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