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380929
RTKs
Description
cell signalling Mind Map on RTKs, created by fatimaelfitouri on 22/11/2013.
No tags specified
cell signalling
cell signalling
Mind Map by
fatimaelfitouri
, updated more than 1 year ago
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Created by
fatimaelfitouri
over 10 years ago
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Resource summary
RTKs
Receptor tyrosine kinase (RTK)
PDGFR
insulin R
more than 50 identified
single polypeptides except insulin R
structure
transmembrane
variety of extracellular domain
Enter text here
ligand binding domain in the extracellular region
a single transmembrane helix
cytoplasmic region containing a protein tyrosine kinase (TK) domian, carboxyl terminal and juxtamembrane regulatory region
induction
ligand binds to receptor= dimerisation of receptor
dimerisation promotes autophosphorylation
some RTKs form oligmers in the absence of activating ligands eg insulin R and IGF1R
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