412616
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
aproximadamente 11 anos atrás
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Questão 1
Questão
What is the role of the Rb Susceptibility gene?
Responda
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Nuclear transcription factor
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Nuclear phosphatases
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Nuclear phosphorylases
Questão 2
Questão
What protein does Rb bind to?
Responda
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E2F
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FF2
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EF2
Questão 3
Questão
What is the role of the protein bound to Rb?
Responda
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Transcription factor
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Kinase
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Phosphatase
Questão 4
Questão
What are the target genes of the Rb bound protein?
Responda
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dNTP producing genes
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Transcription factor producing genes
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Growth factor producing genes
Questão 5
Questão
How is Rb phosphorylated and deactivated?
Responda
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By Cyclin
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By CDK
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By a cyclin/CDK dimer
Questão 6
Questão
What protein phosphorylates CDK?
Responda
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CAK
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CAD
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CAB
Questão 7
Questão
Which forms first during G1?
Responda
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CDK/Cyclin D
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CDK/Cyclin E
Questão 8
Questão
What causes the production of Cyclin/CDK E &D?
Responda
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Jun Activity
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AP1 Activity
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Myc Activity
Questão 9
Questão
Which is required to activate E2F?
Responda
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Cyclin/CDK D
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Cyclin/CDK E
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Both
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Neither
Questão 10
Questão
Name 3 CDK inhibitors
Responda
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p13
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p21
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p12
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p16
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p27
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p19
Questão 11
Questão
Which of the following binds to CDK, & twists its head to block the active site?
Responda
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p16
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p12
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p19
Questão 12
Questão
Which of the following bind to cdk with cyclin and physically block the active site?
Responda
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p21
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p27
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p19
Questão 13
Questão
How are the CDK inhibitors controlled?
Responda
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Phosphorylation & degredation
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Phosphorylation & activation
Questão 14
Questão
How long is the bp sequence p53 binds to?
Responda
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10 bp
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12 bp
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15 bp
Questão 15
Questão
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Responda
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D-A-E-C-B
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D-A-C-E-B
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A-D-C-E-B
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B-A-D-E-C
Questão 16
Questão
How does p53 work in its active form?
Responda
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As a monomer
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As a dimer
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As a tetramer
Questão 17
Questão
What does p53 bind to when active?
Responda
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TATA boxes
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E-boxes
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Damaged DNA
Questão 18
Questão
What can cause the activation of p53?
Responda
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Acetylation
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Phosphorylation
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Ionising radiation
Questão 19
Questão
What does p53 do if activated in G1?
Responda
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Repairs DNA
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Reverts the cell back to G0
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Forces cell through mitotic cycle
Questão 20
Questão
What happens if p53 is activated after G1?
Responda
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Bax is transcribed- it initiates apoptosis
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Bax is transcribed- It initiates S phase
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Bax is transcribed- It inhibits M phase
Questão 21
Questão
Where do mutations causing non-function tend to occur in p53?
Responda
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The DNA binding domain
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The damaged DNA binding domain
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The signalling domain
Questão 22
Questão
How is p53 removed from the cell?
Responda
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MDM2
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MDM
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MDM1
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