20408532
Descrição
Quiz por Med Student , atualizado more than 1 year ago
|
|
Criado por Med Student
aproximadamente 5 anos atrás
|
|
Questão 1
Questão
Placebo is
Responda
-
allergic drug reaction
-
drug form, without active substance
-
method for treatment of acute pain
-
drug tolerance
Questão 2
Questão
Tobacco smoking
Responda
-
increases drugs metabolism
-
decreases drug metabolism
-
decreases plasma concentrations of methylxanthines
-
doesn’ t change drugs metabolism
Questão 3
Questão
Nocebo effect is
Responda
-
Allergic drug reaction
-
Analgesic method
-
Adverse drug reaction, caused by placebo
-
CNS depression
Questão 4
Questão
When patient and doctor are aware of the contents of the formulation, the trial is defined as
Responda
-
open trial
-
blind trial
-
placebo trial
-
double-blind trial
Questão 5
Questão
Surrogates in rational pharmacotherapy are
Responda
-
clinical- laboratory indexes
-
instrumental investigations - ECG; EMG; MRT etc
-
disease improvement
-
decreased mortality rate
Questão 6
Questão
Pharmacodynamic changes in elderly are
Responda
-
increased sensitivity to drugs suppressing central nervous system
-
decreased sensitivity to drugs suppressing central nervous system
-
paradoxal reactions are observed
-
adverse drug reactions are more frequent
Questão 7
Questão
Steady-state plasma concentration is
Responda
-
blood concentration of the drug 2 hours after administration
-
blood concentration of the drug after repeated administration when there is a balance between absorption and excretion
-
blood concentration of the drug after it has been ceased
-
blood concentration of the drug during its absorption
Questão 8
Questão
Drugs half-life is an index for
Responda
-
the route of administration of the drug
-
the duration of the drug effect when there is a relationship between it and plasma concentrations
-
time to reach steady-state plasma concentration after repeated administration
-
determination of dose interval
Questão 9
Questão
Drugs contraindicated in the first half of pregnancy are
Responda
-
Erythromycin
-
Sex steroids
-
Penicillins
-
Oral anticoagulants
Questão 10
Questão
For pharmacokinetics in elderly is true
Responda
-
decreased excretion
-
decreased metabolism
-
decreased volume of distribution
-
increased volume of distribution
Questão 11
Questão
Reasons for inadequate pharmaceutical availability are
Responda
-
chronic renal failure
-
improper use of the drug formulation
-
bad quality of the drug substance
-
participating in treatment
Questão 12
Questão
Categories of ADRs are
Responda
-
certain
-
probable
-
possible
-
unlikely
Questão 13
Questão
Therapeutic drug monitoring is
Responda
-
method for neuroleptanalgesy
-
used when there is relationship between plasma concentrations and drug effect
-
used for drugs with narrow therapeutic window
-
used for drugs with long half- live
Questão 14
Questão
Irrational ready-made drug formulations contain
Responda
-
drugs with different half-life
-
drugs for ethiotropic and symptomatic treatment
-
drugs with narrow therapeutic window
-
drugs affecting different pathogenic mechanisms
Questão 15
Questão
First phase of clinical trial can be determinated as
Responda
-
first application of a new substance to healthy volunteers
-
first application of a new substance to patients
-
efficacy and safety in a large number of patients
-
post-marketing surveillance in thousands of patients
Questão 16
Questão
Binding of drugs with plasma proteins is important for
Responda
-
half- life
-
drugs interactions
-
bioavailabillity
-
the value of the pharmacological effect
Questão 17
Questão
Adverse drug reactions lead to
Responda
-
increased pharmacological effect
-
decreased risk of toxicity
-
decreased efficacy of the treatment
-
developement of unpredictable drug effects
Questão 18
Questão
Bad compliance of the patient may be due to
Responda
-
dose regimen with many drugs with frequent administration
-
a large number of drugs
-
lack of information for the treatment
