PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

[blank_start]__________[blank_end] serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the [blank_start]__________[blank_end] triggers release of PTH.

In response to decreased serum Calcium, PTH is released and goes to which of the following?

In the kidney, what PTH has 3 effects. These are: a: [blank_start]_____[blank_end] 1,25 (OH)2 D; b: [blank_start]_____[blank_end] Ca reabsorption; c: [blank_start]_____[blank_end] PO4 reabsorption;

In the bone, PTH has 2 effects. These are: a: ↑ [blank_start]__________[blank_end]; b: ↑ Bone [blank_start]__________[blank_end] (releasing Ca).

PTH-1 is a class-B GPCR. Yeah?

The primary effect of Hyperparathyroidism is:

PROLONGED increase of PTH results in which of the following:

The main effect of INTERMITTENT PTH is:

True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.

Sclerostin is a [blank_start]__________[blank_end] regulator of bone formation.

Mutations that inactivate Sclerostin cause [blank_start]__________[blank_end] bone mass.

Sclerostin is produced by which of the following:

Intermittent PTH [blank_start]__________[blank_end] sclerostin. Sclerostin [blank_start]__________[blank_end] Wnt signaling. Therefore Intermittent PTH has a [blank_start]__________[blank_end] effect on Wnt signalling and results in [blank_start]__________[blank_end] bone formation (and [blank_start]__________[blank_end] bone resorption).