PHSI3011 13-1 Circadian Rhythm and Disease

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PHSI3011 13-1 Circadian Rhythm and Disease
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine about 7 years ago
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Resource summary

Question 1

Question
The SCN is [primarily?] responsible for heaps of the Circadian Rhythm stuff. What is it?
Answer
  • Sagittal Central Nucleus
  • SupraCentral Nucleus
  • Sagittal Cortical Nucleus
  • SupraCortical Nucleus
  • SupraChiasmal Nucleus
  • Sagittal Chiasmal Nucleus

Question 2

Question
The CLOCK and BMAL1 genes are downregulated through negative feedback from which of the following?
Answer
  • PER
  • CRY
  • RORa
  • CCGs

Question 3

Question
Deepest sleep [normally] occurs at what time?
Answer
  • 12am
  • 1am
  • 2am
  • 3am
  • 4am
  • 4:30am
  • 6am
  • 6:30am

Question 4

Question
Jet lag results in a desynchrony between the sleep-wake cycle and the Melatonin rhythm on:
Answer
  • Blood transcriptome
  • Plasma transcriptome
  • Renal transcriptome
  • Mitochondrial transcriptome

Question 5

Question
Human circadian rhythm disorders that maintain a stable entrainment in relation to the 24-hour day-night cycle include:
Answer
  • Delayed Sleep Phase Disorder (DSPD)
  • Advanced Sleep Phase Disorder (ASPD)
  • Non-24-Hour Sleep-Wake Syndrome
  • Irregular Sleep-Wake Rhythm (ISWR)
  • Shift Work Sleep Syndrome
  • Time Zone Change Syndrome
  • Free-Running Disorder (FRD)

Question 6

Question
Free-Running Disorder (FRD) is:
Answer
  • A progressive pattern of 1- to 2- hour delays in sleep onset and wake times
  • Temporally disorganised and variable episodes of sleeping and waking behaviour with short sleep periods of a few hours that are distributed randomly through the day and night
  • Somnambulism
  • Sleepwalking

Question 7

Question
The endogenous cycle is how many hours?
Answer
  • 23
  • 24
  • 25

Question 8

Question
Mutations in CLOCK or PER3 can result in Delayed Sleep Phase Disorder (DSPD). This has been associated with metabolic & psychiatric disorders (e.g. depression, schizophrenia), but is also associated with which of the following:
Answer
  • Extreme eveningness preference
  • Extreme morningness preference

Question 9

Question
Treatments of human circadian rhythm disorders include:
Answer
  • Timed melatonin administration
  • Phase resetting – bright light administration
  • Melatonin agonists
  • Toughening the fuck up

Question 10

Question
Disruption of circadian rhythms can lead to:
Answer
  • Metabolic Imbalance
  • Disruption in melatonin levels
  • Disruption in blood glucose levels
  • Insulin resistance
  • Crankiness

Question 11

Question
True or false: Circadian rhythm disruptions have been linked to cancer.
Answer
  • True
  • False
  • ...true AND false.
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