50121
ACUTE INFLAMMATION 2/2
- CHEMOTAXSIS: chemical attraction
- Arrival of neutrophils is mediated by CHEMOTACTIC FACTORS
- These factors bind to receptors on tissue damage and activate messenger signals
- Main chemotactic factors: COMPLOMENT(C5a), LEUKOTRIENE(LTB4), BACTERIAL TOXINS
- Main chemotactic factors: COMPLOMENT(C5a), LEUKOTRIENE(LTB4), BACTERIAL TOXINS
- These factors bind to receptors on tissue damage and activate messenger signals
- Arrival of neutrophils is mediated by CHEMOTACTIC FACTORS
- ROLE OF NEUTROPHILS
- MOTILITY
- ADHESION TO MICROORGANISMS
- PHAGOCYTOSIS
- INTRACELLULAR KILLING
- RELEASE OF LYSOSOMAL PRODUCTS
- RELEASE OF LYSOSOMAL PRODUCTS
- INTRACELLULAR KILLING
- PHAGOCYTOSIS
- ADHESION TO MICROORGANISMS
- MOTILITY
- OPSONIN: A binding enhancer for pahgocytosis
- PHAGOCYTOSIS
- Polymorphonuclear Leukocytes attachby membrane receptors
- Surround it by pseudopodia, which fuse together
- Lysosomes fuse(digestive enzymes)
- after destroyed clearing up is left to macrophages
- after destroyed clearing up is left to macrophages
- Lysosomes fuse(digestive enzymes)
- Surround it by pseudopodia, which fuse together
- Polymorphonuclear Leukocytes attachby membrane receptors
- The main purpose of inflammation is to protect tissues: chance of damage still exists
- KININS:PROTEINS FROM BLOOD
- Activated by coagulation factorXII (Hageman factor)
- Most important in bradykinin - pain mediator
- Most important in bradykinin - pain mediator
- Activated by coagulation factorXII (Hageman factor)
- INFLAMMATORY MEDIATORS
- Cause:VASODILATION
- EMIGRATION OF NEUTROPHILS
- CHEMOTAXIS AND INCREASED VASCULAR PERMEABILITY
- CHEMOTAXIS AND INCREASED VASCULAR PERMEABILITY
- EMIGRATION OF NEUTROPHILS
- CELLULAR MAEDIATORS:
- HISTAMINE
- LYSOSOMAL COMPOUNDS
- LEUKOTRIENES
- LEUKOTRIENES
- PROSTAGLANDINS
- SERETONIN
- LYMPHOKINES
- SERETONIN
- HISTAMINE
- Cause:VASODILATION
- COMPLEMENT
- Enzymatic proteins produced in the liver and secreted into blood
- Helps Ab and phagocytic cells to clear pathogens
- OPSONISATION:enhances phagocytosis, IgG and c3
- CHEMOTAXSIS:attraction of other immune cells
- LYSIS: rupturing foreign cells
- CLUMPING:of antigens
- CLUMPING:of antigens
- LYSIS: rupturing foreign cells
- CHEMOTAXSIS:attraction of other immune cells
- OPSONISATION:enhances phagocytosis, IgG and c3
- Helps Ab and phagocytic cells to clear pathogens
- Enzymatic proteins produced in the liver and secreted into blood
- COAGULATION SYSTEM
- Conversion of FIBRINOGEN to FIBRIN
- Major component of inflammatory exudate
- Major component of inflammatory exudate
- Conversion of FIBRINOGEN to FIBRIN
- POSSIBLE OUTCOMES OF AI
- RESOLUTION:minimal cell death, rapid destruction of agent, removal of exudate
- SUPPURATION:formation of pus, agent is persistent, surrounded by pyogenic membrane
- ORGANISATION:replacement of tissue with granular tissue
- ORGANISATION:replacement of tissue with granular tissue
- SUPPURATION:formation of pus, agent is persistent, surrounded by pyogenic membrane
- RESOLUTION:minimal cell death, rapid destruction of agent, removal of exudate
- PROGRESSION TO CHRONIC
- If causative agent persists - character of exudate changes lymph and macrophages
- If causative agent persists - character of exudate changes lymph and macrophages
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