-
the drug must be taken once daily
Questão 19
Questão
Fourth phase of clinical trial can be determinated as
Responda
-
first application of a new substance to healthy volunteers
-
first application of a new substance to patients
-
efficacy and safety in a large number of patients
-
post-marketing surveillance in thousands of patients
Questão 20
Questão
Drugs clearance is
Responda
-
Amount of drug, that reaches systemic circulation
-
Blood plasma volume from which the drug is eliminated for defined period of time
-
Steady- state plasma concentration
-
Withdrawal syndrome
Questão 21
Questão
Monitoring of therapeutic plasma concentrations is necessary for
Responda
-
theophyllin
-
phenobarbital
-
carbamazepin
-
amoxicillin
Questão 22
Questão
Third phase of clinical trial can be determinated as
Responda
-
first application of a new substance to healthy volunteers
-
first application of a new substance to patients
-
efficacy and safety in a large number of patients
-
post-marketing surveillance in thousands of patients
Questão 23
Questão
Clearance is an index for
Responda
-
drugs excretion
-
determination of mantaining dose of the drugs
-
drugs absorbtion
-
effects of the drugs on the heart
Questão 24
Questão
Pharmacogenetic differences lead to
Responda
-
decreased effect
-
increased effect
-
development of adverse drug reactions
-
avitaminosis
Questão 25
Questão
Drug surveillance is done by
Responda
-
spontaneous reporting
-
observation studies
-
family doctors
-
population statistics
Questão 26
Questão
Adverse drug reactions are the following types
Responda
-
augmented
-
bizarre
-
chronic
-
delayed
Questão 27
Questão
Mechanisms of drug interactions are
Responda
-
unpredictable
-
pharmacokinetic
-
pharmacodynamic
-
pharmaceutical
Questão 28
Questão
The quality of therapeutic decision (outcomes) can be measured by
Responda
-
clinical outcomes
-
costs — direct and indirect
-
functional status pf patient
-
overall patient satisfaction
Questão 29
Questão
Method of evaluation of cost/benefits ration are
Responda
-
cost minimization analysis
-
cost effectiveness analysis
-
cost utility analysis
-
cost consequence analysis
Questão 30
Questão
Drug metabolism involving some enzyme defects includes the following reactions
Responda
-
acetylation
-
oxidation
-
hydrolysis
-
red cells enzyme defects
Questão 31
Questão
The reasons for drug abuse are
Responda
-
relief of anxiety, tension and depression
-
entertainment, fun
-
improvement of performance in competitive sports
-
conformity with own social subgroup
Questão 32
Questão
How many types of dependence do you know?
Responda
-
psychological
-
physical (physiological)
-
acute
-
chronic
Questão 33
Questão
Which pharmacological drug groups cause drug dependence and tolerance?
Responda
-
Opioid analgesics
-
Antidepressants
-
CNS stimulants
-
Benzodiazepines
Questão 34
Questão
The neuropharmacological mechanisms of drug addiction are
Responda
-
activation of endogenous opiate encephalin receptors
-
activation of μ-opioid receptors in the brain
-
activation of cannabinoid receptors (CB1) in the hypothalamus
-
increase of glutamate release in the brain cortex
Questão 35
Questão
Benzodiazepine withdrawal syndrome is characterized by
Responda
-
it develops after 6-weeks of treatment
-
it develops after 2 weeks of treatment
-
psychological symptoms — anxiety, agitation, insomnia, seizures
-
physical symptoms — nausea, vomiting, muscle pain, ataxia
Questão 36
Questão
Opioid (heroin, morphine) withdrawal syndrome is characterized by
Responda
-
begins 8 hours after last dose
-
the peak is between 36-72 h
-
first physical symptoms are lacrimation, rhinorrhea and sweating
-
abdominal cramps, diarrhoea, bone and muscle pain, weakness and chills
Questão 37
Questão
Why is methadone used for treatment of opioid-dependence?
Responda
-
it is taken orally
-
it is applied intravenously
-
has prolonged action
-
has short-action
Quer criar seus próprios Quizzes gratuitos com a GoConqr? Saiba mais.