PHSI3012 11-1 Pathogenesis of Obesity (T3L3)

In 2011, 62.8% of Australians over 18yo were __________.

Which of the following can go along with obesity?

The average energy expenditure is roughly [blank_start]__________[blank_end] kcal/day.

Does Ghrelin stimulate or suppress hunger/feeding?

Does Peptide YY (PYY) induce hunger or satiety?

Leptin downregulates the production of appetite-[blank_start]__________[blank_end] neuropeptides.

Does Insulin push you towards hunger or satiety?

Environmental- vs Genetic- determinants of obesity. [blank_start]__________[blank_end] accounts for ~30-40%; [blank_start]__________[blank_end] accounts for ~60-70%.

Adoption studies suggest a stronger role for [blank_start]__________[blank_end] than [blank_start]__________[blank_end] in predicting future weight.

Which of the following two single-gene-defects could cause Rapid weight gain, Hyperplasia?

Which of the following is the most common single-gene cause of obesity? (it’s only present in 2-5% of persons with severe obesity, though!)

There are shitloads of genes associated with obesity. Broadly 4 categories (Monogenic oligogenic; Fat distribution-related; BMI-related genes; Overweight, Obesity-related). Treating them as a Venn diagram, what’s the only one in the overlap of all 4?

Gastric banding results in a mean weight reduction of [blank_start]__________[blank_end] at 1 year.

Vertical-sleeve Gastrectomy results in what mean % weight reduction at 1 year?

Roux-en-Y Gastric Bypass (RNY) results in what mean % weight reduction at 1 year?