The SCN is [primarily?] responsible for heaps of the Circadian Rhythm stuff. What is it?
Answer
Sagittal Central Nucleus
SupraCentral Nucleus
Sagittal Cortical Nucleus
SupraCortical Nucleus
SupraChiasmal Nucleus
Sagittal Chiasmal Nucleus
Question 2
Question
The CLOCK and BMAL1 genes are downregulated through negative feedback from which of the following?
Answer
PER
CRY
RORa
CCGs
Question 3
Question
Deepest sleep [normally] occurs at what time?
Answer
12am
1am
2am
3am
4am
4:30am
6am
6:30am
Question 4
Question
Jet lag results in a desynchrony between the sleep-wake cycle and the Melatonin rhythm on:
Answer
Blood transcriptome
Plasma transcriptome
Renal transcriptome
Mitochondrial transcriptome
Question 5
Question
Human circadian rhythm disorders that maintain a stable entrainment in relation to the 24-hour day-night cycle include:
Answer
Delayed Sleep Phase Disorder (DSPD)
Advanced Sleep Phase Disorder (ASPD)
Non-24-Hour Sleep-Wake Syndrome
Irregular Sleep-Wake Rhythm (ISWR)
Shift Work Sleep Syndrome
Time Zone Change Syndrome
Free-Running Disorder (FRD)
Question 6
Question
Free-Running Disorder (FRD) is:
Answer
A progressive pattern of 1- to 2- hour delays in sleep onset and wake times
Temporally disorganised and variable episodes of sleeping and waking behaviour with short sleep periods of a few hours that are distributed randomly through the day and night
Somnambulism
Sleepwalking
Question 7
Question
The endogenous cycle is how many hours?
Answer
23
24
25
Question 8
Question
Mutations in CLOCK or PER3 can result in Delayed Sleep Phase Disorder (DSPD). This has been associated with metabolic & psychiatric disorders (e.g. depression, schizophrenia), but is also associated with which of the following:
Answer
Extreme eveningness preference
Extreme morningness preference
Question 9
Question
Treatments of human circadian rhythm disorders include:
Answer
Timed melatonin administration
Phase resetting – bright light administration
Melatonin agonists
Toughening the fuck up
Question 10
Question
Disruption of circadian rhythms can lead to:
Answer
Metabolic Imbalance
Disruption in melatonin levels
Disruption in blood glucose levels
Insulin resistance
Crankiness
Question 11
Question
True or false: Circadian rhythm disruptions have been linked to cancer.