PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone

Beschreibung

PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone
Michael Jardine
Quiz von Michael Jardine, aktualisiert more than 1 year ago
Michael Jardine
Erstellt von Michael Jardine vor fast 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Autocrine vs paracrine vs endocrine signalling: Autocrine = Acts on [blank_start]__________[blank_end]; Endocrine = Acts on [blank_start]__________[blank_end]; Paracrine = Acts on[blank_start]__________[blank_end];
Antworten
  • Itself
  • Distant tissue
  • Nearby tissue
  • External organisms

Frage 2

Frage
Fill in the gaps
Antworten
  • RANKL
  • RANK
  • OPG
  • CSF-1
  • Calcitonin
  • PTH

Frage 3

Frage
What does OPG do to RANKL?
Antworten
  • Fuck all
  • Inhibits ligand-binding
  • Facilitates ligand-binding

Frage 4

Frage
What effect does Calcitonin have on Osteoblasts?
Antworten
  • Inhibits Osteoblast activity
  • Fuck all
  • Ensures their precursor's survival

Frage 5

Frage
What effect does Calcitonin have on Osteoclasts?
Antworten
  • Inhibits Osteoclast activity
  • Fuck all
  • Ensures their precursor's survival

Frage 6

Frage
What effect does CSF1 have on Osteoblasts?
Antworten
  • Inhibits Osteoblast activity
  • Fuck all
  • Ensures precursor's survival

Frage 7

Frage
What effect does CSF1 have on Osteoclasts?
Antworten
  • Inhibits Osteoclast activity
  • Fuck all
  • Ensures precursor's survival

Frage 8

Frage
OCN is a hormone involved in the regulation of glucose metabolism, which improves the sensitivity of target organs to insulin, thus improving glucose handling by the body. …and MAYBE stimulates insulin production/secretion. Still, OCN = ??
Antworten
  • OsteoCalciN
  • OsteoCalcitoniN

Frage 9

Frage
OCN is the most abundant [blank_start]__________[blank_end] in bone.
Antworten
  • Non-collagenous protein
  • Mineral
  • Collagenous protein
  • Neurotransmitter
  • Osteokine

Frage 10

Frage
ADHR = ??
Antworten
  • Autosomal Dominant Hypophosphataemic Rickets
  • Adrenal Dominant Hypophosphataemic Rickets
  • Autosomal Dominant Hyperphosphataemic Rickets
  • Adrenal Dominant Hyperphosphataemic Rickets

Frage 11

Frage
OOM = ??
Antworten
  • Oncogenic OsteoMalacia
  • Osteogenic OncoMalacia

Frage 12

Frage
ADHR and OOM are examples of what?
Antworten
  • Phosphate-wasting disorders
  • Calcium-wasting disorders
  • Vitamin-D-wasting disorders
  • Vitamin-K-wasting disorders

Frage 13

Frage
Mis-sense mutations in [blank_start]__________[blank_end] in ADHR patients at a furin consensus cleavage site results in a resistance to proteolysis.
Antworten
  • FGF23
  • Interleukin 6
  • Interleukin 15
  • FGF6

Frage 14

Frage
FGF23 regulates [blank_start]__________[blank_end] concentrations in plasma. It’s secreted by osteocytes in response to low [above] or [blank_start]__________[blank_end] Vitamin D.
Antworten
  • Phosphate
  • OPG
  • OCN
  • Calcium
  • Vitamin D
  • High
  • Low

Frage 15

Frage
FGF23 acts on the kidneys, where it [blank_start]__________[blank_end] the expression of NPT2 (a Na-PO4 co-transporter in the proximal tubule). This leads to [blank_start]__________[blank_end] PO4 reabsorption (which results in [blank_start]__________[blank_end] excretion).
Antworten
  • Decreases
  • Increases
  • Increased
  • Decreased
  • Increased
  • Decreased
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