412616
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
|
Criado por gina_evans0312
quase 11 anos atrás
|
|
Questão 1
Questão
What is the role of the Rb Susceptibility gene?
Responda
-
Nuclear transcription factor
-
Nuclear phosphatases
-
Nuclear phosphorylases
Questão 2
Questão
What protein does Rb bind to?
Responda
-
E2F
-
FF2
-
EF2
Questão 3
Questão
What is the role of the protein bound to Rb?
Responda
-
Transcription factor
-
Kinase
-
Phosphatase
Questão 4
Questão
What are the target genes of the Rb bound protein?
Responda
-
dNTP producing genes
-
Transcription factor producing genes
-
Growth factor producing genes
Questão 5
Questão
How is Rb phosphorylated and deactivated?
Responda
-
By Cyclin
-
By CDK
-
By a cyclin/CDK dimer
Questão 6
Questão
What protein phosphorylates CDK?
Responda
-
CAK
-
CAD
-
CAB
Questão 7
Questão
Which forms first during G1?
Responda
-
CDK/Cyclin D
-
CDK/Cyclin E
Questão 8
Questão
What causes the production of Cyclin/CDK E &D?
Responda
-
Jun Activity
-
AP1 Activity
-
Myc Activity
Questão 9
Questão
Which is required to activate E2F?
Responda
-
Cyclin/CDK D
-
Cyclin/CDK E
-
Both
-
Neither
Questão 10
Questão
Name 3 CDK inhibitors
Responda
-
p13
-
p21
-
p12
-
p16
-
p27
-
p19
Questão 11
Questão
Which of the following binds to CDK, & twists its head to block the active site?
Responda
-
p16
-
p12
-
p19
Questão 12
Questão
Which of the following bind to cdk with cyclin and physically block the active site?
Responda
-
p21
-
p27
-
p19
Questão 13
Questão
How are the CDK inhibitors controlled?
Responda
-
Phosphorylation & degredation
-
Phosphorylation & activation
Questão 14
Questão
How long is the bp sequence p53 binds to?
Responda
-
10 bp
-
12 bp
-
15 bp
Questão 15
Questão
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Responda
-
D-A-E-C-B
-
D-A-C-E-B
-
A-D-C-E-B
-
B-A-D-E-C
Questão 16
Questão
How does p53 work in its active form?
Responda
-
As a monomer
-
As a dimer
-
As a tetramer
Questão 17
Questão
What does p53 bind to when active?
Responda
-
TATA boxes
-
E-boxes
-
Damaged DNA
Questão 18
Questão
What can cause the activation of p53?
Responda
-
Acetylation
-
Phosphorylation
-
Ionising radiation
Questão 19
Questão
What does p53 do if activated in G1?
Responda
-
Repairs DNA
-
Reverts the cell back to G0
-
Forces cell through mitotic cycle
Questão 20
Questão
What happens if p53 is activated after G1?
Responda
-
Bax is transcribed- it initiates apoptosis
-
Bax is transcribed- It initiates S phase
-
Bax is transcribed- It inhibits M phase
Questão 21
Questão
Where do mutations causing non-function tend to occur in p53?
Responda
-
The DNA binding domain
-
The damaged DNA binding domain
-
The signalling domain
Questão 22
Questão
How is p53 removed from the cell?
Responda
-
MDM2
-
MDM
-
MDM1
Quer criar seus próprios Quizzes gratuitos com a GoConqr? Saiba mais.